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Biomedical subjects

E D WIGLE

Publications and source records attributed to E D WIGLE.

18 recordsLinked to original sources
PubMed1965

THE NATURE OF THE DISORDER OF FUNCTION IN CHRONIC POSTINFARCTION ANEURYSM OF THE LEFT VENTRICLE.

Assessment of left ventricular function in five patients with chronic postinfarction left ventricular aneurysm was carried out at the time of left heart catheterization and compared with that in six normal subjects. One patient was investigated before and after surgical resection of the aneurysm. The presence of the aneurysm placed the left ventricle at a mechanical disadvantage in systole and increased the resistance to diastolic filling (impedance). This was true even in patients with normal cardiac indices who were not badly disabled. Resection of the aneurysm corrected both these abnormalities, and, as well, lowered the time-tension index at a time when calculated left ventricular work was much increased. These differences between normals and patients with aneurysms, and the changes occurring as a result of resection of an aneurysm, show that the presence of the aneurysm places the left ventricle at a mechanical disadvantage in systole as well as altering its diastolic filling characteristics.

Cardiac Catheterization↗
PubMed1964

HOSPITAL FACILITIES FOR THE MANAGEMENT OF ACUTE CARDIORESPIRATORY FAILURE.

A description is given of the arrangements made in a large Canadian teaching hospital for the management of acute respiratory failure and of cardiac arrest. Each ward is provided with a case containing a selection of drugs, a bag and mask for intermittent positive pressure respiration, a laryngoscope and endotracheal tubes. In such emergencies, key personnel are called on the hospital public address system as soon as the switchboard is informed of the location of the patient concerned. A resuscitation training program for medical students, interns and nurses has been instituted.

Canada↗
PubMed1963

MUSCULAR SUBAORTIC STENOSIS: THE EFFECT OF PERIPHERAL VASODILATATION.

Amyl nitrite was administered on two occasions to a patient with muscular subaortic stenosis, to ascertain if selective peripheral vasodilatation would affect the degree of obstruction to left ventricular outflow in this condition. On each occasion there was a marked increase in the systolic pressure gradient across the left ventricular outflow tract prior to the onset of reflex tachycardia. Following the second amyl nitrite inhalation, the systolic cross-sectional area of the left ventricular outflow tract decreased to 1.0 sq. cm., from the control value of 2.6 sq. cm. It is believed that the increased degree of muscular subaortic stenosis, following peripheral vasodilatation, could be secondary to a decrease in the systolic size of the whole left ventricle, or to a selective decrease in the physical size of the left ventricular outflow tract.

Amyl Nitrite↗