Biomedical subjects

E Decuypere

Publications and source records attributed to E Decuypere.

At least 73 records · Page 4Linked to original sources

PubMed2003

Effects of storage time on incubating egg gas pressure, thyroid hormones, and corticosterone levels in embryos and on their hatching parameters.

Incubating eggs (1,800 total) produced by a commercial flock of Cobb broiler breeders were used to determine the effects of storage duration (3 and 18 d) on gas partial pressure, thyroid hormones, and hatching parameters. Partial pressure of oxygen (pO2) and carbon dioxide (pCO2) were measured on d 18 and at internal pipping (IP) during incubation. Blood samples were collected for determination of triiodothyronine (T3), thyroxine (T4), and corticosterone concentrations in the embryos at IP and in newly hatched chicks. From 464 to 510 h of incubation, eggs were checked individually every 2 h to determine the timing and duration of IP, external pipping (EP), and total hatching time. At 18 d of incubation and at IP, pCO2 was greater in air cell of eggs stored for 3 d compared to those stored for 18 d (P < 0.05), but pO2 was greater in eggs stored for 18 d. At IP, T3 and corticosterone levels were higher in plasma of the embryos of eggs stored for 3 d compared to those stored for 18 d, but it was the reverse in newly hatched chicks (P < 0.05). Embryos from eggs stored for 18 d required more time to complete IP compared to embryos of eggs stored for only 3 d (P < 0.05), whereas the duration of EP was not affected by storage. The overall longer incubation was, however, not only due to prolonged IP but also to later occurrence of IP. It was concluded that prolonged IP as a result of long storage may be related to the late increase in corticosterone level, which may be a necessary stimulus for higher T3/T4 ratio, late increase in pCO2 level, and decrease in pO2. The effect of long storage was a delay in hatching and a continuous increase in T3 due to higher corticosterone levels between IP and hatching, which may be an indication of the more stressful event of hatching of embryos from eggs stored longer. Differences in pCO2, pO2, T3, T4, and corticosterone levels in the incubating eggs may be manifestations of these changes culminating in altered hatching parameters and consequently differences in chick quality and growth potentials.

Animals↗

PubMed2003

Performance and physiological parameters of broiler chickens subjected to fasting on the neonatal period.

Broiler chicks aged 12 h after hatching were allotted according to a block design in a 7 x 2 factorial schedule of 14 treatments and four replications of 50 chicks each one. The main experimental factors were fasting for 0, 6, 12, 18, 24, 30, and 36 h after chick placement and sex. Independent of sex, fasting had a negative linear effect on weight and productivity of broilers at market age (42 d) without affecting feed conversion or mortality index. Groups subjected to 18 and 36 h of fasting after placement, corresponding to 30 and 48 h posthatching fasting, had lower biometrical values for small intestine (length, weight, and size; villus height; and crypt depth) than chicks fed immediately after placement. According to the Pearson test, BW of birds at 21 and 42 d were significantly correlated to BW at 7 d (r=0.77) and 21 d (r=0.45), respectively. Males performed better than females but had higher mortality rates. Fasting did not influence serum concentrations of corticosterone or sexual steroid hormones. Nevertheless, early signs of sexual dimorphism arose from the high estradiol (E2) concentration on female serum. Heterophil:lymphocyte ratio was not different among treatments, indicating that early fasting did not seem to be a stress factor 21 or 42 d after fasting. The results suggested a maximum fasting of 24 h after hatching in order to preserve broiler productivity at market age.

Aging↗

PubMed2003

Beneficial effects of alternative lighting schedules on the incidence of ascites and on metabolic parameters of broiler chickens.

The beneficial effects of different lighting programmes on the incidence of ascites was investigated in an experiment with 360 three-day-old male broiler chickens. At 3 days of age, chicks were randomly divided over three rooms in a high-altitude farm, 2000 m above sea level. During days 14 to 28 ambient temperature decreased during the night but the minimum temperature did not descend below 15 degrees C. In the first room the continuous lighting schedule (CL, 23L:1D) was maintained and in the second room an intermittent lighting schedule (IL, 1L:3D), repeated six times daily, was imposed from 3 days of age. In the third room, an increasing photoperiod schedule (IP, 4 to 14 days, 6L:18D; 15 to 21 days, 10L:14D; 22 to 28 days, 14L:10D; 29 to 35 days, 18L:6D; 36 to 42 days, 23L:1D) was provided. Mortality associated with right ventricular failure and ascites was numerically lower in birds reared under the IL and IP schedules compared to birds reared under the CL schedule, which can be attributed to the temporary reduction in relative growth and feed intake in IL and IP birds. It was concluded that the beneficial effect of lighting schedules could be due to a reduced metabolic rate as a consequence of the altered growth trajectory, as also reflected in the lower haematocrit and plasma T3 levels of IL and IP birds compared to CL birds.

Animal Feed↗

PubMed2002

FSH- and LH-cells originate as separate cell populations and at different embryonic stages in the chicken embryo.

The histological distribution of gonadotrophs containing either LH or FSH, but not both gonadotropins, has been demonstrated before in the juvenile and adult chicken throughout the caudal and cephalic anterior pituitary lobes. In the present investigation, the distribution of FSH- and/or LH-containing gonadotrophs was further investigated in the chicken embryo by use of the same homologous antibodies as used in our earlier study. Fluorescent dual-labeling immunohistochemistry revealed that during embryogenesis LH and FSH reside exclusively in separate gonadotrophs, as has been described before in the post hatch bird. LH-immunoreactive cells were observed for the first time at day 9 of embryogenesis. This is as much as 4 days earlier than the FSH-immunoreactive cells, which appeared at day 13 of embryogenesis. Our results confirm that FSH- and LH-containing gonadotrophs are distributed throughout both lobes of the anterior pituitary. No conspicuous differences were observed between the sexes in any of the aspects investigated. The described situation is unique in that it seems to imply the existence of separate cell lineages for FSH- and LH-producing cells, as opposed to the single gonadotrope lineage described in all other species studied so far, with the exception of bovine. Our data indeed raise the question as to which signaling and/or transcription factors may cause the unique dichotomy observed in the chicken gonadotrophs.

Animals↗

PubMed2002

Measuring the eggshell strength of 6 different genetic strains of laying hens: techniques and comparisons.

1. Eggshell quality was compared in 6 different strains of laying hens. Three strains were commercial; the three others were experimental. 2. Four different variables describing the strength of eggshells were investigated. Three of them were the classical ones eggshell thickness, shell stiffness measured during quasi-static compression and breaking force. Dynamic stiffness, introduced by Coucke (Ph.D. Thesis, KU Leuven, 1998), was the 4th. The fact that this measurement is dynamic could be helpful in genetic selection for eggshell breakage, because forces applied to the egg in practice are dynamic, rather than static. 3. Hisex White hens produce eggs with the strongest eggshell, in terms of all 4 eggshell variables. However, their shell quality in terms of breaking force did not remain constant over the laying period, unlike 4 other strains. 4. All strains showed a decline in quasi-static stiffness over time. 5. The eggshell thickness of three strains showed a decline over time. 6. Dynamic stiffness remained constant or improved in all strain. 7. All variables describing the mechanical eggshell strength gave different information.

Animals↗

PubMed2002

Further evidence for the involvement of cardiac beta-adrenergic receptors in right ventricle hypertrophy and ascites in broiler chickens.

The present study was carried out to determine, first, the cardiac beta-adrenergic receptor characteristics of broiler chick embryos exposed to two different CO(2) levels during the last stage of embryonic development, and second, the prophylactic effect of beta(1)-adrenoceptor blocker on right ventricular hypertrophy in broiler chickens. High CO(2) embryos showed significantly higher haematocrit values, higher partial pressure of CO(2) levels and lower partial pressure of O(2) levels than those of normal CO(2) embryos. Exposure of chick embryos to high CO(2) levels reduced the binding capacity of myocardial beta-adrenergic receptors compared with those embryos incubated at the normal CO(2) level. Atenolol-supplemented diet numerically reduced ascites incidence in broiler chickens (7%) compared with birds fed the control diet (15%). In conclusion, these data support the important role of the beta-adrenergic receptor in the cardiovascular system for cardiac output, and secondary to pulmonary hypertension syndrome.

Animals↗

PubMed2002

Effect of induced molting on albumen quality, hatchability, and chick body weight from broiler breeders.

Commercial Cobb broiler breeders were subjected to molting from 55 to 62 wk of age. Incubating eggs were collected before molting and after molting and were stored for 18, 13, 8, or 3 d. Sample eggs were broken to measure albumen Haugh units (HU) and pH. Two hundred twenty-five eggs per treatment, stored for 18, 13, 8, or 3 d, were incubated for 21 d; the hatched chicks were weighed at the end of incubation and again after Day 7 of rearing. As the storage time increased, albumen HU decreased (P < 0.001). At all storage times, HU after molting were higher than those before molting (P < 0.001). Albumen pH increased with storage time (P < 0.001). A molting x storage interaction on pH was observed after 8 d of storage (P = 0.03). Hatchability of eggs increased after hens were molted, if the eggs were stored for a long time (P < 0.001). Body weights of 1-d-old chicks from the eggs of hens before molt were heavier than those from eggs after molting (P < 0.001). Conversely, at 7 d, the chicks from the eggs after molting were significantly heavier than those from eggs before molting (P < 0.001). We concluded that molting was a procedure to improve hatchability and chick juvenile growth. If eggs need to be stored, we recommended that fresh eggs with high HU value be stored rather than those with low HU values.

Aging↗

PubMed2002

Somatotrophic and thyroid hormones around the onset of lay in broiler breeders under different conditions.

Somatotrophic and thyroid hormones were determined around the onset of reproduction in broiler breeders reared in two different housing systems [dark, close-sided house (CH) and conventional, open-sided house (OH)]. In both groups age-related changes were obvious for thyroxine (T4), growth hormone (GH) and insulin-like growth factor (IGF-1); levels of T4 decreased, especially between 24 and 28 weeks in both groups; concomitantly GH sharply increased over the same period. A transient peak in triiodothyronine (T3) occurred between 25 and 27 weeks. The effect of housing was only present after the onset of lay. Between weeks 27-28 and the end of the period studied, the CH group showed higher levels of GH and T3 but lower T4 levels as compared to the OH group. A significant increase in GH after onset of lay, without any significant rise in T3 or in IGF-I, could point to a relative insensitivity to high plasma GH levels. Changes at GH receptor level, together with an increased pituitary GH secretion and/or decreased GH turnover may be expected. This may indicate that hypothalamo-pituitary changes at the onset of lay not only imply changes of gonadotrophic cell function, but also other hormonal axes. The relatively decrease in T4 without changes in T3, may point to a decrease in the activity of the thyrotropic axis.

Aging↗

PubMed2001

Developmental expression of activin/inhibin alpha- and beta(A)-subunit genes in the gonads of male and female chick embryos.

The expression of inhibin alpha- and beta(A)-subunits was investigated in gonads of male and female chick embryos during the last week of their 21-day incubation period. Fertilized Hisex brown laying hen eggs were incubated at 37.8 +/- 0.2 degrees and 60% relative humidity in an automatic forced-draft incubator with constant lighting. Embryos were killed after 14, 18, and 21 days of incubation, sexed by macroscopical inspection of the gonadal phenotype, and further dissected to obtain the gonads. Total RNA was isolated using the ultraspec RNA method. The expression of alpha- and beta(A)-subunits was evaluated by competitive RT-PCR. Significant differences were found within and between sexes in the expression of the alpha- and beta(A)-subunits. The level of the alpha-subunit in the testis was about 23-fold higher than that in the ovary at all ages. Testicular content of inhibin alpha mRNA levels was similar at days 14 and 18 but declined significantly at day 21 of incubation, whereas no significant differences were observed between the three age groups in the ovary. Testicular and ovarian inhibin beta(A)-subunit increased significantly from day 14 to day 18 followed by a significant decline before hatch. However, inhibin beta(A) level at day 14 was significantly higher in the ovary than in the testis. At days 18 and 21, there were no differences in the levels of the inhibin beta(A) in the sexes. The expression of inhibin beta(A)-subunit in the ovary was significantly higher than that of the alpha-subunit at all ages. In the testis, however, the expression of the beta(A)-subunit was higher at days 18 and 21 than at day 14. The sex difference in gonadal inhibin subunits expression suggests differential roles of inhibin/activin in the development of the chicken gonads. The changing level of expression during incubation also suggests changing biological roles within sexes.

Activins↗

PubMed2001

Quantification of growth hormone receptor extra- and intracellular domain gene expression in chicken liver by quantitative competitive RT-PCR.

The very sensitive competitive reverse transcription-polymerase chain reaction (RT-PCR) was used to investigate the expression of the extracellular (GHRe) and intracellular (GHRi) parts of the growth hormone receptor (GHR) in the liver tissue of chickens. Two competitors (internal standards), pGHRi MUT and pGHRe MUT, specific to the GHRi and GHRe genes, respectively, were constructed by site-specific mutagenesis. The internal standards defined PCR products of 394 bp for the pGHRi MUT and 330 bp for the GHRe MUT. These were used as competitors to the wild-type GHRi or GHRe which defined PCR products of 382 and 328 bp, respectively. Coamplification, under standardized conditions, of the native RNA in competition with serial dilutions of the mutant RNA in the same PCR reaction followed by enzymatic digestion produced the expected sizes of internal standard cDNA and predicted target cDNA. Expression levels of GHRe and GHRi were determined from standard curves generated. The method was sensitive enough to detect expressions down to picogram levels. Applying this method, the effect of GH and T(3) injection on GHRe and GHRi mRNA expression was determined in the liver of adult female Hisex birds and 1-day-old normal and dwarf chickens. Intravenous GH injection (25 microg/kg body weight) increased plasma levels of GH in Hisex birds after 10 min but rapidly decreased at 60 min followed by an increase in T(3). GH injection significantly increased the expression of the GHRe 60 min after injection but not at 10 min, when the GH level in plasma was high. In the liver of saline-treated dwarf (dw) and nondwarf (Dw) chicks, the level of expression of GHRe was similar in both strains despite disparate levels of basal GH and T(3). However, the level of GHRi was higher in Dw than in dw chicks. Although GH levels increased in both strains after intravenous GH injection (250 microg/kg body wt), the expression of GHRe in both strains was unaffected. However, the mRNA for the GHRi was significantly depressed by injection in the Dw but unaffected in dw chicks. Intravenous injection of T(3) (0.5 and 5 microg/kg body wt) increased plasma levels in both strains but caused depression of GHRi in Dw but not in dw chicks. T(3) injections had no effect on GHRe in either Dw or dw chicks. It is concluded that the expression of the GHRe in adult chickens is GH regulated either directly or indirectly. In contrast, in 1-day-old chicks, GH or T(3) had no effects on the GHRe but regulated the expression of GHRi in Dw chicks, whereas in dwarf chicks both had no effect on GHRe or GHRi expression. It is postulated that GHRe and GHRi gene expression may be regulated by different agonists/antagonists in different strains and depending on the age of the chicken.

Aging↗

PubMed2001

Developmental changes in thyrotropic and somatotropic effect of TRH in precocial Japanese quail and altricial European starlings.

The thyrotropic and somatotropic effects of thyrotropin releasing hormone (TRH) in precocial Japanese quail (Coturnix japonica) and altricial European starlings (Sturnus vulgaris) during postnatal ontogeny were studied. Concentrations of thyroid hormones (TH) and growth hormone (GH) in the circulation were determined 60 min after the subcutaneous administration of TRH. In quail, TRH caused an increase of triiodothyronine (T(3)) in plasma during the phase of rapid growth, whereas thyroxine (T(4)) concentrations were not affected. In starlings, with a different developmental pattern of TH concentrations, TRH induced an increase of plasma T(3) concentrations on all analyzed days, whereas a significant increase of T(4) occurred on day 1 only. Concentrations of GH were stimulated by TRH in both species. Although growth rate is nearly two times higher in starlings than in quail, differences in the control of the thyrotropic and somatotropic axes do not parallel this difference and tissue sensitivity to other hormonal signals are expected in both developmental strategies.

Animals↗

PubMed2001

Teratological studies in defatted jojoba meal-supplemented rats.

To look for possible developmental effects in the offspring of jojoba meal-treated Wistar rats, and to distinguish between the effects of reduced food intake and the specific developmental effects of jojoba meal itself, mated female rats were divided into three groups of 20 rats. They received during gestation: (a) normal rodent food (control group); (b) normal rodent food supplemented with 3% defatted jojoba meal (jojoba group); or (c) normal rodent food pair-fed with the jojoba group (pair-fed group). The jojoba meal group showed approximately 30% inhibition of food intake. Ten rats from each group were killed on gestation day 21. Compared to the control group, foetal body weight was reduced in both the jojoba and pair-fed groups, with a greater reduction in the jojoba group. Skeletal ossification was retarded to the same extent in both the jojoba and pair-fed groups. The other 10 rats from each group were left to produce litters. Compared with controls, the body weight of the pups was lower in both the jojoba and pair-fed groups; the reduction was slightly greater in the jojoba group, but this difference disappeared after 1 week. The offspring showed no other abnormalities and reproduced normally. We conclude that, at the dose used, the retardation in foetal skeletal ossification, induced by jojoba meal supplementation during gestation, is due to food intake inhibition. Moreover, the lower birth weight of the young of jojoba-treated dams compared with the pair-fed group is merely due to a lower body weight gain during gestation.

Abnormalities, Drug-Induced↗

PubMed2001

Synergetic effect of pimozide and thyrotropin releasing hormone on prolactin and thyrotropin release during the drying off of ewes.

The effect of pimozide and/or TRH was investigated on plasma prolactin, thyrotropin, T(4) and T(3) and udder distension in 38 ewes during drying off by feed restriction. The effect of daily injections of 2mg pimozide (s.c.), combined or not with TRH stimulation (200µg, i.v.) on three different days of the drying off period was examined. Blood samples were taken twice daily in each group for 9 days, while blood sampling on the days of TRH injection was also performed at 0, 15, 30min, and 1, 2 and 4h post-injection. Plasma was assayed for PRL, TSH, T(4) and T(3) levels. Udder distension and mastitis incidence were recorded at the end of the drying off period. TRH and pimozide both resulted in elevated plasma PRL levels and acted in a synergetic way. Udder distension and the incidence of mastitis was only influenced by pimozide. The TSH as well as the T(3) response to TRH was increased in ewes under a continuous influence of pimozide and T(3) peaks following TRH injection occurred earlier than T(4) peaks. The higher effect of pimozide upon TRH stimulated PRL and TSH release at day 8 compared to days 0 and 3 indicates a progressive involvement of dopamine on the inhibition of PRL and the sensitivity of the thyrotrophs to TRH during drying off.

Journal Article↗

PubMed2001

Identification of 4,5-didemethyl-4-O-alpha-D-glucopyranosylsimmondsin and pinitol alpha-D-galactosides in jojoba seed meal (Simmondsia chinensis).

The isolation and identification of two pinitol alpha-D-galactosides from jojoba meal are described. The products were isolated by a combination of preparative HPLC on silica gel and TLC on amino silica gel and were identified by MS, NMR spectroscopy, and chemical derivatization as 5-O-(alpha-D-galactopyranosyl)-3-O-methyl-D-chiro-inositol or 5-alpha-D-galactopyranosyl-D-pinitol and 2-O-(alpha-D-galactopyranosyl)-3-O-methyl-D-chiro-inositol or 2-alpha-D-galactopyranosyl-D-pinitol. The same preparative HPLC method on silica gel allowed a new simmondsin derivative to be isolated and identified as 4,5-didemethyl-4-O-alpha-D-glucopyranosylsimmondsin mainly by NMR spectroscopy and high-resolution mass spectrometry.

Acetonitriles↗

PubMed2001

The effects of dietary L-carnitine supplementation on the performance, organ weights and circulating hormone and metabolite concentrations of broiler chickens reared under a normal or low temperature schedule.

1. The present study examined the effects of the addition of 100 mg/kg L-carnitine to the basal starter (containing 17.8 mg/kg L-carnitine) and finisher (containing 22.9 mg/kg L-carnitine) diets on performance, organ weights and plasma hormone and metabolite concentrations of male and female broiler chickens. The broiler chickens were reared either in a room with a normal temperature (NT) program or with a low temperature (LT) program (rapid decrease from 28 degrees C to 20 degrees C at 14 d of age). 2. Broiler chickens reared under the LT schedule consumed more food and attained a greater body weight at 42 d of age than their counterparts reared under NT schedule, without any difference in food efficiency or abdominal fat content. Dietary L-carnitine supplementation had no significant effects on any of these production parameters, except for a reduction in the abdominal fat content of female NT chickens. However, the LT schedule and dietary L-carnitine supplementation greatly increased absolute and proportional heart weights. The elevated heart weights were not due to right ventricle hypertrophy. 3. Both the LT program and L-carnitine supplementation increased circulating plasma triiodothyronine concentrations. There were also some transient effects of both experimental variables on plasma growth hormone, glucose and triglyceride concentrations. 4. L-carnitine did not improve broiler performance. However, this result does not mean that L-carnitine supplementation cannot have beneficial effects in other circumstances. In view of the elevated proportional heart weights, it can also be argued that L-carnitine is a potential agent for reducing the incidence of metabolic diseases in broiler chickens.

Adipose Tissue↗

PubMed2001

Effects of strain, hen age and transferring eggs from turning to stationary trays after 15 to 18 days of incubation.

1. A total of 39,000 eggs (260 incubation batches) produced by Hybro, Cobb and Ross were studied. They were transferred from incubators to hatchers at day 15,16,17 or 18 of incubation. 2. Hatchability increased in proportion to the day of transfer and it was higher when the transfer occurred at day 18, whereas the differences between hatchability for days 15, 16 and 17 were not significant. 3. The hatchability of the Hybro eggs was more affected by the transfer time, as were the eggs of the older flock (51 weeks and more). 4. The percentage of unhatched embryos increased with the age of the breeders and decreased with the day of transfer. In addition, the percentage of unhatched embryos was affected by the strain of hen. 5. It was concluded that transfer time has to be considered in order to optimise hatchability and chick quality, especially if the eggs from older flocks are incubated.

Age Factors↗

PubMed2001

Effect of whole-body vibration in the vertical axis on cortisol and adrenocorticotropic hormone levels in piglets.

Vibration, being a consequence of motion during transport, may impair the welfare of pigs. Therefore, the primary objectives of this study were 1) to evaluate during transport simulation the use of ACTH and cortisol plasma levels, which are part of a basic adaptation mechanism of pigs and 2) to define comfort conditions for pigs related to the frequency and acceleration of vibration. Pigs with a body weight between 20 and 25 kg were vibrated in the vertical direction for 2 h at 2, 4, 8, and 18 Hz, in combination with root mean square acceleration magnitudes of 1 or 3 m/s2. Blood was sampled at regular intervals before, during, and after vibration as the pig's behaviors were recorded. Data on ACTH, cortisol, and behavior could be collected from 104 vibrated pigs and 21 controls. In addition, eight animals (3 controls, 5 vibrated) were treated with 0.1 mg of dexamethasone/kg BW, eight animals (3 controls, 8 vibrated) with 0.1 mg naloxone/kg BW, and six (2 controls, 4 vibrated) with a physiological salt solution. Blood samples were taken and products were administrated via an intravenous catheter. The pigs spent less time lying during both hours of vibration treatment than during control conditions. Compared with 2 and 4 Hz, time spent lying was 10 times shorter at 8 Hz and 18 times shorter at 18 Hz. At 1030, ACTH levels were significantly higher than basal levels in animals vibrated at 2 (P < 0.0001), 4 (P < 0.002), and 18 Hz (P < 0.0006). After 1 h, levels returned to basal values. Cortisol levels increased very rapidly after the beginning of vibration (P < 0.0001) and remained higher until 1 h after cessation of vibration (P < 0.003). An inferrence of the lines of equal responses for ACTH and cortisol indicated that, in the beginning of vibration exposure, pigs were extremely susceptible to vibrations at lower frequencies (2 and 4 Hz), whereas at the end of vibration exposure the responses were higher at 18 Hz. The application of dexamethasone and naloxone underpinned the emotional component of the response strategy of pigs to vibration. Hence, vibration during transport should be minimized in order to enhance the adaptive capacities of pigs.

Adaptation, Physiological↗

PubMed2000

Litter size, ovulation rate and prenatal survival in relation to ewe body weight: genetics review.

Lamb's birth weight and litter weight were found to be related to ewe weight. Deviations from generally applicable formulae indicated an interaction between the genotype of the lamb and the maternal environment, as suggested in egg transfer experiments. Land's (1977) hypothesis on the spare conceptus capacity, when comparing large and small breeds within a species, with respect to prolificacy, was more applicable to genetically homogeneous groups within a breed than between breeds and lines within a breed. A hypothesis suggests that variation in the within breed genetic correlation between ewe weight and prolificacy may largely depend on the relative uniformity of selection criteria applied. It can further be argued whether selection based on body weight or growth rate, compared to selection on reproductive performance, could be important sources of within breed as well as among breed variations in the genetic correlation estimates between ewe weight and prolificacy. The dynamics of the genetic correlation between ewe weight and prolificacy has an effect of long-term selection for body weight, growth rate and reproduction traits. This leads to the problem of the relative incompatibility of selection of an association between body proportions with reproductive traits, especially in meat type breeds. There is a parallellism or antagonism in the genetic correlations between ewe weight and prolificacy as compared to those between ewe weight and other reproduction traits. The within breed relationship between ewe weight and ovulation rate was found to be positive in some breeds. The effects of body condition at mating were contradictory. Genotypexenvironment interactions were observed in certain cases. Among most breeds, differences in ewe weight were unrelated to differences in ovulation rate. There were no relationships between ewe weight and prenatal survival within breeds or in lines within a breed. However, there exists a differential relationship between ovulation rates and prenatal survival rates in relation to ewe weight, depending on the selection criteria applied. A clearcut relationship between litter weight components and ewe weight cannot be generalized but may vary among differentially selected breeds and lines within them. This is a final, unifying and unresolved question.

Journal Article↗