Search PubMed⌕ Search

Biomedical subjects

E Buonocore

Publications and source records attributed to E Buonocore.

At least 37 records · Page 2Linked to original sources
PubMed1984

Digital subtraction angiography of the thoracic aorta.

Forty-three patients with acquired and congenital abnormalities of the thoracic aorta were studied using digital subtraction angiography (DSA) after an intravenous bolus injection of 40 ml of contrast material. Abnormalities studied included coarctation, pseudocoarctation, Marfan syndrome, cervical aorta, double aortic arch, aneurysm, dissection, and tumor. Twenty-four patients also had conventional angiography. DSA was accurate in 95% of cases; in the other 5%, involving patients with acute type I dissection, the coronary arteries could not be seen. The authors concluded that in 92% of their patients, DSA could have replaced the standard aortogram.

Adolescent↗
PubMed1984

Magnetic resonance of the chest: initial experience with imaging and in vivo T1 and T2 calculations.

Magnetic resonance (MR) imaging of the chest was performed in 33 patients; 28 patients had a variety of malignant tumors and five had benign processes involving the pleura, chest wall, mediastinum, hila , and pulmonary parenchyma. In addition, in vivo T1 and T2 calculations were performed on 17 malignancies and 2 benign processes. Of the 18 patients examined with both MR and computed tomography (CT), 15 MR examinations were considered to be as diagnostic as CT in demonstrating abnormalities. In two cases, CT was superior to MR. In one case without adequate vascular opacification on CT, MR was superior in differentiating a mass from pulmonary artery. It is concluded that, with current technology without respiratory or cardiac gating, MR offers little improvement in diagnosis over contrast-enhanced CT. Furthermore, it does not appear possible to predict tissue type based on T1 and T2 measurements because of a wide overlap in these values.

Carcinoma, Bronchogenic↗
PubMed1984

Clinical and in vitro magnetic resonance imaging of prostatic carcinoma.

Magnetic resonance imaging (MRI) of the prostate was accomplished in 10 patients who subsequently had surgical exploration for histologic confirmation and tumor staging. Eight patients were found to have carcinoma of the prostate. Two patients had malignancies of the urinary bladder and were treated with radical resection of the bladder and prostate. The prostatic glands in the latter two patients were free of tumor. One gland was entirely normal; the other had extensive acute and chronic prostatitis. Two resected prostates with carcinoma and one normal prostate were available for in vitro MRI in a clinical magnetic resonance unit. The MRI finding of prostatic carcinoma was heterogeneous signal patterns, seen best on T2-weighted studies. A similar pattern was identified in the gland with acute and chronic prostatitis. There was a homogeneous MRI signal pattern of the normal prostate gland examined in vitro. In two instances, the MRI studies were accurate for the identification of tumor spread to the seminal vesicles, not diagnosed at the time of surgical resection. Microscopic metastatic disease of the lymph nodes in four patients was not identified by MRI.

Adenocarcinoma↗
PubMed1983

Nuclear magnetic resonance (NMR) imaging in the evaluation of the liver: a preliminary experience.

To determine the usefulness of nuclear magnetic resonance (NMR) in evaluation of the liver, 19 examinations were performed. A variety of pathological conditions were examined, and correlation was obtained with computed tomography, ultrasound, and radionuclide liver/spleen scanning. Nuclear magnetic resonance was as sensitive as the correlating imaging modalities in the detection of focal disease. Parenchymal abnormalities could be detected only in hemochromatosis. Several patients with diffuse disease did demonstrate evidence of portal hypertension, but no characteristic findings were noted within the liver parenchyma. Our preliminary investigation did not include T1 and T2 values and it is hoped that these will allow greater diagnostic utility in the detection of diffuse parenchymal disease.

Hemochromatosis↗
PubMed1983

Anatomic and functional imaging of congenital heart disease with digital subtraction angiography.

Digital subtraction angiography (DSA) of the heart was performed in 54 patients for the evaluation of congenital heart disorders. DSA produced high-quality diagnostic images and accurate physiologic shunt data that compared favorably with catheter angiography and nuclear medicine studies. Retrospective analysis of this series of patients indicated that DSA studies contributed sufficient information to shorten significantly or modify cardiac catheterization in 85% (79/93) of the defects that were identified. Interatrial septal defects were particularly well diagnosed, with identification occurring in 10 of 10 cases, whereas intraventricular septal defects were identified in only 6 of 9 patients. Evaluation of postsurgical patients was accurate in 19 of 20 cases.

Adolescent↗
PubMed1983

Intravenous digital subtraction angiography: peripheral versus central injection of contrast material.

Central and peripheral intravenous injections of contrast material for digital subtraction angiography were compared in 30 patients. With 40 ml of contrast material, visualization of the carotid bifurcations was as good with the peripheral as with the central injection. A more consistently high-quality examination of the small intracranial vessels was obtained with the central injection.

Arm↗
PubMed1983

Digital subtraction angiography for preoperative evaluation of extremity tumors.

A retrospective study was undertaken to evaluate the role of digital subtraction angiography (DSA) in the surgical planning of musculoskeletal neoplasms. Thirteen patients with primary bone and soft-tissue tumors were examined by CT and DSA. Three patients also had conventional angiography. DSA yielded surgically useful information in 10 patients, comparable to that expected from conventional angiography. DSA was most helpful in demonstrating the presence or absence of major vessel involvement by tumor when this could not be ascertained definitely on CT. Demonstration of mass extent by CT was accurate in 11 patients. Results of this study suggest that the combination of CT and DSA is useful in the preoperative evaluation of selected extremity tumors and should diminish the need for conventional angiography.

Angiography↗
PubMed1983

NMR imaging of the abdomen: technical considerations.

Evaluation of nuclear magnetic resonance (NMR) imaging of the abdomen was done in 41 patients with focal and diffuse disorders of the liver and retroperitoneal and vascular abnormalities. Spin-echo technique was used in each situation with varying time to echo (TE) and repetition rates (TR). No single pulsing technique was optimal in all situations. Three false-negative NMR studies of 22 patients with focal lesions of the liver were attributed to incomplete coverage of the involved area or inappropriate pulsing technique. When appropriate technique was achieved, NMR was equal to computed tomography (CT) in detecting abdominal disorders, except in fatty infiltration of the liver. NMR was superior to CT in imaging vascular anatomy because of the inherent increased contrast produced by the absence of signal from flowing blood and the flexibility of imaging planes.

Abdomen↗
PubMed1982

Hepatic artery infusion with 5-fluorouracil and mitomycin-C in metastatic colorectal carcinoma phase II study.

Thirty-two patients with hepatic metastases colorectal carcinoma were treated with hepatic artery infusion (HAI) employing 5-fluorouracil (5-FU) and mitomycin-C (mito-C). Catheters were placed percutaneously via the femoral artery. Two schedules were employed: (I) 5-FU 1,200 mg/m2 IA (D1-4) and mito-C 8 mg/m2 IA (D1 + D4); (2) 5-FU 1,200 mg/m2 IA (D1-6) and mito-C 8 mg/m2 IA (D1 + D4). Courses were repeated every 4 weeks. Thirty patients with measurable disease were evaluable, 22 received schedule I and 8 patients schedule II. Complete response occurred in two patients (6.7%) and partial response in 13 patients (43.3%). Five patients (16.7%) had minimal regression. The overall response rate as 66.7%. Median survival of all patients from start of treatment was 11.2 months. Median survival of responders and nonresponders was 12.4 months and 4.6 months, respectively (P less than 0.05). No differences in response rates, duration of response, or survival was seen between the two schedules. Drug toxicity was moderate to severe, but morbidity of HAI per se was minimal. Intermittent HAI of 5-FU and mito-C is a well-tolerated treatment modality associated with few serious complications. The response rate, duration of response, and the survival is comparable to continuous HAI infusion of 5-FU or floxuridine (FUDR). As given in this study, mito-C did not appear to provide added benefit.

Adult↗