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Biomedical subjects

E Dreher

Publications and source records attributed to E Dreher.

At least 73 records · Page 4Linked to original sources

[Ultrasonic diagnosis of ovarian carcinoma].

Gray-scale ultrasonography was performed prior to surgery in 68 patients with tumors of the ovary. Thirty-four of the 38 benign tumors were considered benign by sonographic criteria. Three of 4 borderline epithelial tumors were considered malignant sonographically, as were 22 of the 26 cancers of the ovary (sensitivity 84%). Nineteen of them were malignant epithelial neoplasms and most were classified as FIGO stages III and IV (76%). In 6 of the 7 patients with stage I and II cancers the latter were considered malignant by sonographic criteria. Twenty-three of the 26 cancers were classified as having a complex structure using the classic ultrasonographic criteria. Histopathological evaluation did not correlate with the ultrasonic findings: sonography could not predict the correct stage and a particular histological type. Nevertheless, ultrasonography is a valuable diagnostic tool as a preoperative procedure in patients with a suspected ovarian neoplasm.

Adolescent↗

Computed tomography prior to second-look operation in advanced ovarian cancer.

Twenty-six patients treated with chemotherapy for ovarian cancer underwent a second-look laparotomy after clinical response (or in the absence of evidence of progressive disease). Abdominopelvic computed tomography (CT) was performed before this operation. Five patients (19%) who had been demonstrated as being free of disease by computed tomography were found to have a tumor larger than 1 cm. Computed tomography sensitivity was good in detection of lymph node metastases (83%), average for pelvic residual tumor (63%) and the omentum (50%), and low for other peritoneal locations (11%). Before second-look operation, the computed tomography scan provides useful surgical information about residual disease in retroperitoneal lymph nodes. However, negative computed tomography findings do not exclude residual tumor or confirm complete remission and therefore cannot replace the second-look laparotomy at this time.

Female↗

The rate of increase in urinary flow rate during micturition: a valuable urodynamic parameter for the diagnosis and differentiation of abnormalities of micturition in women.

The diagnostic significance of the maximum rate of increase in urinary flow during micturition, which is given by the tangent to the urinary flow curve at its point of maximum slope, was investigated at the University of Bern Women's Hospital. The micturition curves of 87 women were evaluated. Twenty four were in the control group, 36 had a variety of pathological conditions, and 27 had simple stress incontinence. For the measurement of urinary flow the bladder was filled until the subject felt the first need to micturate. The urinary stream was measured with an electronic balance (AMS flowmeter) and charted by a felt-pen recorder. In addition, continuous urethrocystotonometry was performed and urine was sampled for bacteriological examination. The results showed clearly that the maximum increase in urinary flow rate is of greater diagnostic value than the maximum and mean urinary flow or the micturition time. It is a simple, non-invasive method for differentiation between normal and pathological micturition curves. The discriminatory power of the test is age-independent. These investigations show that during the phase of active emptying of the bladder the rate of increase in urinary flow is the parameter which provides most diagnostic information.

Diagnosis, Differential↗

Measurement of the transmission factor and stress factor at four points in the urethra in patients with stress incontinence.

The transmission factor and the stress factor (a new parameter introduced by us) were determined at points corresponding to 10%, 40%, 70%, and 90% of the functional length of the urethra in 25 women with stress-incontinence and were used to construct urethral closure pressure profiles. The measurements were made with the patients supine after infusion of 200 ml into the urinary bladder, and in the standing and supine positions following infusion of 300--400 ml. There was an almost linear decrease in the value of the transmission factor along the functional length of the urethra. In the distal third of the urethra we found significant differences in vesico-urethral pressure transmission between patients with differing degrees of stress incontinence. The significance of the transmission factor in the preoperative and postoperative evaluation of urethral closure pressure profiles is discussed.

Adult↗