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E Del Pozo

Publications and source records attributed to E Del Pozo.

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Reversion by calcium but not by Bay K 8644 of neuromuscular blockade induced by nicardipine.

We compared the effects of nicardipine on indirectly and directly elicited twitches in phrenic-hemidiaphragm preparations from rats, and the effects of calcium and Bay K 8644 on nicardipine-induced neuromuscular blockade. Nicardipine (5-250 microM) decreased both directly and indirectly elicited muscular contractions in a concentration-dependent way. The inhibitory effect was greater when the preparation was indirectly stimulated. Nicardipine antagonism of indirectly elicited contractions was reversed in an apparently competitive way by calcium (1-4 mM). In contrast, the calcium channel agonist Bay K 8644 (0.1 and 1 microM) had no effects per se, nor did it reverse neuromuscular blockade induced by nicardipine. Interestingly, Bay K 8644, at 10 microM, decreased the height of indirectly elicited muscular contractions. These results suggest that the calcium antagonist nicardipine affects neuromuscular transmission to a greater degree than muscular contraction, this effect being antagonized by calcium. In contrast, the calcium agonist Bay K 8644 was unable to produce any effect as stimulator of calcium channels at the neuromuscular level, indicating that this drug may exhibit tissue specificity.

3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethy↗