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Biomedical subjects

E Donoso

Publications and source records attributed to E Donoso.

At least 19 recordsLinked to original sources
PubMed1999

[Count of salivary Streptococci mutans in pregnant women of the metropolitan region of Chile: cross-sectional study].

BACKGROUND: Salivary Streptococci mutans contamination is considered the main microbiological risk factor for the initiation of caries. AIM: To assess the oral health of pregnant women, counting Salivary Streptococci mutants. PATIENTS AND METHODS: One hundred seventy four pregnant women, in the first, second and third trimester of pregnancy, aged 27 +/- 5 years old, consulting at a public primary health center, were studied. Puerperal women that had their delivery two months before, were studied as a control group. Salivary samples were obtained and Streptococci mutans colonies were counted using quantitative and semiquantitative methods. RESULTS: There was a good concordance between both counting methods. No differences in Streptococci mutans counts were observed among the three groups of pregnant women, but the latter as a group had higher counts than puerperal women. Women with more than 5 caries had also higher counts. CONCLUSIONS: Semiquantitative Streptococci mutans counts are easy, rapid and non invasive and have a good concordance with quantitative counts in saliva.

Adult↗
PubMed1999

[Dental fluorosis: quantification of Streptococcus mutans in school children from Mamiña, Chile. A longitudinal study].

BACKGROUND: High fluorine concentrations in drinking water are associated with a decrease in the amount of salivary S mutants. Taking into account that clinical dental fluorosis can appear with 1.5 ppm of fluorine in the drinking water, fluorine concentrations in Mamiña is 2.4 ppm. AIM: To quantify salivary S mutans in school age children from Mamiña, a zone with a high fluorine content in the drinking water, during one year. MATERIAL AND METHODS: During 1997 and 1998, dental health was assessed and salivary samples were obtained from 51 children (27 male) aged 10 +/- 2 years to quantify S mutans. RESULTS: Most children studied had more than 10(5) salivary S mutans colony forming units. No changes in the rates of infection or dental health characteristics were observed during the observation year. CONCLUSIONS: High fluorine content in the drinking water did not have an effect on salivary S mutans infection in this population.

Child↗
PubMed1994

[Intrauterine growth in full-term twins without risk factors].

Twins are analysed according to the intrauterine growth curve constructed for single fetus. The relationship of twins with length, weight, head circumference and the weight length-index is studied. Twins over 36 weeks gestation age, without maternal or fetal pathologies were selected. It is concluded the twins pregnancy "per se" constitutes on its own, a risk factor regarding the intrauterine growth curve, particularly in relation with the weight curve.

Birth Weight↗
PubMed1993

Maternal hemodynamic adjustments in idiopathic fetal growth retardation.

The hemodynamic characteristics of 11 normotensive gravidas with idiopathic fetal growth retardation (FGR), were compared with 11 controls of similar age, parity and body size. At weeks 36-38 of gestation, plasma volume was 3,161 +/- 121 ml in controls and 2,624 +/- 95 ml in the FGR group (p < 0.003); cardiac output (CO) was 6,191 +/- 132 ml/min in controls and 5,483 +/- 186 ml/min in the FGR group (p < 0.01). Total peripheral vascular resistance (TPVR) was lower in controls than in FGR (1,031 +/- 33 vs. 1,306 +/- 62 dyn/s/cm5; p < 0.001). Birth weight was correlated with both plasma volume (r = 0.61; p < 0.01) and CO (r = 0.53; p < 0.02) and inversely correlated with TPVR (r = -0.69; p < 0.001). These results are in line with the hypothesis that a reduced plasma volume leads to a lower CO and, secondarily, to reduced uterine blood flow and FGR.

Birth Weight↗
PubMed1993

Maternal plasma volume expansion and hormonal changes in women with idiopathic fetal growth retardation.

OBJECTIVE: To explore the mechanisms underlying the reduced maternal plasma volume associated with idiopathic fetal growth retardation (FGR). METHODS: In 30 normotensive women with growth-retarded fetuses and 26 with normal-size fetuses, plasma volume was measured with a modified Evan's blue method. Plasma levels of atrial natriuretic peptide, plasma renin activity, aldosterone, estradiol, and progesterone, and urinary excretion of kallikrein, prostacyclin, and thromboxane A2 were measured at 34-40 weeks' gestation. RESULTS: Compared with controls, gravidas with growth-retarded fetuses had a reduced plasma volume expansion (P < .01), similar atrial natriuretic peptide and plasma renin activity levels, and lower serum aldosterone (P < .001) and placental steroids (P < .03). These women also had decreased urinary kallikrein activity and prostaglandin excretion (P < .05). When both groups were combined, maternal plasma volume correlated significantly with birth weight (r = 0.53) and placental weight (r = 0.66). CONCLUSION: Normotensive women with idiopathic FGR have reduced plasma volume expansion. Although the exact mechanisms of this change are unknown, we postulate that the lower maternal aldosterone levels and reduced levels of vasodilator substances, such as prostacyclin and kallikrein, may have a causal role.

Adult↗
PubMed1992

Hemodynamic changes in underweight pregnant women.

Twelve normal-weight and 12 underweight women were compared to test whether fetal growth retardation in underweight gravidas is related to inadequate maternal hemodynamic adjustments. Plasma volume (+/- standard error) was 3227 +/- 103 mL in normal-weight and 2731 +/- 84 mL in underweight women (P less than .002). Cardiac output was 6340 +/- 167 mL/minute in controls and 5689 +/- 213 mL/minute in underweight women (P less than .03). Total peripheral vascular resistance was lower in controls than in underweight subjects (1025 +/- 31 versus 1198 +/- 58 dyne/second/cm5). Mean birth weight was 2837 +/- 125 g in underweight women and 3362 +/- 106 g in controls (P less than .005). Similarly, placental weight was reduced in the underweight group. All infants delivered by control mothers had a normal birth weight, whereas six infants from underweight gravidas were growth-retarded. In all cases combined, maternal plasma volume correlated significantly with both birth weight (r = 0.6, P less than .002) and placental weight (r = 0.56, P less than .01); total peripheral vascular resistance also correlated significantly and inversely with newborn weight and placental weight. Cardiac output correlated only with placental weight (r = 0.54, P less than .02). These results are consistent with the hypothesis that underweight mothers are at higher risk of fetal growth retardation because of a smaller plasma volume and lower cardiac output.

Adolescent↗
PubMed1991

Diffusion of medicaments within root canal dentin. A scanning electron microscopic study.

Root canals of 21 maxillary human teeth were enlarged with reamers and flushed alternatively with sodium hypochlorite and hydrogen peroxide. After its mechanical preparation, root canals were dressed with camphorated paramonochloropherol and/or formocresol delivered by paper points. All three medicaments crystallize both on dentin walls and inside dentinal tubules. The clinical implications of these findings are discussed.

Adult↗
PubMed1991

[Ultrasonographic estimation of fetal weight in intrauterine growth retardation. Comparative analysis of 4 formula].

The accuracy of estimated fetal wight determined by US scan in 70 fetuses with IUGR was analyzed using different formulas. The formula used in our Service showed the best correlation between estimated fetal weight and birth weight (R = 0.92), with estimation error not significant and +/- 8.3% variability. The foreign formulas showed significant estimation error and over 10% variability, therefore, in our population the use of the local formula is recommended.

Birth Weight↗
PubMed1991

[Glycosylated hemoglobin in normal pregnancy].

In a prospective and transverse mode, HbA1 levels were determined in 60 normal pregnant women distributed in 5 groups according to gestational age. Also, total hemoglobin and glycemia levels one hour after a 50 g oral glucose load were determined. No statistically significant differences were found in HbA1 mean level of the different gestational age groups of our study. Correlation of glycosylated hemoglobin and gestational age, total hemoglobin and glycemia was found to be not significant.

Blood Glucose↗
PubMed1985

A role for adrenaline and calmodulin in modulating cyclic AMP levels during the lactogenic cycle.

The effect on lactose production of several external modulators of intracellular cyclic AMP was studied in rat mammary gland tissue slices and explants. Adrenaline, a beta-adrenergic receptor effector, forskolin, a direct adenylate cyclase activator and fluphenazine, a calmodulin inhibitor, all produced an increase in the intracellular level of cyclic AMP and a concomitant inhibition of lactose production. These results suggest a role for adrenaline and calmodulin in modulating cyclic AMP levels in mammary tissue during the lactogenic cycle.

Animals↗