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Biomedical subjects

E Czarnecka

Publications and source records attributed to E Czarnecka.

49 records · Page 3Linked to original sources
PubMedDate not supplied

Influence of combined administration of ethyl alcohol with caffeine and hydroxyzine on cardiac minute volume and stroke volume in rabbits.

The effect of combined administration of ethyl alcohol with caffeine and hydroxyzine on cardiac volume and vascular resistance was studied. Combined administration of these compounds diminished cardiac stroke volume and minute output and increased general vascular resistance. Simultaneous administration of ethanol with caffeine and hydroxyzine exerts an unfavorable effect on haemodynamics of circulatory system.

Animals↗
PubMedDate not supplied

The effect of doxepin on the central action of ethanol.

The effect of combined treatment with doxepin and ethanol was tested in mice, rats and rabbits. Doxepin was given in a single dose (5 or 10 mg/kg) or chronically (10 mg/kg/d for 21 days). Doxepin did not affect ethanol toxicity and ethanol-induced impairment of rota-rod performance, but potentiated ethanol-induced hypothermia (only acutely) and prolonged ethanol-induced sleep in mice. Given acutely it potentiated the inhibitory effect of ethanol on locomotor activity in mice, while given chronically it counteracted the ethanol-induced sedation. Doxepin did not interfere with ethanol-induced EEG effects in rabbits, and prevented the development of tolerance to hypothermic, but not to hypnotic effects of ethanol in rats. In general, the interference of doxepin with ethanol was more pronounced after single doses of the drug than after chronic treatment.

Animals↗
PubMedDate not supplied

Interaction between central effects of ethanol and tricyclic antidepressants, imipramine and amitriptyline in mice and rats.

The effect of a combined treatment with ethanol and imipramine or amitriptyline was tested in mice and rats. The antidepressants were given in one or, in some experiments, in 21 daily doses of 10 mg/kg each. In mice the effect of antidepressants was tested on acute toxicity, disturbances of rota-rod performance, hypothermia and sleeping induced by ethanol, in rats the effect of the antidepressants on the development of tolerance to sleep-inducing and hypothermic action of ethanol was investigated. Amitriptyline showed a tendency to pontentiate the ethanol-induced acute toxicity, while imipramine did not change it. Given in a single dose the antidepressants have a tendency to potentiate the impairment of motor coordination induced by ethanol, but after a prolonged administration did not influence the ethanol effect in the rota-rod test. The antidepressants enhance ethanol-induced hypothermia and prolong the ethanol sleeping time. The development of tolerance to hypnotic effect of ethanol in rats is not affected by amitriptyline and imipramine, but the antidepressants prevent the development of tolerance to hypothermic effect.

Amitriptyline↗
PubMedDate not supplied

The effect of combined treatment with ethanol and imipramine or amitriptyline on rabbit EEG.

The effect of combination of imipramine or amitriptyline acute or chronic treatment with ethanol on EEG was studied in rabbits with electrodes chronically implanted into the frontal cortex, dorsal hippocampus and midbrain reticular formation. In addition, to study the effect of the treatment on development of tolerance to ethanol, a group of rabbits receiving ethanol with antidepressants was additionally injected iv with ethanol once a week. Single doses of both the antidepressants did not alter the effect of acute administration of ethanol on EEG, but imipramine and amitriptyline potentiated the ethanol-induced changes in the EEG recorded from the midbrain reticular formation in rabbits receiving ethanol chronically and in the period of abstinene. The antidepressants did not change the development of tolerance to ethanol.

Amitriptyline↗
PubMedDate not supplied

Investigations of central interaction of ethanol and clonidine.

The combined effect of ethanol and clonidine on rabbit EEG, and the effect of clonidine on ethanol sleep in mice, as well as on acute ethanol toxicity were investigated. Moreover, the effect of clonidine on ethanol level in rabbit blood and in mouse brain and the combined effect of ethanol and clonidine on rabbit arterial blood pressure were evaluated. It has been found that clonidine intensifies the effect of ethanol in EEG and prolongs ethanol sleep. Clonidine does not change acute ethanol toxicity and does not affect ethanol level in blood and the brain. Ethanol prevents the decrease of arterial blood pressure after an intravenous or intracerebroventricular administration of clonidine.

Animals↗
PubMedDate not supplied

The effect of piracetam on the central action of ethanol in mice and rabbits.

The effect of combined single administration of ethanol and piracetam on the rabbit EEG and on locomotor activity and ethanol sleep in mice was investigated. In addition, the effect of prolonged administration of piracetam together with ethanol on rabbit EEG and after-discharges evoked by electrical stimulation of the hippocampus was studied. The blood ethanol concentrations were also monitored. Single administration of piracetam did not change the effects of ethanol, while when given prolongly with ethanol piracetam attenuated the effects of ethanol. Piracetam did not affect the ethanol blood level.

Animals↗
PubMedDate not supplied

The influence of calcium channel blockers on the central action of clonidine.

The influence of verapamil, nifedipine and cinnarizine on clonidine-induced hypothermia, spontaneous and explorative motility was investigated in mice. Verapamil 5 and 15 mg/kg, nifedipine 17.5 and 50 mg/kg and cinnarizine 75 and 200 mg/kg (that is 1/30 and 1/10 of LD50 respectively) were injected intraperitoneally. The drugs were given in single doses (1/10 LD50) and in repeated doses (1/30 LD50) during a 10 days course. In acute experiments the drugs were given 60 min before clonidine administration, while in chronic experiments clonidine was given on the 11th day of the experiment. Nifedipine prevents clonidine-induced hypothermia in both the applied doses, verapamil only in a single dose, and cinnarizine in repeated doses. Only repeated administration of nifedipine and cinnarizine weakens the clonidine-induced sedation in the studies of spontaneous motility, and as for nifedipine also in explorative motility.

Analysis of Variance↗
PubMedDate not supplied

The effect of propranolol-administration on the electroencephalogram in the rabbit.

The effect of propranolol-administration on the electroencephalogram in the rabbit. Acta Physiol. Pol., 1977, 28 (1): 45-50. The influence of propranolol on EEG of the rabbits, with electrodes chronically implanted into different brain structures, was studied. Propranolol in the doses of 1, 2 and 3 mg/kg was injected intravenously. The bioelectrical brain activity of the rabbits was measured several times after the drug injection. In the next period of experiments propranolol (2 mg/kg i.v.) was administered every day for 10 days. Moreover the influence of the same doses of this drug on ECG and arterial pressure was studied. It was found that propranolol-administration changes the bioelectrical activity of the brain. Such phenomenon as, voltage increase, irregular and slower rhythm, an increase in slow activity and spikes, fast activity was perceived. The changes in EEG were particularly well pronounced in subcortical structures. The described effects of propranolol do not depend on the influence of this drug on the circulatory system.

Animals↗
PubMedDate not supplied

Effect of nifedipine and verapamil on hypotensive action of clonidine in rabbits.

The present study examined the influence of nifedipine and verapamil on clonidine-induced hypotension in the rabbits. Clonidine was given intravenously (i.v.) (0.2 mg/kg) or intracerebroventricularly (icv) (0.03 mg). Nifedipine (0.3 mg/kg and 0.45 mg/kg) and verapamil (0.2 mg/kg and 0.3 mg/kg) were injected i.v. 15 min before clonidine administration or icv (nifedipine 0.03 mg, verapamil 0.1 mg) 10 min before clonidine. It has been shown that nifedipine administered i.v. increases whereas injected icv prevents the hypotensive action of clonidine administered in the same way. Verapamil injected i.v. and icv did not change the hypotensive action of clonidine. It seems that nifedipine has alpha 2-adrenoceptor blocking properties.

Animals↗