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Biomedical subjects

E Doherty

Publications and source records attributed to E Doherty.

30 records · Page 2Linked to original sources
PubMed1987

Autofluorescence of clofazimine in discoid lupus erythematosus.

A 70-year-old woman developed dark reddish blue pigmentation in scarred areas of discoid lupus erythematosus after taking clofazimine intermittently over a period of 10 years. Although light microscopy of routinely processed tissue failed to define the cause of the pigment, fluorescent microscopy showed vivid red deposits concentrated around larger vessels within the dermis. These deposits were shown to correspond to birefringent red clofazimine crystals on fresh frozen sections. Although the hyperpigmentation may clinically resemble melanin, biopsy specimens from our patient revealed a loss of melanin pigment in lesional skin, suggesting a primary role for clofazimine in producing the color changes observed.

Aged↗
PubMed1987

Neurotropic Melanoma. A variant of desmoplastic melanoma.

In ten cases of neurotropic melanoma, patients presented with nodules composed of amelanotic, deeply infiltrating neuroid fascicles. Only four cases were clinically suggestive of melanoma. In eight of the tumors, a precursor lesion was found histologically and provided a major clue to the diagnosis. In seven cases, the dysplastic precursor was lentiginous, while a superficial spreading pattern was present in one. Initial surgery was often inadequate because of the difficulty in defining tumor margins and the lack of pigment. In seven of the tumors, S100 protein was demonstrated within the invasive spindle cell component by the immunoperoxidase method. This finding was negative in three cases, two of which showed positive staining of the precursor and nerve filaments, indicating that the absence of S100 protein cannot be used as an exclusion criterion for neurotropic melanoma.

Adult↗
PubMed1980

Financial well-being among the aged: a further elaboration.

This study represents a further elaboration of the relative deprivation model proposed and tested by Liang and Fairchild (1979). A central assumption underlying this inquiry is that the link between economic status and perceived financial adequacy is mediated by subjective interpretations of the situation such as relative deprivation (Stouffer et al., 1948) and distributive justice (Homans, 1961). In addition, the effects of ascribed status variables such as age, sex, race, and religion on the social comparison process are assessed. Data for this investigation came from a survey of 252 older people in the Detroit area. Findings indicate that financial satisfaction is directly influenced by relative deprivation and distributive justice, while it is only indirectly affected by social status, labor force participation, and income. Race and age are the two ascribed statuses which have a significant impact on social comparison and perceived income adequacy. Implications of these results in terms of theory building and the design of income maintenance policies are also suggested.

Aged↗