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Biomedical subjects

E D Martin

Publications and source records attributed to E D Martin.

At least 37 records · Page 2Linked to original sources
PubMed1987

Histochemical study of mucosubstances in carcinoma of gastric remnant.

Twenty patients with carcinoma of the gastric remnant after surgery for benign disease have been studied. The histologic and histochemical data on gastric mucosa surrounding the carcinoma have been compared with data from 60 biopsy samples taken from gastric stumps without carcinoma in an age-and sex-matched group. There was a high incidence of intestinal metaplasia in the gastric stumps (24 of 60); it was even higher in the cases with a carcinoma (17 of 18). Intestinal metaplasia Type III, which is closely related to the carcinoma in a stomach not surgically treated, was rare in cases of cancer in the gastric stump (1 in 18). This finding is correlated to the high frequency of the diffuse type of carcinomas that occur in the gastric stump (15 of 20), which are rarely associated with intestinal metaplasia. Therefore, identifying intestinal metaplasia types does not always point to the fact that affected patients will also be at high risk for cancer in their gastric remnant.

Adenocarcinoma↗
PubMed1986

Comparative study of automated morphometric and semiquantitative estimations of alcoholic liver steatosis.

Needle biopsy of the liver is of great value in appreciating the intensity, type and topography of the steatosis commonly observed during chronic alcoholic diseases. The usual semiquantitative optical analysis is very inaccurate and depends on the subjectivity and training of the pathologist. We therefore performed an automated analysis of liver steatosis using a QTM 720 image analyzer connected to a PDP 11/34 minicomputer. Visual control of the results of the automated analysis showed it to give good results: 94% of the droplets were detected and only 10% of the patterns automatically selected were not droplets. Eight normal biopsies and 37 biopsies showing alcoholic liver steatosis were analyzed. The automated morphometric analysis calculated the mean density (percentage) of steatosis and the size distribution of the droplets. Statistical comparison of these results with those of the semiquantitative optical analysis performed independently by two pathologists showed a significant correlation between their calculations of the density/degree of steatosis but significant differences for their evaluation of the type of steatosis. The pathologists constantly overestimated the ratio of macrodroplets to microdroplets.

Biopsy, Needle↗
PubMed1981

[Technics, main advantages and best indications of quick plastic embedding (author's transl)].

Three recent progresses allow to perform plastic embedding of moderate or large samples of tissue in limits of time close to those of the paraffin embedding and to obtain slices between 1 and 2,5 mu on which all current histochemical or even histo-immunological reactions are possible. These technics prevent the retraction of the tissues, give a good preservation of the structure of the cells and permit a good analysis of the tiny lesions of all kinds of tissues. From our experience about 1362 varied biopsies, the best indications seems to be in order : kidney, hepatic, lung, medullary and nodes biopsies. It seems now justified to introduce these technics as a routine one, inside laboratories which have to detect tiny lesions on particular tissues or on experimental samples.

Animals↗
PubMed1980

Night terrors. Clinical characteristics and personality patterns.

The development and clinical course of night terrors and the personality patterns of patients with this disorder were evaluated in 40 adults who had a current complaint of night terrors. Compared with a group of adult sleepwalkers, the patients with night terrors had a later age of onset for their disorder, a higher frequency of events, and an earlier time of night for the occurrence of episodes. Both groups had high levels of psychopathology, with higher values for the night terror group. This sleepwalkers showed active, outwardly directed behavioral patterns, whereas the night terror patients showed an inhibition of outward expressions of aggression and a predominance of anxiety, depression, tendencies obsessive-compulsive/, and phobicness. Although night terrors and sleepwalking in childhood seem to be related primarily to genetic and developmental factors, their persistence and especially their onset in adulthood are found to be related more to psychological factors.

Adolescent↗