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Biomedical subjects

E Bos

Publications and source records attributed to E Bos.

At least 127 records · Page 7Linked to original sources
PubMed1989

Recognition of residual ventricular septal defect by intraoperative contrast echocardiography.

Intraoperative two-dimensional contrast echocardiography was used to detect a residual shunt in 50 patients after surgical repair of ventricular septal defect. Contrast injections were performed following termination of the extracorporeal circulation. In the presence of a shunt the intensity of opacification of both left and right ventricular cavities was compared. In 40 patients no ventricular shunting was observed; insignificant shunting was noted in five patients. Follow-up of these 45 patients proved uneventful. Significant opacification of the right ventricle was noted in five patients. This finding, however, does not necessarily indicate a residual shunt of significant volume. In two patients the residual shunt was confirmed postoperatively by pulsed Doppler echocardiography but clinically there was no need for surgery. Three other patients subsequently required reoperation and partial patch dehiscence was confirmed in all. Thus, intraoperative two-dimensional contrast echocardiography is a sensitive technique to detect a residual ventricular septal defect, an observation which may warrant reoperation before chest closure.

Child↗
PubMed1988

Treatment with cyclosporin and risks of graft rejection in male kidney and heart transplant recipients with non-O blood.

In a consecutive series of 146 kidney transplant recipients treated with cyclosporin A a strong correlation between matching for the HLA-A, HLA-B, and HLA-DR loci specificities and outcome of the grafts was observed in male recipients with non-O blood groups. Such a beneficial effect of matching was not found in female patients or male patients with blood group O. In these patients survival of the grafts at one year was good irrespective of the number of HLA-A, B, and DR mismatches. Also in 47 male heart transplant recipients immune responsiveness against mismatched HLA antigens was related to blood group. A significantly higher incidence of rejection episodes was observed in male patients with non-O blood groups (n = 32) than in those with blood group O (n = 15). Matching for HLA-DR reduced the number of acute rejection episodes in male patients with non-O blood. These findings may help explain the controversial reports about the importance of HLA matching in organ transplantation. Furthermore, as most candidates for heart transplantation are male and not of blood group O, the higher incidence of graft rejection in these patients underscores the need for an exchange strategy of donor hearts.

ABO Blood-Group System↗
PubMed1988

The role of intraoperative two-dimensional echocardiography in the assessment of thoracic aorta pathology.

The role of intraoperative two-dimensional echocardiography is discussed in 15 consecutive patients with thoracic aorta pathology undergoing cardiac surgery. A 5 MHz mechanical scanner was used before and immediately after cardiopulmonary bypass. In 5 patients intraoperative two-dimensional studies revealed crucial morphologic information which, consequently, had a marked influence on their planned surgical procedure. In 3 patients the findings provided additional information whereas in the remaining patients the intraoperative echocardiographic findings confirmed the preoperative diagnosis. Following surgery the adequacy of cardiac repair was assessed and, in one patient, epicardial echocardiography indicated the necessity for reoperation. The application of intraoperative two-dimensional echocardiography leads to a better understanding of the pathology involved and facilitates a more appropriate decision concerning the surgical procedure.

Adolescent↗
PubMed1988

The value of transoesophageal echocardiography for diagnosis of thoracic aorta pathology.

The potential of transoesophageal echocardiography for preoperative diagnosis of thoracic aorta pathology was evaluated in 15 patients with aortic dissection and 15 patients with aortic aneurysm. The transoesophageal echocardiographic findings were compared with 14 computed tomograms and 21 angiograms. Six patients underwent only transoesophageal echocardiography. All patients were operated upon and the surgical findings were used as a reference for these diagnostic methods. Transoesophageal echocardiography established a complete and correct diagnosis in 27 patients. The diagnosis was partially correct in three patients, all having an aortic dissection. A complete and correct diagnosis was obtained by computed tomography and angiography in 8 and 17 patients, respectively. The results indicated that transoesophageal echocardiography is a sensitive and convenient method for the definitive diagnosis of pathology of the thoracic aorta. It could become the technique of choice in patients suspected of having acute aorta pathology as it enables a rapid and definitive diagnosis at the bedside.

Adult↗
PubMed1988

Improvement in transient and 'persistent' perfusion defects on early and late post-exercise thallium-201 tomograms after coronary artery bypass grafting.

In order to assess the changes in the number and severity of transient and persistent myocardial perfusion defects before and after coronary artery bypass grafting (CABG), early and late post-exercise thallium-201 (tl-201) tomography was performed in 25 patients, on average 10 days before and 2.5 months after CABG. Six patients had a previous Q wave myocardial infarction. Comparing the pre- and post-CABG exercise test data (symptom limited bicycle ergometry) showed an improvement in working capacity (from 129 +/- 34 to 145 +/- 35 W, P less than 0.05) and a reduction in exercise induced angina from 77 to 9% of the patients (P less than 0.001). From the tomographic data, six short axis and three sagittal cross-sections of the left ventricular myocardium were reconstructed. In each patient study, a total of 51 myocardial segments were defined and analysed in a semi-quantitative manner by means of a five point scoring method indicative of the severity of a defect (from 0 = normal tl-201 uptake to 4 = absence of tl-201 activity). In this patient population the total number of segments with transient tl-201 perfusion defects decreased from 11.0 +/- 7 segments per patient (mean +/- SD) before surgery to 4.9 +/- 4 after surgery (P less than 0.01); the number of segments with 'persistent' tl-201 defects decreased as well, from 7.5 +/- 6 to 3.9 +/- 4 segments per patient (P less than 0.03).(ABSTRACT TRUNCATED AT 250 WORDS)

Coronary Artery Bypass↗
PubMed1988

Saccular aneurysm of the transverse thoracic aorta detected by transesophageal echocardiography.

A patient with a saccular aneurysm of the thoracic aortic arch presented with severe right ventricular failure due to pulmonary artery compression. Contradictory data were derived from computed tomography, pulmonary isotope perfusion scan and cardiac catheterization. Transesophageal echocardiography revealed a saccular aneurysm which compressed the main pulmonary artery and gave access to a fistulous connection to the left pulmonary artery. Surgery confirmed these findings.

Aorta, Thoracic↗
PubMed1987

Intraoperative two-dimensional echocardiography in congenital heart disease.

Intraoperative epicardial two-dimensional echocardiography was used in 195 patients undergoing surgery for congenital heart disease to evaluate its potential to identify new diagnostic information immediately before and after surgical correction. In 168 patients the preoperative diagnosis was confirmed by intraoperative echocardiography. In four patients, unsuspected findings were revealed, which resulted in modification of the surgical approach. In 18 patients additional morphologic information was obtained which contributed to alteration or refinement of surgical management. The adequacy of cardiac repair was assessed before closure of the chest in all patients. In six patients this information led to immediate reoperation and in four other patients to inotropic drug therapy. During congenital heart surgery, epicardial two-dimensional echocardiography may yield important information for surgical management. The technique is an essential adjunct when preoperative diagnostic studies are not conclusive or when the initial response to repair is unsatisfactory.

Adolescent↗
PubMed1987

Value of the regurgitant volume to end diastolic volume ratio to predict the regression of left ventricular dimensions after valve replacement in aortic insufficiency.

The aim of this study was to assess the value of regurgitant stroke volume (RSV) to end-diastolic volume (EDV) ratio to predict the regression of left ventricular (LV) dimensions after uncomplicated valve replacement in 34 patients with severe pure aortic insufficiency. The RSV/EDV ratio was measured by contrast ventriculography and thermodilution techniques. LV end-diastolic diameter (EDD) was measured pre- and postoperatively by M-mode echocardiography (at a median interval of 3.3 years after valve replacement). LV/EDD decreased from 74 +/- 8 mm to 54 +/- 11 mm (P less than 0.001). Eleven patients had a persistent postoperative LV enlargement (median EDD 65 mm, range 56-100 mm) while, in 23 patients, EDD became normal (median 49 mm, range 40-55 mm). During follow-up, one patient with LV enlargement died of congestive heart failure. Preoperative RSV/EDV ratio was significantly higher in patients with normal postoperative EDD as compared to those with persistent LV enlargement (0.32 +/- 0.06 vs. 0.24 +/- 0.07, P less than 0.005). The best cutoff point of RSV/EDV to predict the normalization of LV dimensions was 0.28. Postoperative EDD remained abnormal in eight out of 16 patients (50%) with RSV/EDV ratio less than 0.29, while it remained enlarged in only three out of 18 patients (17%) with a preoperative RV/EDV ratio greater than 0.28. The other usual preoperative catheterization and echocardiographic variables were equally or less predictive than RSV/EDV ratio. In conclusion, despite the limitations due to the use of different techniques, we confirmed that the RSV/EDV ratio is a potentially useful variable for the assessment of the proper timing of valve replacement in patients with severe isolated aortic insufficiency.

Adolescent↗
PubMed1987

Survival at 5 to 10 years after aorto-coronary bypass operations in 1041 consecutive patients.

To evaluate longterm survival, 1041 consecutive patients with aorto-coronary bypass operations were followed for a mean of 7.5 years (range 5 to 14.5). The peri-operative mortality was 12 (1.2%). Of the 131 late deaths, 97 (74%) were cardiac in origin. The survival probability at 5 years was 92 +/- 2% and at 10 years 79 +/- 4%. Figures for a matched general Dutch population are 94% and 87%, respectively. Stepwise multivariate analysis revealed an association between death rate and impaired left ventricular function (rate ratio impaired function versus normal: 1.82, P = 0.0007) and extent of vascular disease (rate ratio 3 vessel-versus 1 vessel disease: 1.80, P = 0.01) while no relation was found with sex or age at operation. Surgery seems to provide a good probability of survival, although in patients with extensive vascular involvement and/or a decreased left ventricular function at the time of operation, the longterm outlook is less favourable than for those without these characteristics.

Angina Pectoris↗
PubMed1987

Early cardiac valve replacement in infective endocarditis: a 10-year experience.

Thirty one patients underwent early valve replacement for infective endocarditis during a 10-year period (between September 1973 and December 1983). Intractable heart failure, persistent infection and systemic emboli were the indications for urgent surgical intervention. Native valve endocarditis had been present in 22 patients (71%) and surgery was performed 14-105 (mean 51) days after the onset of symptoms. Nine patients (29%) had prosthetic valve endocarditis and surgery was performed within 6 to 51 (mean 28) days. The aortic valve was replaced in 22 patients (71%), the mitral valve in 5 patients (16%) and both valves in 4 patients (13%). Four patients (12.9%) died during hospitalization. There were no late deaths or reinfection in this series. The remaining 27 patients were discharged and after a mean follow-up period of 36 months, 25 patients were in NYHA functional class I or II. Only 9 patients (29%) underwent cardiac catheterization prior to surgery and the other patients were operated upon on the basis of echocardiographic data alone. The post-operative results with a survival rate of 87%, justify an aggressive surgical approach in order to prevent serious complications and cardiovascular deterioration. It appears that surgical decision-making can be made on the basis of echocardiography. The risk of cardiac catheterization can be avoided with the newer generation of echocardiographic equipment which allows a detailed and complete analysis of cardiac abnormalities and function.

Adolescent↗
PubMed1987

Incidence, risk, and outcome of reintervention after aortocoronary bypass surgery.

Reintervention was required in 123 (12%) individuals during a follow up (mean 7.5 years, range 5-14.5) of 1041 patients with consecutive, isolated, first aortocoronary bypass operations. In 89 patients the intervention was a repeat bypass operation, in 24 it was angioplasty, and 10 had both. Procedure related mortality was significantly higher at reintervention (5.6%) than at the primary operation (1.2%). Survival probability after a single bypass procedure was 90% at six years and 82(3)% at nine years. Corresponding figures six and nine years after reintervention were 89(6)% and 87(7)% respectively. Stepwise multivariate analysis showed that survival was significantly correlated with left ventricular function (rate ratio 1.82) and with extent of vascular disease (rate ratio 1.80) but not with reintervention (rate ratio 1.45). Symptomatic improvement occurred in 89% of the survivors with or without reintervention. Repeat procedures are often necessary after coronary artery bypass grafting but they appear to provide appreciable relief of symptoms without reducing any long term improvement in survival brought about by the original operation.

Adult↗