Methylation of DNA in HeLa cells after ultraviolet irradiation.
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DNA↗
Biomedical subjects
E Borek
Publications and source records attributed to E Borek.
Elevated urinary excretion of beta-aminoisobutyric acid and exposure to inorganic lead.
beta-Aminoisobutyric acid (beta-AIB), a normal degradation product of thymine, a constituent of DNA and, to a lesser extent, of transfer RNA, is excreted in low levels in human urine. We found that a group of iron workers occupationally exposed to inorganic lead excreted high levels of urinary beta-AIB. Elevated urinary excretion of beta-AIB was also observed in marmosets, Callithrix jacchus, that received lead acetate in drinking water. Our results suggest that increased urinary excretion of beta-AIB could stem from damage to DNA on exposure to lead.
Adult↗
Regulation of the tRNA methylases.
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Animals↗