Biomedical subjects

E D Endean

Publications and source records attributed to E D Endean.

At least 19 recordsLinked to original sources

PubMed2002

A review of telemedicine in vascular surgery.

Telemedicine refers to the delivery of medical care through telecommunications and has been utilized by many medical specialists. In its basic form, telemedicine can involve the use of a telephone or fax. More advanced forms are the transmission of still images, often referred to as "store-and-forward" technology, or real-time two-way interactive video. The former is possible over existing phone lines or the Internet and has enjoyed success in visually oriented disciplines such as radiology and dermatology. The latter requires high bandwidth communication lines and is therefore considerably more expensive. This article reviews the use of telemedicine as applied specifically to vascular surgery. Initial studies indicate that store-and-forward technology can be used to adequately assess and treat wounds in vascular patients. A recent study reported the use of two-way interactive video for remote assessment of a wide variety of vascular patients. Diagnosis and treatment recommendations by the remote physician were found to be comparable to conventional on-site examinations. Patient satisfaction with the telemedicine examination was noted to be extremely high. In conclusion, telemedicine, although not commonly used in vascular surgery, has the potential of increasing patient access to specialty care, while decreasing patient or physician travel. The use of telemedicine in vascular surgery will likely continue to expand as technology improves and costs decrease.

Cost-Benefit Analysis↗

PubMed2001

Enoxaparin treatment in high-risk trauma patients limits the utility of surveillance venous duplex scanning.

OBJECTIVE: The value of surveillance venous duplex scanning for detecting unsuspected deep venous thrombosis (DVT) in trauma patients who are receiving enoxaparin prophylaxis is open to question. This study was undertaken to determine whether enoxaparin reduced the clinical utility of surveillance scanning and whether management of these patients was altered by findings of the scans. METHODS: The medical records of trauma patients who met defined criteria for high DVT risk, admitted during 30 consecutive months, were reviewed. These patients received enoxaparin 30 mg every 12 hours for the duration of their admissions. Per protocol, surveillance lower extremity venous duplex scans were performed within 72 hours of enoxaparin administration and then weekly until patients were discharged from the hospital. The records were reviewed for thromboembolic events (DVT or pulmonary embolism [PE]), patient location and ambulatory status, therapeutic interventions (systemic anticoagulation, vena cava filter), and complications of enoxaparin therapy. RESULTS: A total 241 patients underwent 513 venous duplex examinations (1-13 per patient). Eight patients had DVT on the initial scan; seven of these patients were asymptomatic. Five were treated with anticoagulation and/or vena cava filter placement. Of the 233 patients with initially negative duplex scan results, five patients (2%) developed clinically unsuspected lower extremity DVT while hospitalized. All of these five patients were in an intensive care unit. Three of the five patients had no change in treatment. Two of the five underwent anticoagulation, and one vena cava filter was placed. PE occurred in two hospitalized patients, one of whom was ambulatory, with negative duplex scan results. After hospital discharge, six other patients had symptomatic DVT or PE despite in-hospital scans with negative results. Complications associated with enoxaparin included hemorrhage (2) and thrombocytopenia (8). CONCLUSIONS: After initial negative scan results, repeat surveillance duplex scanning during hospitalization detected a low incidence (2%) of DVT in high-risk patients. Furthermore, the detection of unsuspected DVT altered the clinical management of less than 1% of the patients tested. Thus, after a venous duplex scan with negative results and initiation of enoxaparin prophylaxis, subsequent surveillance duplex examinations are not warranted in asymptomatic trauma patients.

Adolescent↗

PubMed2001

Surgical management of thrombotic acute intestinal ischemia.

OBJECTIVE: To evaluate the University of Kentucky experience in treating acute intestinal ischemia to elucidate factors that contribute to survival. SUMMARY BACKGROUND DATA: Acute intestinal ischemia is reported to have a poor prognosis, with survival rates ranging from 0% to 40%. This is based on several reports, most of which were published more than a decade ago. Remarkably, there is a paucity of recent studies that report on current outcome for acute mesenteric ischemia. METHODS: A comparative retrospective analysis was performed on patients who were diagnosed with acute intestinal ischemia between May 1993 and July 2000. Patients were divided into two cohorts: nonthrombotic and thrombotic causes. The latter cohort was subdivided into three etiologic subsets: arterial embolism, arterial thrombosis, and venous thrombosis. Patient demographics, clinical characteristics, risk factors, surgical procedures, and survival were analyzed. Survival was compared with a collated historical series. RESULTS: Acute intestinal ischemia was diagnosed in 170 patients. The etiologies were nonthrombotic (102/170, 60%), thrombotic (58/170, 34%), or indeterminate (10/170, 6%). In the thrombotic cohort, arterial embolism accounted for 38% (22/58) of the cases, arterial thrombosis for 36% (21/58), and venous thrombosis for 26% (15/58). Patients with venous thrombosis were younger. Venous thrombosis was observed more often in men; arterial thrombosis was more frequent in women. The survival rate was 87% in the venous thrombosis group versus 41% and 38% for arterial embolism and thrombosis, respectively. Compared with the collated historical series, the survival rate was 52% versus 25%. CONCLUSIONS: These results indicate that the prognosis for patients with acute intestinal ischemia is substantially better than previously reported.

Age Factors↗

PubMed2001

Telemedicine in vascular surgery: does it work?

Telemedicine (TM) using closed-circuit television systems allows specialists to evaluate patients at remote sites. Because an integral part of the vascular examination involves palpation of peripheral pulses the applicability of TM for the evaluation of vascular surgery patients is open to question. This study was carried out to test the hypothesis that TM is as effective as direct patient examination for the development of a care plan in vascular patients. Sixty-four vascular evaluations were done in 32 patients. The patients presented with a variety of vascular problems and were seen in regularly scheduled rural outreach vascular clinics. Two faculty vascular surgeons evaluated each patient; one was on site and the second, using TM, remained at the medical center. Each surgeon was blinded to the other's findings. The TM physician was aided by a nonphysician assistant, who obtained blood pressures, utilized a continuous-wave Doppler probe, positioned the patient, and operated the TM equipment. The results of each surgeon's evaluations were compared. Patient and physician satisfaction with the TM evaluation was appraised by questionnaires. Eight patients were seen for initial evaluations; 24 patients were seen for follow-up visits. Patients were seen with a variety of diagnoses, including aneurysm (seven), cerebrovascular disease (five), lower extremity occlusive disease (13), multiple vascular problems (three), and other disease (four). The average duration for the TM and on-site evaluations were 20.6+/-1.4 and 19.0+/-1.3 minutes, respectively (P = not significant). Physician concordance, as determined by treatment recommendations, was the same in 29 (91%) patients. Physician confidence in the ability to obtain an accurate history via TM was rated as excellent in 97 per cent; confidence in the TM physical examination was rated as excellent in 70 per cent. All patients rated the TM evaluation as the "same as" or "better than" the on-site examination, and all indicated a preference for being seen locally using TM as opposed to traveling to a regional medical center. We conclude that the TM evaluation of vascular patients is accurate and is as effective as on-site evaluations for a variety of vascular problems. Important adjuncts to enhance the success of a TM evaluation are physician experience with the technology and the presence of a knowledgeable on-site assistant. This technology can be easily adapted to other clinical situations.

Academic Medical Centers↗

PubMed1998

Process improvements reduce utilization of resources for aortic aneurysm repair.

In conjunction with the VA reorganization to promote greater efficiency of health care provision, ambulatory surgery (AS) programs have been created. These programs institute outpatient preoperative assessment and operative management. This study examines the impact of these process changes on resources utilized by patients requiring repair of abdominal aortic aneurysms (AAAs). The medical records of 15 consecutively treated patients undergoing elective, infrarenal AAA repair before (1992-1993) and after (1995-1996) AS implementation were reviewed. Resource utilization was assessed by evaluating preoperative tests performed (inpatient or outpatient), ICU days, and inpatient length of stay (LOS). Postoperative morbidity and mortality were noted. Patient age, AAA size, and prevalence of diabetes mellitus, hypertension, cardiac disease, COPD, and tobacco use were similar between the two groups. Abdominal ultrasound, CT scanning, and angiography were significantly more frequently performed on an outpatient basis after implementation of the AS program. The median preoperative LOS was reduced in the AS group (1 vs 6 days, P = 0.001, Student t test), resulting in a lower inpatient LOS (11 vs 16, P < 0.01, Student t test). All patients survived and the incidence of complications was similar between the groups. Hospital resource utilization was significantly decreased, largely by shifting preoperative assessment to the outpatient setting. This study illustrates that benefits of an ambulatory surgery program can be extended beyond facilitating outpatient operations and should result in decreased length of hospitalization for other major surgical procedures, such as abdominal aortic aneurysm repair.

Aged↗

PubMed1998

Nontraumatic lower-extremity acute arterial ischemia.

BACKGROUND: The outcome of arterial bypass reconstruction in the setting of acute arterial ischemia has not been well defined. METHODS: This retrospective review consists of 71 consecutive patients (54 with native arterial thrombosis, 17 with graft thrombosis) who underwent an urgent/emergent arterial bypass reconstruction for acute arterial ischemia with threatened limb viability. RESULTS: The 30-day mortality and major amputation rates were 9.9% and 7.1%, respectively. Death, limb loss, or both, were associated with a paralytic limb (P = 0.001) and congestive heart failure (P = 0.03). Overall, 45 of 71 (63%) patients were discharged with limb salvage and ambulatory function. Cumulative graft patency was 77% and 65% at 1 and 2 years, respectively, and closely approximated the 1- and 2-year limb-salvage rates of 76% and 63%, respectively. CONCLUSIONS: Arterial bypass reconstructions appear warranted in acute arterial ischemia, in that a majority of patients retain a functional viable limb. Late graft thrombotic complications limit long-term benefit.

Acute Disease↗

PubMed1998

Popliteal artery thrombosis associated with trampoline injuries and anterior knee dislocations in children.

Recent reports have emphasized the benign nature of trampoline-associated injuries. However, this study describes the limb-threatening problem of popliteal artery thrombosis occurring in association with anterior knee dislocation and trampoline injuries. Three children (ages 11, 13, and 17) were referred to the emergency room within the past 12 months with anterior dislocations of the knee, which occurred while jumping on trampolines. All patients had reduction of their dislocations at outside facilities and were referred within 6 to 12 hours after their injuries, with pulse, motor, and sensory deficits. All patients were taken directly to the operating room, where arteriography confirmed thrombosis of the popliteal artery below the knee. One patient had transection of the artery, whereas two patients had stretch injuries with intimal separation. Each patient required interposition grafting with reversed saphenous vein and underwent concomitant four-compartment fasciotomy. All patients had persistent sensory and motor deficits postoperatively, which were presumed to be a combination of ischemic injury and neuropraxia. All patients have functioning grafts with an average follow-up of 1 year (range, 9-15 months). One patient required a second interposition graft to treat an area of intimal hyperplasia, which developed at the proximal anastomosis, at 6 months postoperatively. Eighty per cent of trampoline injuries are associated with minor injuries with minimal long-term complications. However, dislocations of the knee may be associated with significant arterial injury and amputation rates of up to 30 per cent in many blunt trauma series. Based on our experience, physicians should recognize the possibility of significant arterial injuries occurring in children with anterior knee dislocations while jumping on trampolines.

Adolescent↗

PubMed1997

Intra-arterial urokinase versus surgery for acute peripheral arterial occlusion.

The outcomes of intra-arterial urokinase versus surgery for acute peripheral arterial occlusion (PAO) were compared. Patients at a university hospital who had received intraarterial urokinase for PAO were identified by computer and pair-matched on the basis of comorbidities, age, sex, and site of occlusion to computer-selected patients who had undergone surgery. Only patients with category I or II ischemia were considered. The study period for the urokinase group was February 1995 through January 1996, and the period for the surgery group was June 1993 through January 1996. Twenty-eight patients in each group met the selection criteria. Patients who had received urokinase had a significantly shorter median length of stay (8.5 days) than patients in the surgery group (13 days) and significantly fewer infectious complications (2 versus 10). No differences in amputation rates, total hospital costs, or mortality rates were detected. Patients who received intra-arterial urokinase for PAO had a shorter length of stay in the hospital and fewer infectious complications than those who underwent surgery.

Adult↗

PubMed1995

An angioscopic method for intraluminal aortic evaluation and stent placement.

PURPOSE: The purpose of this study was to develop an angioscopic technique to visualize the endoluminal surface of the aorta and to guide vascular stent placement. METHODS: A fiberoptic angioscope, fitted with a balloon at its tip, was passed via a carotid arteriotomy into the abdominal aorta of seven anesthetized pigs. Saline solution inflation of the balloon allowed for blood displacement and clear visualization of the endoluminal anatomy. After the left renal artery orifice had been identified with angioscopy, a catheter was inserted via a left femoral sheath to cannulate the orifice under direct visualization. The position of the catheter was verified angiographically. A vascular stent was loaded onto an angioplasty balloon, inserted through a right femoral arteriotomy, positioned by use of angioscopic visualization, and deployed immediately below the left renal artery orifice. RESULTS: The aortic trifurcation and the lumbar and renal artery orifices were clearly visualized in every animal. Vascular stents were placed in seven animals within an average of 3.14 +/- 1.14 mm (mean +/- SEM, range 0 to 8 mm) below the inferior rim of the left renal artery orifice. No stents were positioned above a renal artery orifice or obstructed blood flow. CONCLUSIONS: This angioscopic technique permitted detailed evaluation of aortic endoluminal anatomy and precise implantation of vascular stents. Direct endovascular visualization may facilitate other endovascular procedures, including endovascular grafting.

Angioscopy↗

PubMed1995

Carotid artery occlusion after dog bite.

The etiology of most penetrating neck injuries is caused by missiles or stabbings. Irrespective of the cause of injury, management strategies require that life-threatening injuries to underlying deep neck structures such as esophagus, trachea, or carotid artery be promptly identified. A case is reported in which occlusion of the common carotid artery resulted from a dog bite to the neck. The patient presented to the emergency department with four neck lacerations but lacked focal neurologic symptoms suggestive of such an underlying deep neck injury. The carotid injury was identified by preoperative angiography and was repaired with a reversed saphenous vein interposition graft. The patient had full recovery without neurologic sequela. While injuries to deep neck structures as a result of animal bites are rare, these patients should be evaluated according to accepted protocols to exclude or identify such life-threatening injuries.

Adult↗

PubMed1994

Characterization of polyamine transport in rat aortic smooth muscle cells.

Increased arterial wall polyamine content has been linked to intimal hyperplasia (IH) formation. Intracellular polyamine content may be regulated by a polyamine transmembrane transport mechanism, but the existence of such a system has not been demonstrated in systemic arterial smooth muscle cells. This study characterizes polyamine transport as found in rat aortic smooth muscle cells. Smooth muscle cells were isolated and cultured from Sprague-Dawley rat aortas. Polyamine transport was determined by adding [14C]-polyamines to the medium, calculating transport kinetic parameters, Vmax and Km. Competition studies with unlabeled polyamines and uptake in the presence of paraquat, a polyamine transport inhibitor, were done to test the specificity of the uptake system. We identified polyamine transporters in aortic smooth muscle cells which were temperature, concentration, and time dependent. Kinetic studies revealed that spermidine and spermine had greater affinity for the transporter(s) than putrescine (Km = 0.3, 0.3, and 3.7 microM respectively; P = 0.0001) while maximum uptake velocity was similar for all polyamines (26.6-31.0 pmole/mg protein/min). Inhibition of de novo polyamine synthesis upregulated polyamine transport 2.8-3.8 times (P = 0.0001) while transporter affinity (as reflected by Km) remained unchanged. Competition studies and paraquat treatment indicated the presence of two polyamine transporters: one shared by all polyamines, the other specific for spermine and spermidine. These data indicate that transmembrane polyamine transport occurs in arterial smooth muscle cells. Upregulation of this system may represent one control mechanism for IH development.

Animals↗

PubMed1994

Morphology predicts rapid growth of small abdominal aortic aneurysms.

This study evaluated CT scans of small abdominal aortic aneurysms (AAAs) (< 5 cm) to assess anatomic features associated with rapid expansion. Serial CT scans obtained at least 10 months apart (mean 15 months) from patients with small AAAs were reviewed. Each cross-sectional image of the AAAs was analyzed using a computer-assisted design program. The circumference of the AAA in each CT image was divided into eight equal arcs, from which the apparent radius of curvature (Rc) for each segment was calculated. Flattening of the wall curvature results in an increased segmental Rc. The CT scans of nine patients with expanding AAAs (expansion > or = 0.5 cm/yr) were compared to those of 10 patients with stable AAAs (expansion < or = 0.2 cm/yr). To adjust for differences in AAA size, the Rc for each segment was normalized by dividing each individual Rc by the average of the eight Rcs (RcAvg) calculated for that cross-sectional CT image. Analysis of variance showed that the left posterolateral segments in expanding AAAs had larger Rc/RcAvg ratios than those segments in stable AAAs (1.14 +/- 0.19 vs. 0.80 +/- 0.09, p < 0.02). Laplace's law indicates that the left posterolateral segment in AAAs that grow more rapidly is subjected to greater wall tension. Flattening in the curvature of the left posterolateral wall segment was significantly associated with an increased rate of expansion in small AAAs. This finding, readily derived from standard CT scan images, may predict which small AAAs are more prone to rapid expansion.

Aortic Aneurysm, Abdominal↗

PubMed1994

Performance of the vascular physical examination by residents and medical students.

PURPOSE: This study uses an objective structured clinical examination to evaluate the performance and interpretation of the vascular physical examination by interns and medical students. METHODS: A patient with lower extremity arterial occlusive disease findings was examined by 20 third-year students (M3), 23 physicians entering surgical internship (PGY1), and 7 individuals completing internship (PGY2). The test consisted of two sections: part A evaluated the individuals' ability to perform a pulse examination (data gathering); part B evaluated the interpretation of the physical examination findings (data interpretation). National Board of Medical Examiners Part II examination results were obtained for 84% of participants. RESULTS: All groups performed poorly, with overall correct percent scores being 43% (M3), 39% (PGY1), and 62% (PGY2). PGY2s performed significantly better than M3s or PGY1s (p = 0.0002). No statistical difference was noted between M3 and PGY1 scores. Overall, data gathering skills were significantly better than data interpretation skills (51% vs 37%, p = 0.0001). National Board of Medical Examiners Part II scores did not vary substantially among groups. CONCLUSIONS: Interns and medical students demonstrated considerable inaccuracy in both data gathering and data interpretation. A modest improvement was observed in individuals tested at the end of the internship year. This study suggests that increased attention should be directed toward instructing surgical residents and students how to perform an accurate peripheral vascular physical examination and how to interpret its significance.

Arterial Occlusive Diseases↗

PubMed1993

Thromboembolic complications of polycythemia: polycythemia vera versus smokers' polycythemia.

PURPOSE: This report compares patients with the hypercoagulable state of polycythemia vera to patients with secondary polycythemia caused by tobacco use to determine whether the incidence of thromboembolic events is equivalent. METHODS: The medical records of 146 patients with the diagnosis of polycythemia between 1977 to 1990 were reviewed. Patients with transient, relative, or stress polycythemia were excluded from this study as were patients with polycythemia as a result of cardiac or pulmonary anomalies or both. The diagnosis of polycythemia vera (n = 43) was verified by use of the guidelines of the Polycythemia Vera Study Group. The diagnosis of polycythemia caused by smoking (n = 27) was based on an elevated total red blood cell volume, decreased oxygen saturation on arterial blood gas measurement, evidence of chronic obstructive pulmonary disease, and elevated carboxyhemoglobin levels. RESULTS: Twenty-six patients (60%) with polycythemia vera and 11 patients (41%) with smoker's polycythemia had at least one thromboembolic problem. No significant differences existed between the groups with regard to age, hematocrit, or number of cardiac and cerebrovascular events. Overall, patients with polycythemia vera had a greater number of thromboembolic events per patient (p < 0.05) and more peripheral arterial thromboemboli (p < 0.005) than did patients with polycythemia as a result of smoking (Fisher's Exact Test). CONCLUSIONS: Thus the results of this study demonstrate that smokers' polycythemia does not represent a hypercoagulable state equivalent to that of polycythemia vera.

Analysis of Variance↗

PubMed1992

Recognition of arterial injury in elbow dislocation.

The clinical presentation of patients with elbow dislocations was reviewed to identify those factors indicating an increased risk for arterial injury. Sixty-two patients were treated for 63 elbow dislocations between January 1981 and July 1991. Eight patients (13%) sustained a concomitant arterial injury involving the brachial (7) and radial (1) arteries. Three clinical findings, absence of a radial pulse, open dislocation, and presence of systemic injuries, were correlated with arterial injury. A palpable radial pulse was absent in six (75%) patients with an arterial injury but in only two (4%) with normal vessels (p less than 0.0001, chi square). Five (33%) open dislocations had an associated arterial injury, whereas three (6%) arterial injuries occurred in closed dislocations (p less than 0.006, chi square). Systemic injury occurred in five dislocations (63%) with arterial injuries and 14 dislocations (25%) without arterial injury (p less than 0.04, chi square). Multivariate analysis showed that absence of a radial pulse was the only factor that significantly predicted arterial injury (p less than 0.0001). Although most elbow dislocations are not associated with arterial injury, absence of a radial pulse or presence of an open dislocation or both should alert the clinician to the increased possibility of an associated vascular injury.

Adult↗

PubMed1991

Intimal hyperplasia is reduced by ornithine decarboxylase inhibition.

Polyamines are intracellular cations that are thought to play a role in the regulation of cell growth and differentiation. This study was undertaken to determine if inhibition of ornithine decarboxylase (ODC), the rate-limiting enzyme of polyamine synthesis, suppresses formation of intimal hyperplasia (IH) after arterial injury. Twenty New Zealand white rabbits underwent balloon catheter deendothelialization of a common carotid artery. Treated animals (n = 10) were given alpha-difluoromethylornithine (DFMO), an inhibitor of ODC, ad lib in drinking water as a 2% solution. DFMO was begun 3 days prior to surgery and continued until vessel harvest. Vessels were perfusion-fixed at harvest, 2 (n = 10) and 4 (n = 10) weeks postoperatively. All arteries remained patent. There were no histologic differences in the IH between treated and untreated animals. The intima and media surface areas on serial arterial cross sections were determined using computer-assisted planimetry. There was a significant difference in the IH surface area of injured arteries between untreated and DFMO-treated animals at both 2 (17.6 +/- 2.0 vs 3.0 +/- 1.6 microns 2; P less than or equal to 0.001) and 4 weeks 27.4 +/- 5.6 vs 7.1 +/- 1.8 microns 2; P less than or equal to 0.008). No differences were seen in medial thickness. We conclude that ODC inhibition reduces early development of IH after arterial deendothelialization. These data support the hypothesis that polyamines may be cellular messengers involved in the regulation of IH formation.

Animals↗

PubMed1991

Effects of hypercholesterolemia on healing of vascular grafts.

Small-diameter vascular grafts woven from bioresorbable lactide/glycolide copolymers have been successfully interposed into aortas of normal NZW rabbits. The current study examines the histologic and functional reactions to these bioresorbable grafts in severely hypercholesterolemic rabbits, a standard animal model of atherosclerosis. Sixty rabbits were placed on a 2% cholesterol, 6% peanut oil atherogenic diet. Baseline serum cholesterols and triglycerides were measured and repeated at operation 3 months later. Woven polyglactin 910 (PG910) grafts were interposed into infrarenal aortas. Fifty-two rabbits died on the diet or within 3 days of surgery and eight survived operation (normal NZW rabbit operative mortality is less than 10%). Cholesterol levels rose from 63 to 1989, p less than .001. Of the eight survivors, five died after 3 weeks, and one died after 2 1/2 months. Two were sacrificed at 2 and 4 months. Four aortic disruptions with retroperitoneal hematomas, one pseudoaneurysm, and one diffuse aneurysm were observed, greater than in normal rabbits, p less than .001. Inspection revealed severe atherosclerosis. Histologically, 3-week explants showed only small areas of neointima with myofibroblasts and endothelial cells; the outer capsules were infiltrated by lipid-laden macrophages. Graft material in 2- to 4-month explants was replaced by tissue with histologic atherosclerosis. More severe atherosclerosis was observed in native aortas at the perianastomotic areas than the more distant aortic segments. Abundant intracellular lipid was seen also in splenic histiocytes and hepatic cells with evidence of micronodular cirrhosis. Macrophages phagocytizing bioresorbable prostheses may release growth factors mediating the formation of a cellular tissue conduit. Severe hypercholesterolemia may alter monokine release from macrophages resulting in a weakened prosthesis/tissue complex.

Animals↗

PubMed1991

Thallium redistribution does not predict perioperative cardiac complications following vascular surgery.

Utility of preoperative stress thallium scintigraphy (STS) was determined in 59 patients, thought to be at increased risk, prior to major vascular surgery from July 1987 to February 1990. Forty-seven had oral dipyridamole and 12 underwent exercise STS. Thallium redistribution (TR) was present in 61% (n = 36); fixed defects were present in 59% (n = 35); and some combination of defects was present in 76% (n = 45). Perioperative cardiac complications (CC = congestive heart failure [n = 3], ventricular arrhythmia [n = 2], and MI [n = 1]) were present in 8.5% (6 CC in 5 patients). Incidence of CC was 8.3% (3/36) in those with TR, and 8.7% (2/23) without TR (relative risk = 0.95). Perioperative MI was present in 2.8% (1/36) with TR vs. 0% (0/23) without. Though mortality was 3.4%, no perioperative deaths were from cardiac disease. Utility of STS is not clearly established for prediction of perioperative cardiac risk after major vascular surgery.

Adult↗