Biomedical subjects
Publications and source records attributed to E Cerný.
The authors give an account of a bioptically revealed adenocarcinoma of the large bowel which was combined with a carcinoid. The carcinoid constituent of the tumor had massive metastases as revealed by the postmortem examination.
Unusual sort of breast carcinoma metastases to the liver, combined with pseudolobular transformation, was found in an autopsy of 68-year-old female after complete oncological treatment. Nodes of parenchyma in abundant connective tissue nearly consisted of tumour cells. Terminology and pathogenesis were discussed.
The authors investigated in experiments on rabbits the course of recovery of liver injuries after treatment with the fibrin glue Tissucol, as compared with a control group of animals where the injured liver was not treated. Healing was followed-up at several time intervals. Rupture of the liver left to spontaneous healing was at first unsatisfactory from the histological aspect (wide demarcation margin near the necrosis). Subsequently the margin disappeared however. The scar was minimal after two months and were no manifestations of inflamed parenchyma surrounding the scar. When Tissucol was used, as a rule favourable healing was achieved. Scarring was satisfactory although the connective tissue was somewhat wrinkled and the scar was not linear. On the whole the tissue glue Tissucol is favourable in the final stage despite the fact that during healing a granulomatous reaction to the glue developed and the proliferation of the minor biliary pathways persisted also in the final stage of the experiment.
The assessed elevated catecholamine levels in the organism during substantial physical or mental stress lead to changes in the heart rate and to intensification of contractions. The demands of the heart muscle as regards increased oxygen supplies and are not met. This may have serious consequences for the patient. The authors wanted to find out therefore whether the beta-blocker celiprolol will be able to reduce the negative effect of large amounts of catecholamine in the organism and thus play a part in the prevention of myocardial damage. When celiprolol was administered half an hour before isoprenaline, the extent of necrosis caused by catecholamine was reduced. When administered half an hour after isoprenaline administration, the marked protective effect was no longer observed. The necroses in the heart muscle were similar as in animals given catecholamine only.
Ten deaf-mute subjects with total vestibular areflexia were subjected to positional tests, i.e. assessment of the postural subjective vertical and horizontal plane by deviations in the frontal and sagittal plane. The tests were performed in the author's modification of a Grahe table. Comparison with the results of 10 healthy subjects revealed that extinction of vestibular activity increases the inaccuracy of assessment of the body position in space. The conclusion is: the vestibular (otolith) apparatus supplements and makes the activity of all other gravireceptors more accurate but not hold a dominant place among them.
The authors investigated in experiments on rabbits healing of liver incisions under various circumstances: spontaneous healing, liver incisions treated by suture by application of the tissue glue Tissucol, the collagenous haemostatic felt Collastypt combined with one stitch. Healing was followed up after several time intervals. From normal, i.e. the group of spontaneous healing, differed the groups treated by Tissucol and Collastypt where marked encapsulating fibrous tissue reactions round the necroses on the wound margins were found with numerous eosinophils as a transient phenomenon. The final result (with a maximum of cca two months) was adequate in all groups--as a rule a thin fibrous tissue scar with few remnants of atrophic hepatic trabeculae. In the treatment of small injuries it seems best to use the collagenous haemostatic Collastypt. In the treatment of sutures in rare instances a large number of leucocytes was found in the area of the necrosis and stitches, perhaps as result of contamination of the wound or sewing material.
The authors investigated in two groups of animals (rabbits, goats) the influence of the prolonged presence of a cannula in the trachea. The greatest differences were found in all groups of animals in the area of the stoma. In rabbits with the period of cannulation the originally slightly suppurative inflammation of the wall and adventitia changed gradually into a non-suppurative inflammation which reduced and disappeared at the end of the experiment. In the group of goats the proliferative exudative inflammation near the stoma with a predominance of leucocytes persisted, while in a more peripheral direction from the stoma the inflammation became non-suppurative with a predominance of mononuclear cells. The prolonged presence of a plastic cannula without a cuff thus did not induce a situation leading to permanent anatomical stenosis.
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In this experimental work we evaluated the effect of preventively administered Cordarone on the myocardial damage of rats, caused by isoproterenol. Cordarone had prevented the early mortality of rats up to 1 h, however, after the administration of high doses of Cordarone the late mortality of experimental animals was increased. In the group of rats, which were treated by Cordarone there were almost no small necroses of myocardium, which were, however, contrary--very often found in the control animals. We guess that this effect of Cordarone is caused by its influence on the heart rate, which is slowing down, by its antiarrhythmic effect and by its efficiency to improve the perfusion of myocardium by its power to decrease the resistance of coronary vessels.
Influence of Neo-Gilurytmal was studied upon catecholamine heart lesion in rats of two weight categories: In bigger ones (350-420 g) the lesion was diminished, in smaller animals (200-230 g) any protective influence did not occur. Sensitivity of myocardium to Neo-Gilurytmal is supposed to concur with that to catecholamine effect in rats of increasing weight.