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Biomedical subjects

E Coraboeuf

Publications and source records attributed to E Coraboeuf.

At least 73 records · Page 4Linked to original sources
PubMed1976

Control of ionic permeabilities in normal and ischemic heart.

The major ionic conductances underlying electrical activity in cardiac tissues are described. The participation of electrogenic active transport in electrical phenomenon and the influence of metabolic inhibition on cardiac action potentials are briefly summarized. Some electrophysiological effects of lactate and acidosis, such as might be induced by ischemia, are described. In dog Purkinje fibers, lactate (20 mM pH 7.0) may induce transient periods of arrhythmias. Acidosis decreases rapid sodium conductance, slow calcium-sodium conductance, and anomalous and delayed rectifications in frog atrial fibers. CO2-induced acidosis (20% CO2, pH 6.6) may alter the repolarization phase of the action potential in dog Purkinje fibers, presumably because it decreases potassium conductance. Alterations consist of partial depolarizations (humps) that result in reexcitation of the fibers and lead to a maintained depolarization. It is proposed that acidosis induces a decrease in potassium conductance that can be responsible for ectopic foci causing arrhythmias during ischemia.

Action Potentials↗
PubMed1976

[Pathogenesis of arrhythmias in acute myocardial infarction].

Over the last few years, much experimental work has been done to try and elucidate the pathogenesis of disorders of rhythm in myocardial infarction. The role of bradycardia during the first few hours has been discussed, and the use of atropine has been criticised. Some light has been thrown on the importance of the Purkinje network in the infarcted zone. Some new concepts have been applied to the disturbances in exchange across membranes. The authors present the results of a series of experiments on the action of lactate and that of acidosis. The latter is responsible for upturns in the descending phase of the action potential these can cause re-excitation, and give rise to responses containing 2, 3 and even more propagated action potentials.

Acid-Base Equilibrium↗