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Biomedical subjects

E Carlsen

Publications and source records attributed to E Carlsen.

67 records · Page 4Linked to original sources
PubMed1981

Relapse of duodenal ulcer after treatment with trimipramine/antacids or cimetidine/antacids.

Ninety-three patients with duodenal ulcer were treated with trimipramine, 25 mg at night; cimetidine, 400 mg at night; or cimetidine, 1000 mg/day. In addition, all patients were given 20 ml antacids 1 and 3 h after meals. The healing rates after 6 weeks' treatment were 86%, 85%, and 100% in the three groups, respectively (differences not significant). After healing of the ulcers 88 of the patients were checked monthly during 1 year to study relapse rate. Endoscopy was performed on recurrence of symptoms suggesting relapse and after 6 and 12 months in all asymptomatic patients. Relapse was diagnosed in 64% of the patients in the trimipramine-treated group, in 48% in the 400 mg cimetidine group, and in 54% in th 1000 mg cimetidine group (differences not significant). The results suggest that ulcer recurrence is not commoner after treatment with standard dose of cimetidine than after a low dosage of cimetidine or trimipramine.

Antacids↗
PubMed1981

The influence of hormones and drugs on gastric pepsin secretion. The role of vagal innervation.

Seven double-pouch dogs with one vagally innervated Amdrup pouch (AP) and one denervated and denervated mucosa at the same time in the same animal. Stimulation was done by food, a mixture of liver, heart and bonemeal, 10 g/kg. Cimetidine, 25, 50, 100, 200, and 400 mg; atropine, 0.031, 0.125, 0.5 and 1.0 mg; somatostatin, 0.5, 1.0, and 2.0 micrograms/kg/h; and secretin 2 U/kg/h, were given 60 min after the meal, one single dose on each day. Atropine and somatostatin lowered pepsin secretion in both pouches, significantly more in denervated mucosa for all doses of somatostatin and for the lower doses of atropine. Higher doses of atropine nearly abolished the secretion in both pouches. Cimetidine lowered pepsin output only in denervated mucosa. In innervated mucosa the output was unchanged or significantly increased (50 mg) by cimetidine. Secretin increased pepsin output significantly in both pouches, more in innervated mucosa. When the infusion of somatostatin was topped, a marked rebound effect was seen in the innervated pouch.

Animals↗
PubMed1980

Prognostic value of the pentagastrin and insulin tests after proximal gastric vagotomy.

A review was made of 72 patients 3--6 years after proximal gastric vagotomy without drainage operation for duodenal ulcer. To assess the prognostic value of gastric acid secretory analyses, the correlation between the clinical results and the pentagastrin and insulin tests made preoperatively and 2 months postoperatively was determined. The preoperative secretory analyses showed no such correlation. Comparing recurrences and non-recurrences, only the basal acid output 2 months postoperatively showed any discriminatory ability, 2 mmol/h representing the critical level. When clinically satisfactory and clinically unsatisfactory patients were compared, the insulin-stimulated acid output and peak acid concentration 0--45 min after stimulation, in addition to the basal acid concentration and output, had statistically significant discriminatory levels. There was no correlation between the clinical results and seven different criteria for positive insulin response.

Evaluation Studies as Topic↗
PubMed1980

Treatment of duodenal ulcer with ranitidine, a new histamine H2-receptor antagonist.

Fifty patients with endoscopically verified duodenal ulcer were treated with either 100 mg of ranitidine hydrochloride (corresponding to 89.4 mg of ranitidine base) or identical placebo tablets twice daily under double-blind conditions. One patient did not attend for the second endoscopy and was excluded. Endoscopic examination after 4 weeks of treatment showed that the ulcer had healed in 23 out of 25 patients (92%) treated with ranitidine and in 11 out of 24 patients (46%) treated with placebo (P < 0.01). The ranitidine-treated patients had significantly less ulcer symptoms during treatment. Antacid consumption was also less in the ranitidine than in the placebo-treated group, but the difference was not significant. After 4 weeks in the double-blind study 14 of the 15 patients with unhealed ulcer received open treatment with ranitidine for 4-6 weeks. The ulcer healed in all but one patient. No serious side effects of ranitidine were observed.

Clinical Trials as Topic↗
PubMed1980

Treatment of duodenal ulcer with antacids in combination with trimipramine or cimetidine.

Ninetyfive patients with endoscopically verified duodenal ulcer were randomly allocated in a double blind manner to 3 different treatments. Thirtyfive patients were treated with trimipramine 25 mg nocte, 32 patients with cimetidine 400 mg nocte and 26 patients with cimetidine 200 mg 3 times a day and 400 mg nocte (standard dose). In addition all patients got intensive antacid treatment with LinkR, 20 ml 1 and 3 hours after meals. Two patients were excluded from the trial. After 6 weeks of treatment re-endoscopy revealed healed ulcer in 35 patients (86%) in the trimipramine group, in 32 patients (85%) in the group treated with low dose of cimetidine and in 26 patients (100%) in the group treated with standard dose of cimetidine. The differences in healing rate were not significant. The time until complete relief of pain was significantly longer in the trimipramine group than in the cimetidine groups. The drugs were well tolerated but constipation was reported by 31% of the patients.

Adult↗
PubMed1979

Maintenance treatment of duodenal ulcer patients with a single bedtime dose of cimetidine.

Fifty-eight patients with endoscopically verified duodenal ulcers were treated with cimetidine, 1 g/day, for 6--10 weeks. The ulcers healed in 52 out of the 54 patients completing the treatment (96.3%). Forty-seven of the patients with healed ulcer were randomly allocated to 1 year of maintenance treatment, 23 patients with cimetidine, 400 mg at night, and 24 patients with placebo tablets. In the cimetidine-treated group 2 out of the 20 patients (10%) completing the trial had recurrence of ulceration, whereas 16 out of the 23 patients (70%) completing the placebo treatment had ulcer recurrence (p less than 0.001). The drug was well tolerated and, except for a marked increase in serum transaminases in three patients, no serious side effects were seen.

Adult↗
PubMedDate not supplied

Technical aspects and complications of end-ileostomies.

During a period of 10 years (1980-1990) we constructed or reconstructed 358 end-ileostomies: 224 were primary constructions, 96 were reconstructed by laparotomy, and 38 were local reconstruction. Only 2 ileostomies were primarily located on the left side. The mean length was 5 cm. We had 11.6% reoperations after primary stomy and 7.3% and 7.9% reoperations after reconstruction by laparotomy and local approach, respectively. There were 12.9% and 8.7% reoperations after emergency and elective primary operations, respectively. Closing the lateral gutter or fixation of ileum to the rectus fascia did not influence significantly the number of reoperations. Postoperative discolored stomy did not indicate more dysfunction of the ileostomy. Stenosis of the ileostomy, peristomal fistulas, and peristomal dermatitis were seen in 23 (10.3%), 21 (9.4%), and 18 (8%) of the patients after primary ileostomies, respectively. Patients with Crohn's disease had significantly more of these problems than patients with ulcerative colitis. Only a few patients had retraction of the ileostomy (2.7%), stomal prolapse (1.8%), or parastomal herniation (1.8%). Women had significantly more parastomal herniation than men; otherwise there were no differences between the sexes.

Constriction, Pathologic↗
PubMedDate not supplied

Penile vibratory stimulation and electroejaculation before anticancer therapy in two pubertal boys.

PURPOSE: Because more than 70% of children with cancer become long-term survivors, more emphasis is put on reducing late effects. Cryopreservation of semen and the intracytoplasmic sperm injection technique makes it possible to obtain pregnancy with very poor sperm quality. Two new semen retrieval methods are described that are applicable in pubertal boys with a fertility potential, although not psychologically ready to produce a semen sample, who are likely to become infertile because of anticancer therapy. PATIENTS AND METHODS: Two pubertal boys (aged 14 and 15 years) had a late testicular relapse of pre-B acute lymphoblastic leukemia and Hodgkin disease, stage II, respectively. In patient 1, penile vibratory stimulation (PVS) was tried under general anesthesia without success and electroejaculation (EEJ) was performed. Before alkylating chemotherapy and testicular irradiation, PVS was performed with success in patient 2. RESULTS: An antegrade ejaculate of 0.7 ml with 1% motile spermatozoa and an retrograde ejaculate with 1.6 x 10(6)/ml spermatozoa (5% with fair motility) was obtained from patient 1. An antegrade ejaculate of 1.5 ml with 2.5 x 10(6)/ml spermatozoa (29% with fair motility) was obtained from patient 2. CONCLUSIONS: PVS should be the first choice of treatment because it is noninvasive, simple, and easily applied. Because EEJ requires general anesthesia, it should be used as a second option.

Adolescent↗