Biomedical subjects

E Bodiguel

Publications and source records attributed to E Bodiguel.

4 recordsLinked to original sources

PubMed1992

[Antiphospholipid antibodies and the central nervous system].

Among anti-phospholipid antibodies (APA), anti-cardiolipin antibodies and lupus anticoagulants are associated with arterial and venous thrombo-embolic manifestations. Antiphospholipid antibodies can be secondary to numerous diseases, especially systemic diseases, but they are usually encountered in the primary antiphospholipid syndrome. Neurological manifestations associated with APA are most often, if not always, ischemic in nature: large or small subcortical, often multiple, infarcts and transient ischemic attacks are the usual clinical presentations. Several mechanisms can lead to cerebral ischemia in the primary antiphospholipid syndrome, and their diagnosis is probably important for therapeutic choices. A prospective controlled study has started, which should provide data on the prognosis and management of this syndrome.

Antibodies, Antiphospholipid↗

PubMed1992

[Cerebral infarction, placoid epitheliopathy and sarcoidosis].

We report a case of cerebral infarction in the basal territory of the left middle cerebral artery, associated with acute posterior multifocal placoid pigment epitheliopathy, most probably due to sarcoidosis. Neurological symptoms resolved spontaneously without sequelae. We discuss the relationship between acute posterior multifocal placoid pigment epitheliopathy, sarcoidosis and cerebral granulomatous angiitis.

Adult↗

PubMed1990

[Complex temporal partial status epilepticus].

The cases of non convulsive, complex, partial ailment are a cause of a confusional state. Such a case on an adult is here reported, and its clinical presentation was a unvarying forgetfulness together with elements of a frontal syndrome. The aetiology was most probably a viral meningo-encephalitis. Clinical semiology of these "EMPC" is variable, either made of partial, recurrent attacks, sometimes with automatisms, or made of a continuous, possibly fluctuating, confusional state. Attacks shown on the EEG are partial or generalized with a variable start, sometimes bilateral, even continuous or discontinuous. The onset is most often temporal or frontal. The cause is very rarely found out. The evolution is usually good, but extended deficiencies of memory are described, linked to the duration (more than 12 hours) of EMPC. Therefore, the treatment must be precocious using diazepam or phenytoin.

Encephalitis, Arbovirus↗

PubMed1990

[Magnetic resonance imaging after a one-month interval of lesions of multiple sclerosis in 2 populations, one during an acute attack treated with methylprednisolone, the other stable with no treatment].

Changes in clinical symptoms and MRI lesions of multiple sclerosis (MS) were evaluated on two occasions, one month apart, in 30 patients. Seventeen patients (group 1) with acute exacerbation were treated with methylprednisolone in high, then decreasing doses during a total of 30 days. MRI examinations were performed before and at the end of treatment. The remaining 13 patients (group 2) had been clinically stable for more than 6 months and received no treatment; here again, MRI was performed at 30 days' interval. All patients in group 1 showed functional improvement. The MRI lesions remained stable in 7 of group 1 patients and in 4 of group 2 patients. In the remaining 19 patients (10 in group 1 and 9 in group 2), the number, size and location of MRI lesions were found to have changed over 1 month. There was no correlation between clinical changes and the modification observed at MRI. This study confirms that high-dose corticosteroids are effective, at least clinically, in acute exacerbations, but the main results are that MS is a continually evolving disease, that changes rapidly occur in the lesions observed at MRI and that corticosteroids do not seem to influence the course of MRI lesions. Our study also suggests that MRI is inadequate to evaluate the effectiveness of short-time treatments of MS.

Follow-Up Studies↗