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Biomedical subjects

E Carey

Publications and source records attributed to E Carey.

6 recordsLinked to original sources
PubMed1984

Longitudinal development of sleep-related respiratory disturbance in adult humans.

A number of cross-sectional studies have found that sleep-related respiratory disturbance ( SRRD ) is common in elderly adults. This preliminary study reports on samples of middle-aged and elderly humans in good health whose polysomnographically recorded sleep was followed over time. Participants were selected for low levels of SRRD on Time 1 recording. Results indicated an increase in SRRD over the study period. This increase ws not limited to rapid eye movement or nonrapid eye movement sleep; tobacco usage, medication status, and weight gain could not account for the change, although in several cases, modest weight gain was associated with increased respiratory disturbance. These data imply that future studies of incidence of SRRD may reveal changes within a 10-year period, although the pathological consequences of these age-related changes, if any at all, may take a longer period to develop.

Aged↗
PubMed1983

Nightly variation in sleep-related respiratory disturbance in older adults.

This study investigated variation in respiratory disturbance during sleep. Sixty-six healthy elderly subjects (mean age = 67.2) underwent two consecutive nights of polysomnography. Respiratory disturbance was assessed by Respiratory Disturbance Index (RDI), the number of events per hour of sleep. Results indicated an increase in RDI from Night 1 to Night 2. Fourteen subjects increased their RDI by over 2.5, and eight by over 5.0, events per hour on Night 2. The increase was not a function of increased REM on Night 2. Age was positively related to RDI on individual lab nights but unrelated to nightly variation in RDI. Subjects without complaints of insomnia were more likely to show increases in RDI, perhaps reflecting the sounder sleep of this group on the second laboratory night. This study suggests that a single night of polysomnography is likely to underestimate the absolute level of respiratory disturbance seen in a subsequent recording night. Studies placing prevalence of such disturbance in the elderly at approximately 30% are thus likely to be underestimates. Whether this "error" is important will depend ultimately upon the meaning of various absolute levels of respiratory disturbance in healthy older persons.

Adult↗
PubMed1975

Human-to-human transmission of Pseudomonas pseudomallei.

Melioidosis, the clinical manifestation of infection with Pseudomonas pseudomallei, has occurred infrequently in American citizens; almost all reported cases have been in Vietnam veterans, usually associated with respiratory disease. A Vietnam veteran from Mississippi developed chronic prostatitis, with no other clinical manifestations, during service in Vietnam, and P. pseudomallei was isolated from prostatic secretions 2 years after his return to the United States. The patient had had sexual contact with four women including his wife since his return from Vietnam. Vaginal and cervical cultures and serum samples were obtained from the four women, and serum samples and cultures of semen were obtained from the patient. Vaginal swabs and semen cultures were negative for P. pseudomallei. The patient and his wife had hemagglutination titers (greater than 640) diagnostic of P. pseudominallei infection. This occurrence of venereal transmission is the first report of person-to-person spread of P. pseudomallei infection.

Adult↗