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Biomedical subjects

E Crespo

Publications and source records attributed to E Crespo.

47 records · Page 3Linked to original sources
PubMed1984

Left ventricular wall motion in patients with Chagas's disease.

The effect of early chronic Chagas's disease on the timing and extent of regional left ventricular wall motion was studied with a frame by frame analysis of left ventriculograms in nine patients and compared with those in 19 normal subjects. In all the patients there was hypokinesis or akinesis in the anteroapical region together with delay in the onset of inward movement. Hypokinesis of the proximal inferior segment was also present, but the time of onset of inward motion here was normal. These differences can be explained on the basis of regional asynchrony within the normal left ventricle, where anteroapical wall motion is delayed with respect to that elsewhere. Thus contraction of the diseased anteroapical segment starts against an appreciable pressure and so may be isometric, whereas the affected proximal inferior segment starts contracting earlier against a lower pressure and so is able to shorten. No abnormalities of wall motion were seen during isovolumic relaxation despite segmental involvement, which is a distinctly different finding from that in patients with coronary artery disease. This may be due partly to the absence of incoordinate relaxation in Chagas's disease and partly to myocardial involvement by Chagas's disease in the mid-anterior segment. This is the site of rapid early diastolic wall thinning, which has been put forward as a major mechanism of normal rapid ventricular filling and whose premature activity causes disturbances in regional wall motion before mitral valve opening when relaxation is incoordinate. Thus quantitative analysis of both the timing and amplitude of wall motion indicates fundamental differences between Chagas's disease and coronary artery disease, when a less complex analysis would have shown a similar pattern of segmental dysfunction in both. Since the effect of the same pathological process on wall motion varies with the site of ventricular involvement, the importance of the disturbances seen in Chagas's disease becomes apparent only when the non-uniformity of normal left ventricular structure and function is taken into account.

Angiocardiography↗
PubMed1984

[Anti-measles antibodies in the first 2 years of life].

In order to achieve a better understanding of the epidemiology of measles in Spain to foster vaccination policy in our country, we have conducted a serological survey of measles antibodies in children between birth and two years of life in the urban population of Madrid. Authors have established the rate at which maternal antibodies are lost in these children below 15 months of life. The results indicate that, in general maternal antibodies have already disappeared at 9 months. Vaccination can thus be indicated around this age.

Age Factors↗
PubMed1980

[Copper and zinc levels in nails of children with cystic fibrosis, carriers and healthy controls (author's transl)].

Authors study copper and zinc levels and the ratio zinc/copper, by atomic absorption spectrophotometry, in nails of children with cystic fibrosis, suspected carriers, relatives of patients, and healthy controls, the latest forming two different groups. A significant increase of copper and zinc levels in nails of cystic fibrosis patients compared to the controls is found. However, there were no significant differences with regard to the carriers. It is concluded that, in spite of significant findings, this method should not be used routinely because of the large fluctuations produced by the weight of nails, the sensitivity of the resonance line and the variations in these elements concentration on nails surface.

Adolescent↗
PubMed1980

[Congenital factor VII deficiency (author's transl)].

A new case of factor VII congenital deficiency is presented in a four year old girl, with a factor VII level of 3.9%. The patient had no history of bleeding and her coagulation disorder was a casual finding. Clinical features of the disease and its therapeutic guidelines are discussed. It seemed appropriate to continue the study in order to evaluate the factor VII capacity of inhibiting an specific antibody, to confirm heterozygosity of partents and to prove that this case is a genetic variant of factor VII deficiency with good prognosis.

Child, Preschool↗
PubMed1977

Evolution of bacterial sensitivity to fosfomycin in the Cindad Sanitaria 'Francisco Franco' in Barcelona.

A revision was done of the sensitivity of isolated germs in urine cultures and various other cultures to fosfomycin from 1972 to the present in the Ciudad Sanitaria 'Francisco Franco' in Barcelona. The results obtained were analyzed. The general observation was that of a fairly uniform behavior in the majority of germs that had shown an increase in resistance in 1973, and a clear tendency to a decrease in resistance in 1974 and 1975 with the exception of P. rettgeri (Lact.+) and P. morganii.

Anti-Bacterial Agents↗
PubMedDate not supplied

[Usefulness of ambulatory blood pressure monitoring in kidney disease].

High blood pressure is both a cause and a manifestation of renal disease. It has an increasing prevalence among renal patients renal function is declining. Blood pressure is not a constant value, but it shows a high intrinsic and extrinsic variability. It is common to find striking discordances between blood pressure values and target organ damage. The average values obtained through ambulatory blood pressure monitoring (ABPM) are better related with cardiovascular morbility and mortality than office measurement, even in renal disease patients. We report the experience with ABPM on 51 renal patients. None of them was on renal replacement therapy. In 7 out of 14 non treated patients ABPM showed clinic hypertension only. Mean age of truly hypertensive patients was higher, but this difference was not significant (normotensive 31.7 +/- 17.1; hypertensive 49.4 +/- 17.9 years, p < 0.1). There were no sex differences (normotensive, 5 males and 2 females; hypertensive, 4 males and 3 females). Three normotensive patients had chronic renal failure, and as did 6 hypertensive patients (p < 0.1). There were no differences in night-time drop either for systolic (normotensive 3.7 +/- 3.5 hypertensive 6.1 +/- 8.9%) or for diastolic blood pressure (normotensive 10.4 +/- 4.7 hypertensive 6.2 +/- 8.9%). Thirty-seven patients who were on antihypertensive drug treatment: 23 (68.2%) showed hypertension after the ABPM and 14 (37.8%) have normal blood pressure values, more over, 4 of these 14 patients showed hypotension. There were neither age differences between the groups (normotensive 49.0 +/- 12.5, hypertensive 51.9 +/- 15.4 years), nor sex differences (normotensive 9 males and 5 females, hypertensive 11 males and 12 females). The prevalence of renal failure was similar (normotensive, 85.7%; hypertensive, 82.6%). Mean night-time drop was not different (SBP, normotensive 6.1 +/- 7.6 hypertensive 7.2 +/- 7.6%; DBP, normotensive 9.0 +/- 8.3 hypertensive 13.5 +/- 7.6%). ABPM is a helpful diagnostic tool in renal disease as in the non complicated essential hypertension patient, both for experimental and for clinical purposes.

Adolescent↗
PubMedDate not supplied

Atopic dermatitis and food allergy.

In order to determine the importance of food sensitization in the etiopathogenesis of atopic dermatitis, we performed a study on 74 patients who fulfilled a previously suggested diagnosis criteria. Of these patients, 17.5% presented allergic rhinitis and 62.2% had associated bronchial asthma. We found that in 64.9% of the patients there was a food sensitization, with milk (36.5%), egg (35.1%) and fish (21.6%) being the most frequently involved. We also observed that 34% of the patients were sensitized to Dermatophagoides pteronyssinus and 24.3% to pollen. These sensitizations were confirmed by means of skin tests, specific IgE and antigen-specific histamine release test. The patients underwent a 3-year follow-up in order to find out the clinical evolution once the causal food was avoided and/or a symptomatic treatment was prescribed. The group of patients with no food sensitization was significantly different from the group with food sensitization: in the first group only 20% of the patients presented a very good clinical evolution (asymptomatic), while in the second group, in 71.4% of the patients the symptoms completely stopped. Nevertheless, in the first year follow-up, we found no significant differences between the two groups. In conclusion, a diet avoiding the causal food combined with a suitable symptomatic treatment, led to an important remission of the skin manifestations in children diagnosed with atopic dermatitis.

Adolescent↗