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Biomedical subjects

E Cuny

Publications and source records attributed to E Cuny.

26 records · Page 2Linked to original sources
PubMed1998

[Primary central nervous system lymphomas. Diagnostic and prognostic effect of steroid-induced remission].

PURPOSE: Non-AIDS primary central nervous system lymphomas may respond totally or partially to corticosteroids. These corticoid-induced remissions seems to be very specific for this disease. They have been proposed as diagnostic test. The effect of these remissions on prognosis remains unknown. METHODS: A retrospective study was conducted. Corticosteroid sensibility, duration of survival, duration of disease free interval and type of treatment were compared between two groups of patients. The first one (group 1) included 44 patients in which exact diagnosis was made by stereotactic biopsy or surgery. The second group (group 2) included 5 patients exhibiting typical neuroradiological aspects of primary lymphoma in whom corticosteroid therapy produced a total regression of the lesions. RESULTS: In group 1, 29.1% of the lymphomas exhibited cortico-sensitivity. Duration of free interval of disease accounted for 75% of the overall duration of survival. Age was the only significant factor predicting remission (p = 0.019). The sole factor influencing total duration of remission was the type of treatment (p = 0.03). Duration of remission was significantly shorter in group 2 versus group 1 patients (p = 0.007). CONCLUSIONS: Duration of the first remission is of paramount importance on survival as well as the quality of first line therapy. In these conditions the absence of precise diagnosis due to corticoid-induced remissions could be dramatically deleterious.

Adrenal Cortex Hormones↗
PubMed1998

[Peripheral neurotomy in the treatment of spasticity. Indications, techniques and results in the lower limbs].

INTRODUCTION: The aim of this study was to review the principle of peripheral neurotomy for the treatment of lower limb spasticity. The importance of clinical assessment is stressed (with particular focus on motor block) for determining the best surgical indications. MATERIAL AND METHOD: Between 1989 and 1997, 392 neurotomies were performed in 277 patients in the neurosurgery department of the Henri Mondor Hospital, Créteil, France. Surgical technique consisted in partial and segmental resection, involving each motor collateral branch of muscles with excessive spasticity. For the lower limb, the most frequent neurotomy was performed on collateral branches of the posterior tibial nerve (66%) for the spastic foot. RESULTS: Preoperative motor block provided the advantage of "mimicking" the effect of the neurotomy and therefore gave the patients an idea of the expected result of surgery. For the spastic foot, posterior neurotomy led to the disappearance of ankle clonus in all patients. When antagonist muscles were present, splints were no longer needed after neurotomy. Cinematic analysis showed that tibial neurotomy improved angular variations of the second rocker of the ankle during stance. CONCLUSION: Peripheral neurotomies are simple and safe procedures for the treatment of lower limb spasticity and should be routinely used in general neurosurgery practice.

Adolescent↗
PubMed1997

Extracted teeth: decontamination, disposal and use.

With the advent of medical waste and OSHA infection control regulations, many practitioners are unsure about the legal, proper handling of extracted teeth. This article outlines the options available for the disposal of extracted teeth and explains the role each regulatory agency plays in the process.

California↗
PubMed1996

Amyloid angiopathy-related cerebellar hemorrhage.

BACKGROUND: The posterior fossa localization of amyloid angiopathy-related hemorrhage is very unusual. Less than 10 cases have been previously reported. Surgical management of amyloid angiopathy-related hemorrhage is the subject of controversy. RESULTS: Typical aspects of amyloid angiopathy were found within the surgically removed biopsies of 71-year-old nonhypertensive, nondemented woman suffering cerebellar hemorrhage. CONCLUSIONS: Amyloid angiopathy-related hemorrhage could occur in the cerebellum, and diagnosis might be suspected when no past history of mental deterioration and/or arterial hypertension are present and when angiography rules out vascular malformation. Surgical management seems to have the same restricted indications as in other brain areas.

Aged↗
PubMed1995

[Paraganglioma of the cauda equina. Clinical aspects and MRI. Apropos of a case].

The clinical and imaging features of a paraganglioma of the cauda equina are presented. A peridural anesthesia revealed the cauda equina compression syndrome in a 68 years old man who presented first with a urinary retention. Total surgical excision of a long round-shaped encapsulated tumor was uneventful. Macroscopically this lesion filled up the spinal canal and resembled to a meningioma. It was firmly attached to the filum terminale. Adjacent large arterialized vessels visible on MRI were spared. Although the diagnosis could be evoked pre-operatively on some suggestive patterns on the MRI, the pathological findings finally confirmed the diagnosis of paraganglioma. Along with the evidence of specific light microscopic features, the use of an immunocytochemical demonstration of synaptophysine in these tumors allows a confident diagnosis to be made.

Aged↗
PubMed1993

Solid-state conformations of 2,6-cis- and 2,6-trans-substituted dihydropyran-3-ones.

2,6-Dihydropyran-3-ones carrying substituents at C-2 and C-6 in cis-arrangement invariably adopt half-chair conformations in which the ring oxygen and the carbon atom next to the carbonyl group are above and below, respectively, the plane formed by the other four carbon atoms, i.e., the 2Ho or oH2 conformation. In the case of a trans-arrangement of 2,6-substituents, the geometry of the pyranoid ring falls into the Bo,6<-->Eo<-->2Ho or thet inverse o,6B<-->oE<-->oH2 section of the conformational cycle, depending on the absolute configuration of the compound; for two of the dihydropyranones, 4B and 6, a unique skew-boat (SBo,6) conformation, fixed between the Bo,6 and Eo geometries, was ascertained, which previously has only been observed for pyranoid enelactones.

Carbohydrate Conformation↗
PubMed1992

Syntheses of branched-chain sugars with push-pull functionality.

The reaction of methyl 4,6-O-benzylidene-3(2)-deoxy-alpha-D-erythro- hexopyranosid-2(3)-ulose with carbon disulfide, alkyl iodide, and sodium hydride gave methyl 4,6-O-benzylidene-3(2)-[bis(alkylthio)methylene]-3(2)-deoxy-alpha-D- erythro-hexopyranosid-2(3)-uloses. Methyl 4,6-O-benzylidene-2-[bis(methylthio)-methylene]-2-deoxy-alpha-D- erythro-hexopyranosid-3-ulose (5) reacted with aromatic amines to give, in a rearrangement process, N-aryl-2-aryliminomethyl-4,6-O-benzylidene-2-deoxy- alpha-D-erythro-hex-1-enopy-ranosylamin-3-uloses. The reaction of 5 with hydrazine hydrate afforded 5-methylthio-(methyl 4,6-O-benzylidene-2,3-dideoxy-alpha-D-erythro-hexopyranosido)[3,2- c]pyrazole.

Carbohydrate Conformation↗