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Biomedical subjects

E Daniele

Publications and source records attributed to E Daniele.

At least 37 records · Page 2Linked to original sources
PubMed1988

Substance P as a transmitter in the human ciliary muscle.

The present experiments, carried out on the human fresh ciliary muscle, were undertaken to define whether substance P is involved as an excitatory transmitter in the contractile response evoked by electrical stimulation. Our results show that, following cholinergic and adrenergic blockade, the resistant component of contraction was completely abolished by (D-Pro2-D-Trp7,9)-SP, a synthetic analogue of substance P with antagonistic activity. Moreover the effects of exogenous substance P were investigated.

Ciliary Body↗
PubMed1988

Extracardiac rhabdomyoma: An immunocytochemical study and review of the literature.

Two cases of 'adult' rhabdomyoma and 2 of 'fetal' rhabdomyoma have been immunologically studied using several antisera specific of skeletal muscle fibers proteins. This paper also deals with a review of the literature on these rare benign skeletal muscle proliferations. It is concluded that 'adult' rhabdomyoma contains fetal myosin and therefore the term 'adult' does not seem immunologically appropriate any longer. In addition the tumoral cells show the same level of differentiation as seen in neonatal skeletal muscle. Therefore it seems that the definition of neonatal rhabdomyoma is more appropriate for these benign muscular proliferations. The 2 cases of fetal rhabdomyoma appear phenotypically similar to normally developing myoblasts and contain fetal myosin. Therefore it seems that the definition 'fetal' is here appropriate for what appears to be a disorganized proliferation of otherwise normal fetal skeletal muscle fibers. The differential diagnosis between these latter tumors and rhabdomyosarcomas has been discussed.

Adult↗
PubMed1988

Uterine sarcomas. A retrospective study of 17 cases.

Seventeen documented cases of uterine sarcoma were studied in an effort to establish the relationship between prognostic factors and patients' survival. The analysis of prognostic factors showed that there was a significant difference in survival between patients with stages I and II tumors and those with more advanced lesions. It has been also noted that prognosis was worse in patients with history of previous abortions and in patients who had abdominal or pelvic pain.

Aged↗
PubMed1984

Influence of pH on the responses of guinea-pig isolated trachea to sympathomimetic amines.

Sympathetic amines were tested on isolated trachea of guinea pig at physiological (7.4) and acid (6.6) pH. At physiological pH noradrenaline and phenylephrine relaxed the spontaneous tone of the tracheal muscle preparation; when propranolol was previously added to the organ bath solution, noradrenaline and phenylephrine didn't affect the tracheal muscle tone. Tested at acid pH (6.6), noradrenaline and phenylephrine still relaxed tracheal muscle preparations, but in the presence of propranolol these drugs increased the muscle tone. The spasmogenic effect produced by noradrenaline and phenylephrine after beta-receptor blockade by propranolol, was completely abolished by phentolamine. The present results suggest that acidosis could alter the responsiveness of both alpha- and beta-adrenoceptors in the tracheal muscle of guinea pig.

Animals↗
PubMed1984

The effect of thymoxamine on guinea-pig ileum contractions.

The effects of thymoxamine on the contractions induced in guinea-pig isolated ileum were examined. The drug was tested in a large range of concentrations (10(-8)-10(-4) M). The twitch response induced by acetylcholine was potentiated by low concentrations and inhibited by high concentrations of the alpha 1-blocking drug thymoxamine. The contractions in response to carbachol were always inhibited. Thymoxamine also affected the responses of the ileum to other stimulants: angiotensin, pentagastrin, cholecystokinin. The drug (8 X 10(-5), 5 X 10(-4) M) inhibited the calcium contraction of high K+ depolarized preparations.

Animals↗
PubMed1983

Diclofenac sodium in ureteral colic: a double-blind comparison trial with placebo.

A randomized prospective double blind study of the analgesic effect of 75 mg intramuscular diclofenac sodium (Voltaren), a potent prostaglandin synthetase inhibitor, versus placebo (saline solution) was carried out in 131 consecutive patients with acute ureteral colic. Diclofenac provided complete relief of pain 25 minutes after the injection in 59% of the cases, while placebo provided relief in 29% (p less than 0.01). Forty patients in the placebo group and seventeen patients in the diclofenac group needed an open injection of 75 mg diclofenac intramuscularly after 25 minutes due to persistent pain. Fifty-four of the fifty-seven patients treated with an open injection of diclofenac achieved complete relief of pain after 30 minutes. There were no side-effects of the treatment.

Adult↗
PubMed1983

[Choroidal metastasis of a testicular embryonal carcinoma].

A rare case of choroidal metastasis of testicular embryonic carcinoma origin is described, and pathologic features illustrated. The differential diagnosis of primary and metastatic ocular tumors is discussed. Because of the possibility of a primary ocular origin of this tumor and its rapid clinical evolution, the need to perform a systematic search for a primary testicular carcinoma in young male patients is emphasized.

Adult↗
PubMed1981

Endodermal sinus tumor of the ovary.

Endodermal sinus tumor (EST) of the ovary is a germ cell tumor that is now recognized more frequently than in the past. Since problems concerning natural history, prognosis and therapy of these neoplasms are not entirely resolved, it should be underlined the need to report new cases. The authors describe four cases of EST with reference to serial alphafetoprotein determination by radioimmunoassay; they also emphasize the importance of this technique as a very sensitive method in monitoring therapy and in detecting recurrences of disease even before any clinical evidence.

Adolescent↗
PubMed1980

[Catecholaminergic neuronal pathways in homeostatic control of blood circulating mass].

Anti-thirst and anti-diuresis responses have been observed in rats with 50 mg/os of L-dopa and L-methyl-dopa. When rats are given simultaneously either Fla-63, a beta-hydroxylase inhibitory drug, or phentolamine, an alpha-adrenergic blocking agent, the anti-thirst effect is changed in an opposite way; however, the last effect is not statistically significant. These data suggest that the anti-thirst effect observed in the present study could be related to a higher amount of catecholamines synthesized and to the consequent activation of the CNS alpha-adrenergic neuronal pathways. Methyldopa, with long lasting effects, can block the thirst induced by solid food up to the 9th hour. The opposite effect determined by both inhibitory agents indicates that the dopaminergic pathways play a leading role in the thirst regulation system. Furthermore, the alpha-adrenergic pathways seem to be devoided of anti-diuretic effect, since both the above mentioned inhibitory agents do not affect it.

Adrenergic alpha-Antagonists↗
PubMed1980

[Lack of interference by carbamylcholine on the renin-angiotensin system thirst mechanism].

The thirst mechanism by carbamylcholine and the possible interactions with the renin-angiotensin system have been investigated. Rats placed in metabolic cages in order to measure the drunk water and the emitted urine were used. Carbamylcholine has been injected together with captopril, an inhibitor of the enzyme converting angiotensin I into angiotensin II, and with propranolol, which blocks the renin beta-receptors respectively. When given in combination with these substances, the thirst by carbamylcholine was not reduced; this result does not favour the hypothesis of a role of the renin-angiotensin system. On the contrary, the thirst by carbamylcholine seems to be due to a vasomotor action. These results confirm the hypothesis that an unbalance between the blood circulating mass and the venous vessels underlies the regulation of the thirst.

Angiotensin II↗