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Biomedical subjects

E Burghardt

Publications and source records attributed to E Burghardt.

At least 55 records · Page 3Linked to original sources
PubMed1979

[Carcinoma in situ of the uterine cervix: treatment (author's transl)].

Persisting dysplasias are nothing but carcinomas in situ with special differentiation. As such they become directly invasive and are differently located as classical carcinomas in situ. Intraepithelial lesions arise in clearly defined fields and do not spread into neighbouring epithelia. Most lesions are located within the cervical mucosa and less frequent in the region of original squamous epithelium. Treatment must be based on the knowledge of changes being truly intraepithelial and upon their extent. When primarily extirpating the uterus such knowledge is not available. Of 160 cases of primary hysterectomy two patients died of cancer. Vaginal hysterectomy produced better results than the abdominal. Electrocoagulation, cryosurgery and laser treatment destroy lesions without exact knowledge of their extent. Conisation combined with careful sectioning of specimen gives the best survey of the lesions. Of 1 219 conisation cases conisation was the only therapy in 918 patients. None of these died of cancer.

Carcinoma in Situ↗
PubMed1978

Clinical experience in the application of the tissue pH electrode.

Only after placing the pH electrode through an incision could its point enter deep enough into the tissue. The storage of the pH electrode in a reference buffer considerably improved the stability of the electrode. The ECG electrode is at present the weakest link in the realization of continuous pH measurements. Improvements should be effected mainly with the ECG electrode, the electrode cable and the application instruments.

Electrocardiography↗
PubMed1978

[Microcarcinoma of the cervix uteri (author's transl)].

Microcarcinoma in the true sense of the word must be distinguished from so-called early stromal invasion. A clear diagnosis must be based on the histological investigation of an adequate biopsy specimen which encompasses the entire changes and enalbes tumour measurement in all three dimensions. With increasing experience it was recognized that the mortality due to microcarcinoma was very low even when limited surgery was performed. When only clearly defined cases were considered, the mortality was nill in early invasion and merely 1.2% in microcarcinomas with a fictitious volume of up to 500 cmm. Both morphological signs of regression of invasive buds and recent knowledge of tumour immunology point to the effectiveness of immunological defence reactions, which are directly related to the tumour mass. A correctly diagnosed microcarcinoma represents a still-localized disease process unless other speical criteria such as lymphatic invasion point to the possibility of discontinuous spread. The method of treatment must be chosen between the extremes: When the danger of metastasis may be neglected local excision of the total diseased area will suffice; in the opposite case, radical operation with lymphadenectomy is indicated. Limited treatment of a microcarcinoma is only justified following clear definition of the lesion based on adequately removed and histologically accurately analyzed biopsy material.

Biopsy↗
PubMed1978

Local spread and lymph node involvement in cervical cancer.

In 150 cases of carcinoma of the cervix the specimens obtained by radical hysterectomy and lymphadenectomy were examined by means of giant frontal section preparations which included adjacent parametria. Serial step sections of lymph nodes were performed. There were 44 cases of Stage IB, 13 of Stage IIA, and 93 of Stage IIB. Lymph node involvement was 16%, 33%, and 37%, respectively. The size of each cervical tumor was expressed in square millimeters as an "area-equivalent," the product of its vertical and horizontal diameters in the frontal plane. Cross relationships of tumor size, incidence of lymph node metastasis, border zone spread, and parametrial involvement were studied and are discussed. It is concluded that tumor size gives a better indication of tumor behavior than does clinical staging and constitutes an objective method of classifying tumors that the latter cannot attain.

Female↗