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E Davis

Publications and source records attributed to E Davis.

At least 109 records · Page 6Linked to original sources
PubMed1982

Immunochemical CK-MB assay for myocardial infarction.

The diagnostic efficiency of an immunochemical assay for CK-MB (I-MB) was compared with that of an electrophoretic procedure for this isoenzyme (E-MB) in 215 consecutive patients in whom acute myocardial infarction (MI) was clinically suspected. All patients were investigated with a standard protocol consisting of serial assays of total creatine kinase (CK) and lactic dehydrogenase (LD) activities, CK-MB and LD1 isoenzymes, and electrocardiograms. Technetium pyrophosphate cardiac scans were obtained for eleven patients; autopsy was performed in six cases. The diagnosis of acute MI was established in 45 patients. The coefficients of variation for the intra-assay and interassay precision of I-MB assay ranged from 2.05%-7.2%. Concordance between the I-MB and E-MB results at the decision values for acute MI was observed in 203 of 215 patients (94.4%). At the cut-off point of 10 U/L, the I-MB assay was 95.5% sensitive and 95.3% specific for acute MI; the corresponding rates for the E-MB test were 93.3% and 94.7% respectively. The test efficiency rate for I-MB assay was 95.3% and that of E-MB procedure 94.4%. A complete time-based isoenzyme protocol for the diagnosis of acute myocardial infarction has several variables; the need for interpretation of individual profiles and for the preparation of a formal report is discussed.

Clinical Enzyme Tests↗
PubMed1982

Effects of acute cold exposure on muscle amino acid and protein in rats.

To test the effects of acute cold on muscle amino acid and protein 1) rats were exposed to 4 degrees C for 24 h, functionally hepatectomized (eviscerated) and accumulation in the blood used to indicate changes in amino acid release from the tissues; 2) other rats were left intact, and urinary excretion of 3-methylhistidine (proportional to muscle protein breakdown) determined during cold exposure. In the eviscerated group, cold enhanced loss of total amino acids from the tissues (as alpha-amino nitrogen), but the loss (213 +/- 14.8% of basal in 2 h) was not due to excess alanine (180 +/- 8.5%). By comparison, in fasted rats total amino acid was 182 +/- 12.3, alanine 309 +/- 17.2%. Also, the cold-induced loss resembled the effects of streptozotocin diabetes and depended on a depression by cold of serum insulin (to 35.7 +/- 2.3 muU/ml). Therefore it was prevented when insulin was restored by infusion (40 mU . 100 g-1 . h-1) or by adrenodemedullation before cold exposure. Epinephrine (10 micrograms/100 g sc) depressed insulin in the latter and permitted amino acid release to recur. In intact rats, 3-methylhistidine excretion was unaffected by cold. The results suggest that although cold fails to stimulate alanine synthesis or protein breakdown, it inhibits insulin release sympathetically, thereby diminishing the amount of amino acid incorporated into muscle protein.

Adrenal Medulla↗
PubMed1981

Iodine-131 levels in sludge and treated municipal wastewaters near a large medical complex.

Iodine-131 was found to dominate the gamma spectra of dried sludge and concentration liquid effluent samples from a sewage treatment plant serving the area containing the Texas Medical Center in 1975. The concentration of Iodine-131 varied considerably on a time scale of weeks but was fairly stable in the course of a single day. The partition of Iodine-131 between the dried sludge and the liquid effluent was found to be reasonably constant during the sampling period. Knowledge of the concentration in these phases and the daily output of sludge and effluent let to be estimate of an annual discharge of over one Curie of Iodine-131. Circumstantial evidence linking this discharge to the practice of nuclear medicine in the area is considered strong, but an attempt to correlate variation in the effluent activity with actual nuclide use was inconclusive due, among other reasons, to an insufficient clinical data base. An analysis of possible exposure pathway indicated that negligible human exposure resulted from the Iodine-131 released primarily because the receiving body of water is a saline industrial waterway. A more extensive analysis would be in order for a similar plant discharging treated wastewaters into an inland water system.

Academic Medical Centers↗
PubMed1980

Training cognitive functioning in the elderly--inability to replicate previous findings.

This study was designed to replicate Hornblum and Overton's study which trained conservation ability in elderly women [1]. Thirty-four elderly women volunteers were given a pretest battery of area and volume conservation tasks; participants also completed an extensive life history questionnaire. Conservation scores were the highest yet recorded by elderly participants. Thirty-two women received perfect conservation scores; only two were "partial conservers"; no participant was a "nonconserver." Consequently, training was not implemented. These women had high levels of education, good health, adequate income, satisfying leisure activities, and positive attitudes about aging. Advanced chronological age does not guarantee poor conservation performance. The mechanism(s) whereby life history variables influence cognitive functioning needs to be determined.

Aged↗
PubMed1980

Tel-Med.

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Health Education↗