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Biomedical subjects

E Benhamou

Publications and source records attributed to E Benhamou.

102 records · Page 6Linked to original sources
PubMed1981

Randomised placebo-controlled trial of hepatitis B surface antigen vaccine in french haemodialysis units: II, Haemodialysis patients.

A vaccine against hepatitis B surface antigen (Institut Pasteur Production) was assessed in 138 haemodialysis patients in a placebo-controlled randomised double-blind trial. In an interim analysis, hepatitis B infections were observed in 21% of the vaccine group and 45% of the placebo group (p less than 0.02). 2 of the infections in the vaccine group and 12 of the infections in the placebo group occurred after the third injection. 60% of the vaccine recipients had an immune response. 4 months after the first injection the mean titre of anti-HBs was 120 mlU/ml.

Adult↗
PubMed1981

Randomised placebo-controlled trial of hepatitis B surface antigen vaccine in French haemodialysis units: I, Medical staff.

A vaccine against hepatitis B surface antigen (Institut Pasteur Production) was assessed in staff members from forty-eight French haemodialysis units where the risk of hepatitis B was high. Of 318 subjects who completed the protocol, 164 received three monthly injections of vaccine and 154 received corresponding injections of placebo. Hepatitis B infection was observed in 3.6% of the vaccine group and 12.3% of the placebo group (p less than 0.005). The 6 infections in the vaccine group all arose within 63 days from the first injections, whereas the 19 in the placebo group arose throughout the 12 months of follow-up. The rate of side-effects after injection did not differ in the two groups. 94% of the vaccine recipients had an immune response ( greater than 10 mIU/ml in at least 5 successive specimens). 4 months after the first injection the mean + or - 2 SE peak level of anti-HBs was 2433 + or - 1077 mIU/ml.

Clinical Trials as Topic↗
PubMedDate not supplied

Prevention of gram-positive infections in patients treated with high-dose chemotherapy and bone marrow transplantation: a randomized controlled trial of vancomycin.

Between January 1986 and June 1988, 155 patients (73 children and 82 adults), who were candidates for bone marrow transplantation, were included in a randomized controlled trial (75 patients in vancomycin group and 80 patients in the group without vancomycin) to evaluate the efficiency of a short course of vancomycin (10 mg/kg i.v. every 6 hours, day-5 to +1) in decreasing the incidence of Gram-positive infections during aplasia after high-dose chemotherapy and bone marrow transplantation. There was no statistical difference in the occurrence of documented septicemia, documented coccus Gram-positive infections, or fever of unknown origins during aplasia in the 2 groups. Thus, short prophylactic treatment with vancomycin proved inefficient in reducing morbidity due to infection after high-dose chemotherapy and bone marrow transplantation.

Adult↗
PubMedDate not supplied

Magnetic resonance imaging in retinoblastoma and retinocytoma: a case report.

Magnetic resonance imaging (MRI) is playing a growing role in the evaluation of ocular and orbital tumors. We report the case of a 26-month-old child presenting an undifferentiated retinoblastoma with a differentiated retinocytoma component in his left eye. After the eye was enucleated, we could correlate the clinicopathologic findings with the MRI scans. Both the undifferentiated retinoblastoma and the differentiated retinocytoma components could be determined on magnetic resonance imaging. Because different levels of metabolic activity within a tumor mass may influence largely T1 and T2 parameters, accurate determination of these values may be useful in determining the differentiation of a retinoblastoma, enabling a better therapeutic approach and assessment of the response to treatment.

Child, Preschool↗
PubMedDate not supplied

[Mortality from cancer in France. Changes between 1950 and 1989 in the population aged 35-64].

In the French population aged 35-64, cancer mortality increased yearly by 1 percent in males and decreased yearly by 0.6 percent in females between 1950 and 1989. In males, the increase is mostly due to the sites associated with tobacco and alcohol. The important increase of lung cancer is related to the increase in tobacco consumption from 4.7 g per adult per day in 1950 to 6.3 g in 1976. The increase observed in head and neck cancers is related to tobacco and alcohol. In females, the moderate decrease is due to the decrease observed in uterine cervix and stomach cancer mortality, uncompensated by the increase in breast cancer. Contrary to what is observed in the USA, there is no marked increase in lung cancer mortality for women.

Adult↗