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Biomedical subjects

E Beck

Publications and source records attributed to E Beck.

At least 217 records · Page 12Linked to original sources
PubMed1977

Liver and spleen scanning as a useful diagnostic test in the management of liver trauma in young patients.

Liver and spleen scanning is a safe, fast and noninvasive diagnostic procedure. With the advent of mobile Gamma Cameras it can be ideally performed in a casualty department. The number of patients with traumatic blunt injuries to the abdomen is increasing and in correlation with the increased speed and concentration of traffic. In eleven patients with ages ranging between 4 and 23, and under observation for violent trauma to the abdomen, liver and spleen scanning was performed either as an emergency procedure or as a follow-up study. Very useful information was obtained regarding the integrety of these organs, before and or after emergency surgical treatment.

Abdominal Injuries↗
PubMed1977

Oxygen Concentration in Isolated Chloroplasts during Photosynthesis.

The O(2) concentration in intact and osmotically disrupted isolated spinach (Spinacia oleracea, L.) chloroplasts during photosynthesis was estimated. The chloroplasts were allowed to reduce 3-phosphoglycerate, CO(2), or ferricyanide in light until the rate of O(2) production was linear. When the light was turned off O(2) evolution from the chloroplasts continued for a few seconds. This prolonged O(2) evolution is due to an O(2) surplus inside the chloroplasts which equilibrates with that in the medium. From this surplus the O(2) concentration inside the chloroplasts at the moment when the light had been switched off was calculated. In all experiments the O(2) concentration inside the photosynthesizing chloroplasts was higher than that outside, but was dependent upon the O(2) concentration of the chloroplast medium. At low external O(2) concentration (30 mum) the ratio of the internal to the external O(2) concentration was about 5, whereas at concentrations corresponding to those in airsaturated water this ratio was close to 1. With osmotically broken chloroplasts this ratio was 1.2 at 30 mum O(2) and almost 1 from 150 mum onward. When the O(2) surplus found in broken chloroplasts during photosynthesis was related to the volume of the thylakoids, a ratio of about 2.3 was observed.

Journal Article↗
PubMed1976

Kuru.

Explore the source record for details and available documents.

Animals↗
PubMed1975

Experimental kuru in the spider monkey. Histopathological and ultrastructural studies of the brain during early stages of incubation.

The brains of 10 spider monkeys inoculated intracerebrally with brain suspension from kuru patients have been studied histologically and ultrastructurally. The animals were killed by perfusion of fixative from four to forty-one weeks after inoculation, when healthy and free of neurological signs. Definite histopathological changes had occurred as early as four weeks after inoculation, when moderate numbers of bi-nucleated neurons were found within the limbic cortex, striatum, the hypothalamus and amongst the Purkinje cells of the cerebellum. At later stages of incubation a moderate loss of neurons in the cerebral and cerebellar cortex and a mild to moderate proliferation of fibrous astrocytes here and also in the hypothalamus were the most striking features. None of our cases showed either status spongiosus or the generalized astrocytic proliferation and hypertrophy, characteristic of fully developed experimental kuru, in any region of the brain. The principal ultrastructural abnormalities consisted of the formation of membrane-bound intracytoplasmic vacuoles, predominantly within dendrites, and of concentric laminar arrays derived from the endoplasmic reticulum. The former were seen in all regions of the brain examined and at all stages of incubation. Concentric laminar arrays were confined to the cerebellar nodulus, where they were most numerous in dendrites and neuronal perikarya four weeks after inoculation. Both changes are interpreted as an indication that the kuru agent acts upon the plasma membrane from an early stage onwards and, by stimulating its growth, leads to the formation of complex, membrane-bounded vacuoles and to hyperplasia of the endoplasmic reticulum. The formation of vacuoles is further regarded as the first sign of status spongiosus on an ultrastructural level. Attention is drawn to the great similarities between the changes observed in the present material and those described in the brains of patients dying from kuru and of primates with fully developed experimental kuru. The significance of the relatively rapid spread of the kuru agent throughout the brain is discussed in relation to the concept of "slow virus" diseases.

Animals↗