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Biomedical subjects

E D Jacobson

Publications and source records attributed to E D Jacobson.

At least 91 records · Page 5Linked to original sources
PubMed1980

Superior mesenteric angiography and blood flow measurement following intra-arterial injection of prostaglandin E1.

The hemodynamic effects of intra-material prostaglandin E1 (PE1) administered via the angiographic catheter were evaluated in 14 patients. Blood flow in the superior mesenteric artery (SMA) after PGE1 infusion was compared with control SMA blood flow as measured by the "spillover" angiographic reflux method, using a specially designed injector/film-changer system. In all patients, SMA blood flow increased by more than 50% and visualization of the SMA and portal vein was enhanced.

Adult↗
PubMed1979

Peripheral vascular H2 receptors to histamine.

The development of two different types of antagonists to the many actions of histamine has permitted exploration of vascular receptors to the amine. Certain cautions are necessary to avoid inaccurate conclusions in such studies, however. From available literature it appears that both H1 and H2 receptors to histamine are widely distributed in the circulation. In a given regional vasculature discrete actions of each receptor may be evident.

Animals↗
PubMed1979

Effects of vasodilators on mesenteric ischemia and hypoxia induced by hemorrhage.

We compared the effectiveness of three pharmacologically and chemically dissimilar vasodilators (histamine, glucagon, and perhexiline) in reversing the hemodynamic and metabolic deficits of intestinal ischemia produced by hemorrhage. With intraarterial infusion into the superior mesenteric artery of anesthetized control dogs, all three agents increased mesenteric blood flow and oxygen consumption without altering systemic arterial blood pressure. Similarly, in the ischemic gut following moderate hemorrhage all three vasodilators increased mesenteric flow and oxygen consumption while reducing vascular resistance and not affecting systemic arterial blood pressure. On a molar basis glucagon was the most potent dilator drug. In severely hemorrhaged dogs whose intestinal blood flow had been reduced nearly 80%, glucagon restored oxygen uptake and vascular resistance to control levels. These findings demonstrate the efficacy of three different vasodilators in reversing the mesenteric ischemia and hypoxia produced by hemorrhage.

Animals↗
PubMed1979

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Faculty, Medical↗