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Biomedical subjects

E Bengtsson

Publications and source records attributed to E Bengtsson.

At least 109 records · Page 6Linked to original sources
PubMed1977

A 13-year follow-up of antimony-treated Schistosoma mansoni-infected patients.

Thirty consecutive patients who were treated for Schistosoma mansoni infection with antimony sodium dimercaptosuccinate (Astiban) during the 1960s, and who had not visited an endemic area since the treatment, were reexamined 11 to 17 (average 13) years after the last presumed exposure. Seven of them (23%) still had active infections, six being chronic infections of which only one had been treated in an acute stage. None of the patients with chronic S. mansoni infection had signs of changes in liver, gut, or other organs, and all were able to work at full capacity. Living eggs were found in rectal biopsy specimens from all cases, but in only two cases in stool specimens. Serological reactions were positive in three cases and also in two of the egg-negative cases. Skin tests gave immediate positive reactions in 6 of 7 egg-positive and in 11 of 23 egg-negative patients.

Adult↗
PubMed1977

Interaction of adrenergic agents with alpha-melanocyte-stimulating hormone and infrared irradiation of the iris in the rabbit eye.

Breakdown of the blood aqueous barrier in the rabbit eye induces a protein leakage into the aqueous humor, seen as a flare in the anterior chamber. A barrier damage was induced by topical prostaglandin E2(PGE2), infrared irradiation of the iris, or alpha-melanocyte-stimulating hormone (alpha-MSH) given subcutaneously. The aqueous flare was measured quantitatively by means of a photoelectric instrument. The interference of adrenergic antagonists and agonists on the breakdown of the barrier was tested. The alpha-adrenergic antagonist phentolamine and the beta-adrenergic antagonist propranolol, given intravenously, had no effect on exogenously administered PGE2, but both antagonists reduced the flare response to infrared irradiation which is supposed to exert its effect via endogenous prostaglandin release. The alpha-MSH response was unaffected by phentolamine, whereas propranolol abolished the flare response to alpha-MSH totally. The PGE1 response was unaffected both by the alpha-adrenergic agonist noradrenaline and the beta-adrenergic agonist terbutalin sulfate, administered topically. Noradrenaline, however, inhibited the flare response to infrared irradiation and facilitated the flare response to alpha-MSH. Terbutalin sulfate worked synergistically with both infrared irradiation and alpha-MSH. It is assumed that alpha-MSH exerts its effect on the barrier via enhanced beta-adrenergic activity, whereas the effects caused by infrared irradiation seem conditioned by intact alpha- as well as beta-adrnergic receptor sites.

Animals↗
PubMed1977

The effect of theophylline on the breakdown of the blood-aqueous barrier in the rabbit eye.

A disruption of the blood-aqueous barrier in rabbit eyes was elicited by topical prostaglandin E2, infrared irradiation of the iris, or subcutaneous alpha-melanocyte stimulating hormone (alpha-MSH). The course of the inflammatory reaction was followed by photoelectrical measurements of the aqueous flare in the anterior chamber. Pretreatment with intravenous theophylline, a phosphodiesterase inhibitor, significantly increased the protein leakage caused by prostaglandin E2 and alpha-MSH, but the response to infrared irradiation was slightly but not significantly enhanced. Intravenous theophylline given in higher doses caused per se an aqueous flare increase, which could not be inhibited by pretreatment with topical indomethacin. Our results indirectly indicate that accumulation of intraocular cAMP promotes a barrier damage and that cAMP might be the common effector of the barrier breakdown caused by prostaglandin as well as by nonprostaglandin agents.

Animals↗
PubMed1976

SCANCANS--an interactive scanning cell analysis system.

This paper describes a computerized, general-purpose, interactive, scanning cell-analysis system developed at the Department of Clinical Cytology of the University Hospital in Uppsala. The system uses a Leitz MPV II scanning photometer, a PDP-8 computer with 24 k of core memory and a Tektronix 4010 graphic display terminal. A command interpreter and overlay structure which makes it simple to add new capabilities to the system is described. Some examples of command strings and the kind of operations the system can perform are included. Finally, the experience gained from using the system and some plans for future extensions are discussed.

Autoanalysis↗
PubMed1976

A microspectrophotometric study of Papanicolaou-stained cervical cells as an aid in computerized image processing.

As part of a study of cytologic automation, microspectrophotometric investigation of Papanicolaou-stained cervical cells was performed, using a Leitz MPV-II scanning photometer connected to a PDP 8/F minicomputer. It was shown that the selection of one single wavelength may result in difficulties in detecting boundries between background and cytoplasm and/or between cytoplasm nucleus. A set of two wavelengths, 530 nm and 570 nm, were found to be optimal for the image processing of these cells.

Cell Nucleus↗
PubMed1976

Hearing loss as a sequel to chloramphenicol and ampicillin treatment of Haemophilus influenzae meningitis.

20 patients with Haemophilus influenzae meningitis who had been treated with chloramphenicol over the period 1959-1970 and 23 patients who had been treated with ampicillin over the period 1968-1974 were re-examined by hearing tests in 1975. In all the cases the two agents had been given initially by the parenteral route, chloramphenicol in doses varying between 50 and 150 (averaging 101) mg/kg/day and ampicillin in doses varying between 125 and 350 (averaging 229) mg/kg/day. Five of the 20 patients in the chloramphenicol group were found to be deaf on one ear, whereas 1 of the 23 patients in the ampicillin group was completely deaf. A further 3 in the chloramphenicol group and 1 in the ampicillin group had slight sensorineural hearing loss on one ear. Only in 2 of the 6 deaf patients was the loss discovered during the time of hospital care. The present study has not provided any evidence supporting the recently reported observation (Gamstorp and Klockhoff, 1974) that the frequency of hearing loss might be higher after ampicillin than after chloramphenicol treatment for H. influenzae meningitis.

Adolescent↗
PubMed1976

The effect of imidazole on the disruption of the blood-aqueous barrier in the rabbit eye.

The aqueous flare (AF) of an intact rabbit eye was measured by a photoelectrical instrument and the intraocular pressure by vibration tonometry. Prior treatment with imidazole given intraperitoneally noticeably inhibited the disruption of the blood-aqueous barrier in rabbit eyes induced by topical prostaglandin E2 (PGE)2, topical arachidonic acid (AA), infrared irradiation of the iris, endotoxin of Proteus mirabilis given intravenously, and alpha-melanocyte-stimulating hormone (alpha-MSH) given subcutaneously. Prior treatment with imidazole given topically had no effect on the disruption of the blood aqueous barrier caused by topical PGE2, topical AA, infrared irradiation of the iris, or endotoxin of P. mirabilis given intravenously, but facilitated and potentiated strongly the response to alpha-MSH given subcutaneously. Prior treatment with topical imidazole did not affect the histological changes of the anterior ciliary processes induced by alpha-MSH given subcutaneously.

Administration, Topical↗