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Biomedical subjects

E C Tan

Publications and source records attributed to E C Tan.

At least 73 records · Page 4Linked to original sources

Chemolysis of uric acid stones.

This paper illustrates one of the more satisfying aspects of the treatment of urinary calculous disease. A small series of 8 patients is presented to emphasize the possibility of dissolving uric acid stones by conservative measures thereby saving the patients extensive and often destructive surgical procedures. Patient selection is important for successful therapy. The stone must not be calcified and there must be sufficient function in the kidney. The regime consists of allopurinol 100 mg and sodium bicarbonate 2 to 4 grams given orally three times a day. Treatment period lasted up to six months, with dissolution of stones.

Adult↗

Stone composition and metabolic study in urinary calculous disease.

A series of 178 urinary stones is analysed qualitatively during a three year period from 1980 to 1982. The majority (96%) of stones orginate from the upper tract. Calcium oxalate stones are the commonest entity seen in the western countries but less than 20% of such stones occur locally. A large proportion consists of mixed stones and one third are infective as triple phosphate is present. 20% contain urate as a constituent whereas relatively pure urate stones constitute 4%. The true incidence of pure urate stones is higher (about 10%) as we have been dissolving them with alkalinisation of urine without surgery. Idiopathic hypercalciura occurs in 11.8% and none has persistent hypercalcaemia. Hyperuricosuria which is commoner, occurs in 24% of patients. It is important to identify this group as it results in the formation of metabolically active stones, and they can be treated with allopurinol to prevent recurrence of stones.

Adult↗

Haemorrhagic chronic radiation cystitis--following treatment of pelvic malignancies.

Haemorrhagic chronic radiation cystitis is not an uncommon clinical entity, and should be suspected in patients with painless gross haematuria who have a past history of radiotherapy to the pelvic region. A series of 29 patients with haemorrhagic chronic radiation cystitis were managed in the University Department of Surgery, Singapore General Hospital over a 5 years period from 1979 to 1983. Cystodiathermy was the mainstay of treatment and was successful in controlling haematuria in 27 patients. Two patients developed uncontrolled haematuria, urinary tract infection, septicaemia and died giving mortality of 6.9%. Excellent control of haemorrhage can be obtained with cystodiathermy in the majority of patients. Intravesical instillation of steroid or silver nitrate is used for the more intractable cases, after cystodiathermy. Urinary diversion with or without cystectomy are desperate measures to salvage the severe case and mortality is high.

Adult↗

Optical urethrotomy for urethral strictures--a preliminary report.

24 patients with urethral strictures which were managed with the optical urethrotome are studied. These patients had developed strictures due to previous transurethral reaction of the prostate, and trauma or inflammation of the urethra. In some cases we have not been able to determine the aetiology of the problem. 58% of the patients responded satisfactorily to this mode of therapy. Although a high percentage develop recurrent stenosis, these can be treated by repeated urethrotomy under vision without much morbidity. Resistant cases would need urethroplasty.

Adult↗

Genito-urinary tuberculosis--a local experience on its diagnosis and management.

Though the incidence of pulmonary tuberculosis has been on the decline, the incidence of genito-urinary tuberculosis has not decreased proportionately as the majority of patients have no associated pulmonary tuberculosis. Genito-urinary tuberculosis affects male and female equally and is commonest in the 4th decade of life. The most frequent presentation is that of persistent urinary tract infection in 2/3 of patients and gross haematuria in about 1/3 of our patients. A few may be relatively asymptomatic with loin ache. Though urine culture for acid-fast bacilli is important, diagnosis in most patients was established on histopathology and typical radiological features. The main stay of treatment is medical. The role of surgery is mainly reconstructive, to overcome strictures causing obstruction so as to preserve renal function. Close cooperation between physician and surgeon is important in the management of this disease.

Adult↗

Ureteral reaction to suture material.

Dog ureters were anastomosed end to end using either chromic catgut, polyglycolic acid (PGA), polyglactin-910, or polypropylene sutures. Analysis of luminal diameters, fibrosis, scar vascularity, and inflammatory reaction four and seven months later indicated that in ureters of the uninfected dog the best results were obtained with polyglycolic acid. Ureters anastomosed with catgut gave results that were slightly less acceptable.

Animals↗

Effect of acupuncture on pain threshold measurement of tooth pulp in the monkey.

The effect of acupuncture on pain threshold from tooth pulp stimulation was studied in alert, awake monkeys. Manual manipulation of acupuncture needles in specific acupuncture points in the hands and legs caused a consistent and significant rise in threshold. Some points, such as Ho-Ku (LI-4) and Tsu-San-Li (St-36), produced more prominent analgesic effects than others. Increase of pain threshold was observed also after application of finger pressure on acupuncture points. Acupuncture and finger pressure applied to certain muscle points exhibited similar analgesic effects.

Acupuncture Therapy↗

Major salivary gland tumours.

Forty-one major salivary gland tumours and tumour-like glandular enlargements are reviewed. In nine patients the swellings could not be differentiated from a true neoplasm. The diagnostic and therapeutic approaches to these patients are discussed. The clinical features, diagnostic and surgical management of 31 salivary neoplasms involving the parotid and submandibular glands are correlated with their histological features.

Adult↗