Biomedical subjects

E Buonocore

Publications and source records attributed to E Buonocore.

At least 73 records · Page 4Linked to original sources

PubMed1979

Carbon-11-labeled amino acids for the rectilinear and positron tomographic imaging of the human pancreas.

Modification of the Bücherer-Strecker amino acid synthesis facilitated the production of DL-[11C]tryptophan and DL-[11C]valine for clinical trials in patients with proven or suspected pancreatic disease. Examples of rectilinear scans and tomographic images of the pancreas are presented in this initial paper. Positron computed tomography was done with the ORTEC ECAT system. Rapid localization of these C-11-labeled amino acids and fast clearance from the plasma permit almost immediate examination following i.v. injection. Illustrative images include the normal pancreas, pancreatitis, and pancreatic carcinoma. The use of positron tomobraphy with C-11-labeled DL-tryptophan and DL-valine appears to offer a new and promising diagnostic modality for the detection and study of pancreatic diseases.

Carbon Radioisotopes↗

PubMed1978

Flow-directed balloon catheterization for aortofemoral arteriography using the axillary artery approach.

An axillary artery approach is occasionally necessary in the evaluation of the abdominal aorta and peripheral arteries in patients with severe and complicated arteriosclerotic disease. Difficulty may be encountered in directing the catheter into the descending aorta in patients with extremely tortuous and elongated aortic arches. Use of flow directed angiographic balloon catheters has made abdominal, pelvic, and lower extremity arteriography readily obtainable using an axillary approach when other methods failed and translumbar aortography was considered hazardous. This might be particularly useful in patients with high abdominal aortic occlusions, in anticoagulated patients, in patients with abdominal aortic grafts, and in some patients with small aortas displaced to the right.

Aged↗

PubMed1976

Non-rheumatic acute mitral insufficiency caused by ruptured chordae tendineae.

Five patients with proved mitral insufficiency caused by ruptured chordae tendineae were examined. Two patients came to autopsy without cardiac cateterization. Three patients, who had cardiac cateterization and surgical replacement of their mitral valves, improved dramatically. Two additional patients have been clinically diagnosed and have had corroborative cardiac catheterization and are being observed in anticipation of possible future valve replacement. Similar findings in these seven patients include adult onset of a characteristic systolic heart murmur which mimics aortic valvular stenosis, acute pulmonary edema associated with massive mitral insufficiency in the face of a normal sized or only minimally enlarged left atrium, and variable size of the left ventricle. In none of the patients were there historical or physical findings of trauma or rheumatic or bacterial endocarditis. A wide spectrum of clinical courses may be explained by the variable number of ruptured chordae tendineae at the time of clinical presentation. Although the incidence and etiology are uncertain, we believe this entity is not uncommon. Myxomatous degeneration of the connective tissue of the heart was present, but the cause remains unknown.

Aged↗

PubMed1976

Transhepatic percutaneous cholangiography.

Transhepatic percutaneous cholangiography continues to be a significant tool in the diagnosis of jaundice. It allows direct, easily achieved graphic delineation of the biliary system. Although specific diagnosis may not be possible, the site and extent of obstruction and the differentiation from intrahepatic parenchymal disease may be determined with a high degree of success.

Adenocarcinoma↗

PubMed1972