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Biomedical subjects

E Bingen

Publications and source records attributed to E Bingen.

At least 199 records · Page 11Linked to original sources
PubMed1983

[Rapid diagnosis of pathogenic bacteria isolated from stool cultures by a standardized micromethod].

We evaluate a new and quick micromethod which detect strains of Salmonella, Shigella and Yersinia from suspected colonies isolated of stool specimens. In our study, from 2 384 non pathogen bacteria or as Salmonella. And we determined 297 strains of Salmonella, two hours after isolation on selective medium. This method is very easy and permits to have a rapid diagnostic of strains of Salmonella.

Bacteria↗
PubMed1983

Bacteriological analysis of jejunostomy fluid after surgery for extrahepatic biliary atresia.

Quantitative cultures were made of jejunostomy fluid from 22 children with extrahepatic biliary atresia following hepatoportoenterostomy. Bacterial flora characteristics did not differ in patients with or without cholangitis. With the exception of Streptococcus group D, the most frequently encountered bacterial species with the highest mean concentrations in the jejunostomy fluid, were those mostly responsible for cholangitis (Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa). In 19 of 22 acute episodes, the organism causing cholangitis identified in blood and/or liver was also isolated from jejunostomy fluid. However, quantitative determinations in this fluid did not permit reliable identification of this organism. When the same bacterium caused early relapse, it often persisted in the jejunostomy fluid.

Bacterial Infections↗
PubMed1982

[Determination of biotypes of the genus Haemophilus and study of the sensitivity to ampicillin in hospital practice. Study of 500 strains].

The authors use a biologic micromethod to identify five hundred species and biotypes of Haemophilus strains isolated from clinical specimens. The relation between biotypes and infection is studied. A rapid and highly accurate test to search for beta-lactamase production is done to determined the actual ampicillin resistance in Haemophilus for different biotypes. 6.9 p. cent of Haemophilus influenzae and 17.5 p. cent of Haemophilus para-influenzae were found resistant to ampicillin.

Ampicillin↗
PubMed1982

[Relevance and applications of systematic quantitative determinations of gentamicin during the neonatal period (author's transl)].

We have used an enzyme immunoassay method to measure serum levels of gentamicin in neonates according to gestational age, birth weight, dosage and intervals of intramuscular injections. Peak, predose serum levels and half-life decrease when gestational age increase. For the same gestational age, peak serum levels decrease in small weight neonates. Toxic postdose serum levels were obtained in preterm neonates with a daily regimen exceeding 5 mg/kg. Serum concentration monitoring of gentamicin is recommended to ensure adequate dosage and interval of injections.

Bacterial Infections↗
PubMed1982

[Bacteriological study in acute otitis media].

A retrospective study was conducted of 587 bacteriological samples collected from 387 children with acute otitis media treated as outpatients over a period of 30 months, to determine relative frequency of the causative germs and their resistance to antibiotics. The most frequently involved bacteria were staphylococci (16 p.cent) of which 70 p.cent were Staph. Epidermidis, and Haemophilus (17 p.cent), résistance to ampicillin being present in 19 p.cent. These results, which differ from those in the published literature, suggest that paracentesis with systematic bacteriological typing is the treatment of choice in acute otitis media.

Acute Disease↗
PubMed1981

[Effects of cefotaxime on the intestinal bacterial ecosystem in children (author's transl)].

Cefotaxime activity was studied in pediatric practice on the intestinal bacteria flora of 10 children, by means of a differential quantitative method for aerobic and anaerobic faecal flora and was compared to that of 41 controls not receiving any antibiotics. Cefotaxime was given alone in 7 children, and in combination with gentamicin in 3. An effect on the intestinal bacterial flora was noted on E. coli, which disappeared in 4 cases and diminished considerably in 5. A slight increase in Streptococcus D was observed without excessive multiplication of the flora. The study showed no significant alteration for the other aerobic or anaerobic bacilli. There was no selection of resistant organisms. Cefotaxime is a new cephalosporin which does not seem to produce an increase in many resistant pathogens due to a break-down of the barrier effect observed on the bacterial flora of the gut in children.

Cefotaxime↗
PubMed1981

[Cefotaxime and Gram-negative infections in children. Effectiveness and tolerance (author's transl)].

Twenty-six children, aged from 15 days to 14 years, were treated with cefotaxime. 5 were suffering from septicaemia, 14 from respiratory tract infection and were ventilated (intensive care unit), 4 from urinary tract infection and 3 from otitis media complicated with renal failure (nephrology unit). The choice of cefotaxime treatment was based upon the bacterial activity. The daily dose was 50 to 100 mg/kg by the i.m. route, or by slow intravenous injection every 8 hours. In 17 patients, cefotaxime was combined with an aminoglycoside (gentamicin or amikacin). The results were evaluated on the basis of clinical, radiological and bacteriological criteria and, whenever possible, were correlated to the serum levels of antibiotic. The antibiotic was clinically effective in 25 out of 26 patients. The three deaths that occurred, were due to the nature of the initial disease. Tolerance was good in all the patients studied. The efficacy of cefotaxime correlated well with the favorable in vitro bacteriological results and with serum concentrations. Cefotaxime is well tolerated as shown in newborn babies. Cefotaxime is markedly different from previous cephalosporins, because of its high antibacterial activity on most Gram-negative bacilli.

Adolescent↗
PubMed1981

[The child's intestinal ecosystem: effect of colistin (author's transl)].

A differential quantitative study of the fecal flora was used to appreciated the intestinal bacterial flora of 41 hospitalized children, with no infection and receiving no antibiotic treatment. Thus, it was possible to establish the bacterial normal profile of intestinal of hospitalized child. Because of the stability of the fecal flora in those controls, it was possible to study the effect of colistin on the intestinal ecosystem, in 21 children. Colistin per os, with intestinal nutrition and colistin IM in combination with gentamicin IM did not have any quantitative or qualitative effect on fecal flora. Colistin per os, with exclusive parenteral nutrition caused by disappearance of sensitive strains and their replacement by resistant organisms; this was followed by secondary septicaemia. This fact being a very high infectious risk, it leads us to abstain from administering colistin per os, when the intestine does not receive any food.

Administration, Oral↗
PubMed1978

[Antibiotic therapy, intestinal microbial pullulation and risk of infection in children].

The effect of antibiotic therapy on the intestinal flora was studied qualitatively and quantitatively in 41 infants. The results have been compared with 27 normal children of the same age and background. Antibiotics were responsible for the suppression of sensitive strains and for their replacement by resistant organisms but above all to a rapid multiplication of the intestinal flora. Colistin and pristinamycin caused these changes when given orally. Ampicillin when given both orally and parenterally but Colistin and the aminoglycosides when given parenterally did not have any effect. Fourteen cases of secondary septicaemia due to resistant organisms were observed but other factors were also important, namely the young age of the patients and intestinal problems (stasis and diarrhoea).

Age Factors↗