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Biomedical subjects

E C Hughes

Publications and source records attributed to E C Hughes.

At least 19 recordsLinked to original sources
PubMed1988

Noradrenergic cerebral stimulation of sensorineural impaired subjects: yohimbine effects on speech intelligibility and the auditory brain response.

Norepinephrine has been shown to improve signal-to-noise ratios of sensory systems, including that of the auditory system. Yohimbine has been observed to cause a selective increase of cerebral norepinephrine. It was administered in one dose to sensorineurally impaired subjects with the object of improving their speech hearing in noise. Speech intelligibility was measured by the adaptive procedure. Mild, significant improvement was noted in one of the hearing components, "attenuation," and an adverse effect was shown on "distortion," owing to noise. Auditory brainstem response was improved significantly. The objective of temporarily improving intelligibility in noise was not attained.

Aged↗
PubMed1985

Interhemispheric transmission: assessment with vibratory somatosensory evoked potentials.

Interhemispheric transmission time (ITT) was derived from vibratory somatosensory evoked potentials (VSEP) arising in homologous cortical sensory--association areas of normals. Two different vibratory sources, an audiometer bone oscillator or an Optacon, were used to stimulate each index finger independently. ITT was calculated by subtracting the latency of the first major peak over the contralateral cortex (CL) from the latency of the corresponding peak over the ipsilateral area (IL-CL = ITT). Readily identified aberrant values were observed and rejected from the series of measurements leaving clear normal ranges. In addition to providing normal ITT data, clinical correlations were illustrated in two different disorders. Results suggested that important information relating to diagnosis and therapy of brain pathologies affecting interhemispheric transmission can now be made available in both experimental and clinical situations.

Adolescent↗
PubMed1985

Migraine: a diagnostic test for etiology of food sensitivity by a nutritionally supported fast and confirmed by long-term report.

A diagnostic procedure during a nutritionally supported fast week followed by conventional food sensitivity management achieved major improvement for 80% of a migraine panel. This procedure gave a reliable (0.8 correlation coefficient) prognosis on the substantial value of this approach for selection of the treatment of migraine. The study gave two lines of evidence which indicate that migraine has an etiology of food sensitivity.

Adult↗
PubMed1984

Voluntary control of two lateralized conscious states: validation by electrical and behavioral studies.

A subject is described who can voluntarily select and hold either of two qualitatively different states of consciousness. Evidence is presented which confirmed differential left or right hemisphere dominance in each state. Asymmetries of EEG alpha and task performance scores indicated a state-dependent shift in functional lateralization. Evoked response studies showed directional changes in rate of interhemispheric transmission correlated with state-related hemisphere dominance. These findings demonstrated that capability for voluntary endogenous control of cerebral dominance under natural conditions.

Adult↗
PubMed1984

Bony entrapment of the superficial peroneal nerve.

Peripheral nerve injury occasionally results from long bone fractures, but bony entrapment of a peripheral nerve occurs infrequently. Bony entrapment of a peripheral nerve is usually associated with upper extremity fractures. In a 34-year-old man bony entrapment of the superficial peroneal nerve occurred in a healed midshaft fibular fracture. The patient complained of progressive pain over the distribution of the superficial peroneal nerve after sustaining a closed displaced tibial and fibular fracture that healed in nonanatomic alignment. Exploration revealed bony entrapment of the superficial peroneal nerve in the fracture callus, with reactive neuroma formation. Excision of the neuroma resulted in complete relief of the symptoms. Persistent pain over the distal anterolateral leg and dorsal foot following a fibular and tibial fracture is usually derived from a compartment syndrome. If this has been ruled out, the differential diagnosis should include bony entrapment of the superficial peroneal nerve.

Adult↗
PubMed1982

Food sensitivity in attention deficit disorder with hyperactivity (ADD/HA): a procedure for differential diagnosis.

A diagnostic procedure developed for adults and children which includes a week-long fast nutritionally supported with a chemically defined diet was applied to a pilot group of children having ADD/HA syndrome. A probable etiology of food hypersensitivity was shown for a majority of the panel with several standard subjective tests. Three neurological tests, one of which was of the corpus callosum, were evaluated as objective measurements of ADD/HA. Management procedures are not discussed. A follow-up at one year showed substantial continuing control for many of the subjects. It is suggested that this type of general diagnostic procedure be employed to indicate for treatment those having food sensitivity as the primary etiology.

Adolescent↗
PubMed1978

Use of a chemically defined diet in the diagnosis of food sensitivities and the determination of offending foods.

A chemically defined diet of low allergenicity was used to provide complete nutritional support for a week in a referred group of 27 patients. Food-sensitive patients remitted 70% of their allergy symptoms, supporting a diagnosis of dominant food etiology. For those the diet was continued while selected foods were orally challenged. Safe diets were thus established in about three weeks of largely patient-executed effort. Patients without remission were given concentrated attention toward establishing other etiologies. Remission was thus achieved in 85% of the cases.

Adolescent↗
PubMed1976

The effect of enzymes upon metabolism, storage, and release of carbohydrates in normal and abnormal endometria.

This paper presents preliminary data concerning the relationship of various components of glandular epithelium and effect of enzymes on metabolism, storage, and release of certain substances in normal and abnormal endometria. Activity of these endometrial enzymes has been compared between two groups: 252 patients with normal menstrual histories and 156 patients, all over the age of 40, with abnormal uterine bleeding. Material was obtained by endometrial biopsy or curettage. In the pathologic classification of the group of 156, 30 patients had secretory endometria, 88 patients had endometria classified as proliferative, 24 were classified as endometrial hyperplasia, and 14 were classified as adenocarcinoma. All tissue was studied by histologic, histochemical, and biochemical methods. Glycogen synthetase activity caused synthesis of glucose to glycogen, increasing in amount until midcycle, when glycogen phosphorylase activity caused the breakdown to glucose during the regressive stage of endometrial activity. This normal cyclic activity did not occur in the abnormal endometria, where activity of both enzymes continued at low constant tempo. Only the I form of glycogen synthetase increased as the tissue became more hyperplastic. With the constant glycogen content and the increased activity of both the TPN isocitric dehydrogenase and glucose-6-phosphate dehydrogenase in the hyperplastic and cancerous endometria, tissue energy was created, resulting in abnormal cell proliferation. These altered biochemical and cellular activities may be the basis for malignant cell growth.

Adenocarcinoma↗