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Biomedical subjects

E Cavatorta

Publications and source records attributed to E Cavatorta.

At least 19 recordsLinked to original sources

Plasma concentration, urinary excretion and renal clearance of L-carnitine during pregnancy: a reversible secondary L-carnitine deficiency.

Plasma concentration, urinary excretion and renal clearance of free, total and esterified L-carnitine were monitored monthly in 14 women during the last 6 months of pregnancy and 1 month after delivery. Plasma concentration and renal clearance measured 1 month after delivery overlapped with normal values for females of comparable age, and were considered the reference values for further comparisons. Plasma concentration of free, total and esterified L-carnitine decreased during pregnancy, reaching values as low as half of those measured 1 month after delivery, whereas urinary excretion and renal clearance, mainly of L-carnitine esters, increased, with renal clearance reaching a peak at the 16th week of pregnancy. Pregnancy thus leads to a reversible secondary deficiency of L-carnitine. The involvement of L-carnitine in the excretion of an excess of acyl-S-coenzyme A groups to prevent a possible systemic acidosis, as well as hormonal changes and a reduction of L-carnitine biosynthesis, could play a significant role in the variations in L-carnitine metabolism encountered in pregnancy. As physiological components of L-carnitine are excreted via a saturable tubular reabsorption, their threshold seems to follow plasma concentration, even when they decrease markedly, as in pregnancy.

Adolescent

Fetal distress: role of cardiotocography.

The FHR monitoring in 320 patients with fetal distress were randomly analyzed and revised over 16 years. The aim of our study, in so long a period, was to evaluate the role of cardiotocography in order to preserve the fetus from irreversible damage. The results show a progressive improvement of neonatal outcome, due to the development of the experience with this method, and to the improvement in interpretative criteria. However, cardiotocography showed its limits, and the moment has come to seek new integrative methods to associate cardiotocography with a continuous monitoring of the fetal status.

Adult

[Echographic diagnosis of fetal malformations].

The Authors report their experience about ultrasound diagnosis of congenital anomalies, related to 15 cases from approximately 4000 gravides. They emphasize the impossibility to carry out total antenatal population screening by sonar and the usefulness to carefully select the gravidas at high risk for harboring a fetus with a birth defect. They also suggest that, in looking for physical defects, it is best to make ultrasound examination at 17a-18a weeks' gestation; at this moment, the ultrasound evaluation is particularly favorable for diagnosis and treatment.

Adult

[Thermal therapy in gynecology].

The Authors consider the importance of Thermal Therapy in a large part of gynaecological diseases. They emphasize of its utility mostly in the chronic flogosis of the female genitalia. However other indications emerged from this research, such as female sterility, pelvic vascular disease, climaterie syndrome and post-operatory affects.

Balneology

[Congenital cardiac disease: cardiotocographic manifestations (author's transl)].

The Authors have studied in retrospect the cardiotocographic registrations of women who had given birth to foetus affected by congenital cardiac disease. The observations of several authors (Heinriche Seideschnur; Fischer) are confirmed that persistent bradycardia in pregnancy or in labour could be a sign of a congenital cardiac anomaly. Furthermore, the high incidence of C.T.G. alterations are noticed (in the form of decelerations and significant reduction of the oscillation amplitudes) in the registrations of foetus affected by such cardiac disease.

Female

[Down syndrome: cardiotocographic alterations (author's transl)].

The Authors describe the results of a study on the cardiotocographic tracings during labour of pregnant women, whose fetuses were affected by Down syndrome. The high incidence of cardiotocographic alterations in these fetuses does not seem to be in relation with congenital cardiac disease.

Adult

[Serum fibrin degradation products in 13 cases of E.P.H. gestosis (author's transl)].

Intravascular coagulation causes fetal risk, because it produced placental damage in E.P.H. gestosis. F.D.P. values are above the normal range of the third trimester in 11 out of our 13 cases. Fetal risk is revealed by pathological C.T.G. patterns; fetal death occurred in 4 cases. Therefore, high F.D.P. values are considered D.I.C. indexes, and a sign of fetal risk.

Disseminated Intravascular Coagulation

[Prenatal biophysical monitoring: stress tests].

Intrapartum fetal monitoring has provided a method by which the clinician can more accurately determine the status of the fetus during labor. More recently, investigations have been directed toward antepartum FHR monitoring studies to determine fetal well-being prior to the onset of labor. In this study, the results of "stress" monitoring are presented. The Authors have used three types of stress-tests: 1) oxytocin stress test 2) step-test 3) Oxygen stress test. The positive tests appears to correlate meaningfully with intrauterine compromise and neonatal status.

Adult