Search PubMed⌕ Search

Biomedical subjects

E Dupont

Publications and source records attributed to E Dupont.

At least 217 records · Page 12Linked to original sources
PubMed1983

The effect of the GABA-agonist, progabide, on benign essential tremor. A controlled clinical trial.

In a double-blind crossover trial of two 2-week treatment periods, to which 18 patients with benign essential tremor were admitted, there was no statistically significant different between progabide 11.4-20.2 mg/kg X day (median 14.2 mg/kg X day) and placebo in tremor score and tremor amplitude. However, there was a definite placebo and period effect with reduction of tremor score and tremor amplitude during the second period of treatment compared to the first period of treatment, regardless of the treatment regime. This was presumably a result of prolonged treatment and habituation to the test situation and not an effect of the active drug. No side-effects were registered and no laboratory abnormalities were seen.

Adult↗
PubMed1983

Depletion of lymphocytes with membrane markers of helper phenotype: a feature of acute and chronic drug-induced immunosuppression.

T cell subsets tested with markers for Fc receptors for Ig (TM, TG and EAhu rosettes) or monoclonal antibodies (T4 and T8 lymphocytes) were investigated both in normal volunteers and in kidney transplant recipients with a well functioning graft and receiving low immunosuppressive therapy, before and 4 hr after administration of 100 mg of hydrocortisone. Hydrocortisone induced a redistribution which was characterized by a decrease in the percentages of TM (38 +/- 2.4 before; 22 +/- 2.9 after; P less than 0.0005) and T4 (48 +/- 2.6 before; 35.8 +/- 2.7 after; P less than 0.0025) lymphocytes. Transplanted patients under chronic immunosuppression already disclosed a reduction of the percentages of TM (19.4 +/- 2.6; P less than 0.005) and T4 (41.1 +/- 3.6; P less than 0.05) lymphocytes before the administration of hydrocortisone when compared to the values obtained in normals. Moreover, significant decrease of percentages of TM lymphocytes (19.4 +/- 2.6 before; 12.8 +/- 2.6 after; P less than 0.01) were obtained after hydrocortisone injection. In contrast, T8, TG and EAhu rosettes percentages were characterized by a relative resistance to immunosuppressive agents--the only exception being TG lymphocytes in transplant recipients. It is concluded that TM and T4 depletion is a common feature of acute and chronic drug-induced immunosuppression, suggesting that helper-inducer cells are important targets for immunosuppressive therapy.

Adult↗
PubMed1983

Haemodialysis, continuous ambulatory peritoneal dialysis and cellular immunity.

The cellular immunity of haemodialysis and continuous ambulatory peritoneal dialysis (CAPD) patients was studied with regards to T-lymphocyte subsets and to suppressor T-cell function. The two groups of patients showed similar alterations: low proportions of suppressor-cytotoxic T-cells and low suppressive activity. In both groups there is a deterioration of this suppressive activity with time on dialysis.

Aged↗
PubMed1983

[Factors influencing the survival of the patient and the graft in kidney transplants].

The influence of several prognostic factors in kidney transplantation was studied by the actuarial method from the data collected on 332 grafts performed at one center from 1971 to 1982. Taking into account the various interactions between these factors, 3 survival parameters were calculated: patient's survival, immunologic tolerance of the graft and overall graft survival. The relevant prognostic factors, ranked in decreasing order, are: origin of the graft, immunosuppressive therapy, recipient's age, recipient's HBs status and number of blood transfusions administered prior to transplantation, HLA presensitization and HLA-A,B matching. Integration of these factors leads to a precise estimation of the risk of transplantation from the characteristics of the graft and those of the potential recipients, thereby allowing to select the best candidate.

Adult↗
PubMed1982

Low cerebrospinal fluid somatostatin in Parkinson disease: an irreversible abnormality.

In 39 parkinsonian patients, CSF somatostatin content was 88.0 +/- 4.1 pg per milliliter, which was about 40% less than in controls (147.3 +/- 5.1 pg per milliliter). Somatostatin values were unrelated to age, sex, body weight, total CSF protein, immunoglobulin, or cell count in either group. Parkinsonian values were not related to duration of disease, severity, specific signs, or treatment. In contrast to multiple sclerosis, in which CSF somatostatin is low only during relapses, the low somatostatin content of CSF in Parkinson disease seems to be irreversible, to be present at the onset of symptoms, and to imply an irreparable functional or structural alteration of somatostatin-secreting neurons.

Adult↗
PubMed1982

[Transplantation of pediatric kidneys into adult patients (author's transl)].

Fourteen adult patients were transplanted with a single pediatric kidney and were followed for 26 days to 9 years. Donor ages ranged from 22 months to 10 years, recipient ages from 15 to 47 years. Ten transplants functioned for more than one year. Three kidneys were rejected after 26 days, 3 months and 18 months. Three patients died 2, 6 and 13 months after transplantation from aspergillosis, cytomegalovirus infection and salmonellosis. Eight kidney grafts are currently functioning 2 to 9 years after transplantation. Serum creatinin levels range between 0.9 and 1.1 mg/dl in 7 patients. One woman with chronic rejection has a serum creatinin level of 2.5 mg/dl. A single pediatric kidney is able to sustain a satisfactory renal function in an adult recipient.

Adult↗
PubMed1981

[Dietary milks].

Explore the source record for details and available documents.

Animals↗
PubMed1981

Nature and frequency of dental changes in idiopathic hypoparathyroidism and pseudohypoparathyroidism.

Eleven patients with idiopathic hypoparathyroidism and pseudohypoparathyroidism were examined orally and medically. All patients had a history of tetanic and/or epileptic manifestations. Correspondingly, disturbances in the metabolism of calcium and phosphorus had been present in all. Dental anomalies were demonstrated in all patients but one. Enamel hypoplasia was observed in six cases, disturbances in tooth eruption in eight, root defects in five and hypodontia in seven. Dental anomalies were more frequent than could be expected from the literature, probably because the dental aspects of hypoparathyroid disease often have been overlooked. In the present material, the above-mentioned disturbances were most severe and frequent in the pseudohypoparathyroid group. Hypoparathyroid conditions are highly invalidating, easily accessible to treatment, but often undiagnosed for years. Therefore, the dental observation of severe disturbances in tooth formation and eruption pattern may be of crucial importance and should lead to further medical investigation.

Adolescent↗