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Biomedical subjects

E D Pellizzari

Publications and source records attributed to E D Pellizzari.

At least 37 records · Page 2Linked to original sources

The TEAM (Total Exposure Assessment Methodology) Study: personal exposures to toxic substances in air, drinking water, and breath of 400 residents of New Jersey, North Carolina, and North Dakota.

EPA's TEAM Study has measured exposures to 20 volatile organic compounds in personal air, outdoor air, drinking water, and breath of approximately 400 residents of New Jersey, North Carolina, and North Dakota. All residents were selected by a probability sampling scheme to represent 128,000 inhabitants of Elizabeth and Bayonne, New Jersey, 131,000 residents of Greensboro, North Carolina, and 7000 residents of Devils Lake, North Dakota. Participants carried a personal monitor to collect two 12-hr air samples and gave a breath sample at the end of the day. Two consecutive 12-hr outdoor air samples were also collected on identical Tenax cartridges in the backyards of some of the participants. About 5000 samples were collected, of which 1500 were quality control samples. Ten compounds were often present in personal air and breath samples at all locations. Personal exposures were consistently higher than outdoor concentrations for these chemicals and were sometimes 10 times the outdoor concentrations. Indoor sources appeared to be responsible for much of the difference. Breath concentrations also often exceeded outdoor concentrations and correlated more strongly with personal exposures than with outdoor concentrations. Some activities (smoking, visiting dry cleaners or service stations) and occupations (chemical, paint, and plastics plants) were associated with significantly elevated exposures and breath levels for certain toxic chemicals. Homes with smokers had significantly increased benzene and styrene levels in indoor air. Residence near major point sources did not affect exposure.

Air Pollutants, Occupational↗

Recent advances in the analysis of polychlorinated biphenyls in environmental and biological media.

Analytical advances in the detection, identification and quantification of polychlorinated biphenyl isomers (PCBs) are reviewed. High-resolution gas chromatography, with specific reference to capillary column development and support "phases", methodologies, detector systems and the comparative advantages and limitations of each combination, is covered. Problems associated with instrument calibration, general non-availability of primary PCB standards and the use of secondary standards are discussed. Typical applications of these newer methods to environmental, biological and process stream samples are presented.

Aroclors↗

Breath sampling.

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Air Pollutants↗

A comparison of thermospray and direct liquid introduction high-performance liquid chromatography/mass spectrometry for the analysis of candidate antimalarials.

The analysis of antimalarials by high-performance liquid chromatography (HPLC)/mass spectrometry demonstrates a new dimension in specificity along with increased sensitivity compared to conventional HPLC detection methods. Both direct liquid introduction and thermospray HPLC/mass spectrometry interfaces provided molecular weight information as well as characteristic fragment ions for antimalarials not normally amenable to direct probe or gas chromatographic/mass spectrometric techniques. The direct liquid introduction interface, which incorporated a 1/100 split, showed a detection limit of 30 ng using selected ion monitoring. The thermospray technique showed less than 1 ng detection limits using selected ion monitoring.

Animals↗

Method for analysis of polybrominated biphenyls by gas chromatography mass spectrometry.

Gas chromatography using a short packed column (45 cm, 0.2 cm i.d., 2% OV-101 on Gas-Chrom Q) with mass spectrometric detection in the selected ion monitoring mode has been found satisfactory for the analysis of lower as well as higher polybrominated biphenyls. Acceptable sensitivity (< 1 ng) may be achieved for this method by focusing selectively at either the low (m/z 20-600) or the high m/z 600-1000) range of the quadrupole filter (low range for mono- through hexabromobiphenyl, high range for hexa- through decabromobiphenyl). A tuning technique has been developed for low range and high range polybrominated biphenyls using the ion abundances of perfluorotributylamine as a standard. Standard ions for the quantitation of mono- through decabromo-biphenyls were selected and validated. The technique was applied to the analysis of a variety of environmental samples.

Animals↗

Gas chromatography mass spectrometry computer analysis of volatile halogenated hydrocarbons in man and his environment--A multimedia environmental study.

As part of a study to make a comparative analysis of selected halogenated compounds in man and the environmental media, a quantitative gas chromatography mass spectrometric analysis of the levels of the halogenated compounds found in the breath, blood and urine of an exposed population (Old Love Canal area, Niagara, New York) and their immediate environment (air and water) was undertaken. In addition, levels of halogenated hydrocarbons in air samples taken in the general Buffalo, Niagara Falls area were determined.

Air Pollutants↗

Identification of N-nitrosodimethylamine in ambient air by capillary gas-liquid chromatography mass spectrometry computer.

Organic vapors in ambient air, at or near an industrial site in Baltimore, Maryland, were collected by adsorption on a sorbent of porous polymer (Tenax GC, 35/60). The pollutants were recovered by thermal desorption and analyzed by gas-liquid chromatography mass spectrometry computer using capillary glass SCOT columns. N-Nitrosodimethylamine was identified from its mass spectrum as a constituent of the atmosphere in the areas sampled. The identification of this compound was confirmed by comparison of its mass spectrum with that of authentic N-nitrosodimethylamine; identical retention times of unknown and authentic compound on three different capillary columns were observed.

Air Pollutants↗