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Biomedical subjects

E Duggan

Publications and source records attributed to E Duggan.

12 recordsLinked to original sources
PubMed1988

Urinary lactic acid dehydrogenase activity and the site of urinary tract infections.

A report that elevated urinary lactic acid dehydrogenase (LDH) isoenzyme 5 activity is a reliable tool for separating patients with upper from those with lower urinary tract infections (UTIs) led us to study urinary LDH enzyme activity in girls having bladder washout studies to localize the site of infection. Urinary LDH isoenzyme 5 activity in 64 instances of lower UTI was 16.1 +/- 3.3%, a value not significantly different than that of 18.2 +/- 12.6% found in 26 instances of upper tract infection (t = 0.8726, P = 0.1928). The data show that LDH isoenzyme 5 activity is of no value for localization of the site of a UTI. The data of these studies also showed that urinary LDH enzyme activity clearly separates girls with UTIs from those without infections, but it is unlikely that this finding will be of value in diagnosis or management.

Adolescent↗
PubMed1987

Vascular trauma.

Civilian vascular trauma is not uncommon. Prompt treatment with modern vascular surgical techniques produces good results.

Blood Vessels↗
PubMed1986

Elevated serum creatinine levels in three patients treated with phenacemide.

Three adolescent patients with severe seizure disorders were treated with phenacemide. All three patients showed elevated serum creatinine and normal blood urea nitrogen values while on phenacemide. Simultaneous urea and creatinine clearance studies performed on each patient demonstrated normal urea clearances and decreased creatinine clearances. Inulin clearance performed in one patient was normal. The medication was discontinued in two of the patients because of co-existing neutropenia. Serum creatinine values returned to normal after phenacemide treatment was terminated. The elevation in serum creatinine values with phenacemide appears to be dose related, reversible, and unrelated to impairment of glomerular filtration.

Adolescent↗
PubMed1985

Wegener granulomatosis in pediatric patients.

Wegener granulomatosis is more easily recognized as a distinct clinical entity than other vasculitides because the initial clinical features frequently include granulomatous vasculitis of the upper and lower respiratory tract and glomerulonephritis. Although the disease has been lethal in the past, prolonged survival and avoidance of end-stage kidney disease can now be expected when cyclophosphamide therapy is introduced early in the course. We report four children with Wegener granulomatosis in whom the initial clinical findings suggested Henoch-Schönlein purpura. In two of the patients Wegener granulomatosis was not recognized until after end-stage kidney disease had developed. The course in these patients emphasizes the need for attention to even scant evidence of inflammation of the upper or lower respiratory tract in patients with glomerulonephritis. Appropriate diagnostic studies may then lead to recognition of Wegener granulomatosis and the prompt institution of appropriate treatment.

Adolescent↗
PubMed1985

Follow-up studies on children with severe dietary chloride deficiency during infancy.

Ten children who had severe dietary chloride deficiency during early infancy have grown normally during their first 4 to 5 years. With the exception of one child who did not get into the sitting position alone until he was 9 1/2 months of age, the patients reached the usual developmental milestones of the first 2 years during the expected age intervals. Developmental and psychological testing indicates that all of the children have at least average ability. However, three children have shown behavior patterns that may interfere with successful school performance. Serum creatinine and urea nitrogen concentrations appear to be normal as does renal concentrating capacity. During a 4-year follow-up, one child has shown persistent and a second intermittent microscopic hematuria.

Alkalosis↗
PubMed1982

Serum C-reactive protein and the site of urinary tract infections.

Elevated surum levels of C-reactive protein have been found regularly in girls with acute clinical pyelonephritis but only infrequently in those with clinical cystitis. Based on these data, the suggestion has been made that elevated serum CRP concentrations may be useful in identifying patients with upper urinary tract infections. In a study in which the bladder washout test was used to localize the site of urinary tract infections, we identified nine girls with renal bacteriuria who did not have clinical findings suggesting acute pyelonephritis; four of these girls had serum CRP concentrations less than 10 micrograms/ml. Twenty-eight girls had bladder washout-proven lower urinary tract infections; three of these had serum CRP values greater than 30 micrograms/ml. These studies show that an elevated serum CRP concentration is not accurate in localizing the site of a urinary tract infection in girls who do not have clinical signs of acute pyelonephritis.

Adolescent↗
PubMed1981

Localization of the site of urinary tract infections with the bladder washout test.

The data from 100 bladder washout studies on pediatric patients have been analyzed to derive criteria for interpretation of this test and to define the limitations of this procedure in localization of the site of urinary tract infections. Using the bladder washout test, infection of the upper urinary tract is characterized by an abrupt increase in the concentration of bacteria in urinary specimens collected following urinary bladder sterilization. Infection limited to the lower urinary tract is characterized by scant if any bacterial growth in the specimens of urine collected following bladder sterilization. The site of infection may be incorrectly localized to the lower urinary tract or classified as not determined in patients with scant or intermittent renal bacteriuria.

Adolescent↗
PubMed1980

The dietary chloride deficiency syndrome.

Chronic depletion of body chloride developed in a group of infants ingesting a diet consisting almost exclusively of chloride deficient Neo-Mull-Soy. Ten of the 12 infants were on this diet three to five months before loss of appetite, failure to thrive, muscle weakness, and lethargy led to a diagnostic evaluation. The outstanding laboratory features were severe hypokalemic metabolic alkalosis, low urinary chloride concentrations (< 10 mEq/liter), and erythrocyturia. There was marked decrease in weight for age in all 12 infants. Head circumference for age had decreased in five of six and length for age in five of ten infants for whom earlier measurements were available. The biochemical abnormalities reverted to normal following dietary supplementation with either sodium or potassium chloride. Appetite, affect, and muscle strength improved, and weight gain resumed. Head circumference for age has moved toward the percentile level present prior to starting Neo-Mull-Soy in all instances. With one exception, length measurements show a similar pattern. The erythrocyturia has decreased or vanished. Chloride deficiency led to contraction of the extracellular volume and the substitution of poorly reabsorbable anions for readily reabsorbable chloride. These alterations caused development of the negative hydrogen ion and potassium balances which led to the hypokalemic metabolic alkalosis.

Alkalosis↗
PubMed1974

Sexual and other abnormalities in the family of a transsexual.

A case of transsexualism with homosexuality of Kinsey type 6 is described, in whose maternal kinship were found a large number of persons with various types of sexual abnormalities including one case of probable transsexualism. The pattern of intermarriage produces from generation to generation an increasing number of children with such abnormalities. The patient and a number of relatives also show epilepsy. That disorder seems to exist mainly in the paternal kinship, and the coexistence of transexxualism and epilepsy in the patient seems coincidental.

Adolescent↗