A clinico-pathologic presentation. Irritation from monomer.
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Biomedical subjects
Publications and source records attributed to E Cataldo.
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Oral hairy leukoplakia (HL) is a lesion that occurs predominantly on the tongue in HIV-infected persons. Evidence strongly indicates that HL is related to the presence of Epstein-Barr virus in the epithelial cells. The lesion appears on the lateral border of the tongue as a painless, white plaque varying in size from a few millimeters to extensive lingual involvement. Histopathologically, the characteristic findings are hyperparakeratosis, hyperplasia, and ballooning of prickle cells resembling koilocytosis. HL is now considered a frequent, early, and specific sign of HIV infection and a strong indicator that AIDS will develop in the patient. We report on two cases of HL with marked oral mucosal involvement with extension to the pharyngeal mucosa.
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A 15-year-old boy, in the case presented in this article, had 13 unerupted teeth, each associated with hyperplastic pericoronal tissue that showed histologic features suggestive of the WHO type of odontogenic fibroma. The etiology, clinical features, radiographic findings, and histopathology of the odontogenic fibroma are reviewed. It is suggested that the unusual pericoronal findings represent a hamartomatous change.
In the oral cavity, differentiation between reactive and neoplastic lymphoproliferative lesions can, at times, be very difficult. We report an unusual case in which immunohistochemical findings were necessary to determine that the lesion was reactive despite the original interpretation of malignant lymphoma. The relationship of this lesion to atypical histiocytic granuloma, angiolymphoid hyperplasia with eosinophilia, and traumatic ulcerative granuloma with stromal eosinophilia is discussed and possible pathogenetic mechanisms are proposed. The value of immunohistochemistry in the diagnosis of extranodal lymphoproliferative lesions is emphasized.