Function of the diaphragm in patients with severe hyperinflation.
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Biomedical subjects
Publications and source records attributed to E Clark.
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The ultrasonic findings of a case of ileocolic intussusception are presented. The clinical findings usually seen in this condition are reviewed. The atypical presenting symptoms of adult forms of this condition are emphasized.
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Different doses of aspirin, indomethacin, paracetamol, benorylate, and sodium salicylate were taken by four volunteers. The minimal dose that altered a platelet function test and the persistence of this alteration at different dose levels were studied. Minute doses of indomethacin (0.035 mg/kg) were effective but the effect of even a large single dose did not persist. A tenth of the therapeutic dose of aspirin (1 mg/kg) was effective, and higher doses altered the platelets' function for several days. Benorylate in a high therapeutic dose gave aspirin-like results. Paracetamol and sodium salicylate were relatively inactive. The persistence of the aspirin effect may be related to the acetyl group. These findings are surveyed in relation to a general theory of the action of anti-inflammatory drugs.
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