Biomedical subjects
E C Bonard
Publications and source records attributed to E C Bonard.
[Pickwickian syndrome or Dickens betrayed].
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[Is vaccination still necessary?].
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[The rhinoceros horn syndrome (an unusual form of neuropathy and arthrosis of the feet)].
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[Recurrent erysipelas due to Streptococcus G].
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[Medicine and parallel medicines].
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[Granulomatous hepatitis and portal hypertension. Sarcoidosis? Primary biliary cirrhosis? Brucellosis?].
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[Circulating carcinoembryonic antigen, markedly elevated and persistent without discernible cancer].
A markedly elevated circulating CEA level was observed in January 1978 in a 40-year-old male patient who complained of functional digestive disorders consisting of 2-3 bowel movements at the end of each night. During follow-up of more than 3 years the CEA level was always found to be higher than 300 ng/ml as determined on 12 different blood samples using 3 different assays: the Hansen assay, our own inhibition radioimmunoassay performed on perchloric acid extract of serum, and a newly developed solid phase non-competitive enzyme immunoassay involving monoclonal anti-CEA antibody. The clinical evolution showed no aggravation of the persistent but mild bowel troubles, i.e. no real diarrhea or blood in the stool. The patient enjoys excellent general health and shows no weight loss. Barium enema, colonoscopy and extensive investigation by computerized axial tomography showed no evidence of primary or metastatic tumor. Apart from CEA, the blood chemistry was within normal limits. Six members of the patient's family have normal CEA levels. A possible explanation for this unique case of marked and persistent elevation of circulating CEA without evidence of cancer is discussed.
[A very odd jaundice: clinical dialogue in the manner of Maurice Roch].
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[St. Gothard's anemia].
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[General internal medicine].
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[Suppurative thyroiditis caused by anaerobic germs].
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[Farmer's lung: epidemiologic survey at the piedmont of Jura Mountains in Vaud (preliminary report)].
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