Adenovirus gastroenteritis.
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Adenoviridae Infections↗
Biomedical subjects
E Baskin
Publications and source records attributed to E Baskin.
Increased neutrophil apoptosis during attacks of familial Mediterranean fever.
AIM: Apoptosis is a programmed form of cell death. Recently much attention has been devoted to the role of apoptosis in rheumatological diseases. We have aimed to analyze apoptosis in the inflammatory pathway of familial Mediterranean fever (FMF). METHODS: 26 FMF patients and 12 age and sex matched controls were the subject of the study. Twelve of the patients were analyzed during an FMF attack whereas samples were obtained at least a week after an attack in 14. Four of the patients had renal amyloidosis. Whole blood was treated with ammonium chloride for RBC lysis. Subsequently the cells were stained with propidium iodide and annexin. Neutrophils and lymphocytes were gated separately for analysis by flow cytometry. We have also analyzed cellular Fas and Fas-ligand expression in these cells. RESULTS: The mean age of the patients was 12.00 +/- 3.17, and was not different than the control subjects. Erythrocyte sedimentation rate and CRP levels were significantly elevated in the attack group as compared to the attack-free group. The mean levels of neutrophil apoptosis in the FMF patients with an attack, attack-free and controls were 12.94 +/- 11.78, 6.60 +/- 7.83 and 3.98 +/- 4.27, respectively. Lymphocyte apoptosis in the same groups were 7.84 +/- 8.63, 2.75 +/- 2.33, and 1.22 +/- 0.93, respectively. Neutrophil and monocyte apoptosis was significantly increased during the attack as compared to the controls (p < 0.05). However lymphocyte apoptosis was not different between the aforementioned groups. On the other hand, lymphocyte apoptosis was significantly increased in the SLE patients (p < 0.05), whereas neutrophil apoptosis was not. Fas staining of neutrophils were not different between the groups (p > 0.05). On the other hand the difference between the groups for FasL was significant (p < 0.05). CONCLUSION: Neutrophil and monocyte but not lymphocyte apoptosis was significantly increased during FMF attacks reminding us that FMF is an autoinflammation of certain peripheral cells. The increased apoptosis in these patients maybe regarded as a response to clear the unwanted inflammatory cells. On the other hand the increased apoptosis maybe the explanation of the self-limited nature of the FMF attacks. Future studies will enlighten us on the significance of this increased apoptosis in the process of inflammation.
Adolescent↗
Epithelial cell-derived neutrophil activator-78 levels in children with familial Mediterranean fever.
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Adolescent↗
A pregnant woman with Ebstein's anomaly. A case report.
Ebstein's anomaly is characterised by downward displacement of the tricuspid valve into the right ventricle. The most deformed leaflets are the septal and mural ones. The abnormally situated tricuspid orifice produces a portion of the right ventricle lying between the atrioventricular ring and the origin of the valve. This proximal segment is atrialized. Commonly associated anatomical defects include a atrial septal second defect, a ventricular septal defect, pulmonary stenosis or atresia, and mitral valve prolapse. An accessory conduction pathway (Wolf-Parkinson White syndrome) was found in this malformation. It is thought that this malformation is due to a direct teratogenic effect of lithium on the atrioventricular junction. Ebstein's anomaly can be accurately identified by echocardiography and angiography.
Adult↗
Perforated duodenal ulcer: an unusual complication of meningitis.
An 11-month-old boy was admitted to the hospital with fever, vomiting and seizures and was diagnosed with purulent meningitis. Two days later, an acute, perforated, duodenal ulcer was detected in the patient. Surgery was performed, and the patient made an uncomplicated recovery. Peptic ulceration is underdiagnosed in children and this leads to delay in diagnosis and appropriate management. Peptic ulceration may occur during severe illness or viral infections, but perforation is rare.
Duodenal Ulcer↗
High-dose intravenous immune globulin in the management of severe Guillain-Barre syndrome.
Guillain-Barre Syndrome (GBS) is the most common cause of acute generalized paralysis. Although the cause and pathogenesis of GBS remain unknown, there is increasing evidence to suggest that this syndrome has an immunological basis. Two children suffering from GBS were treated with high-dose intravenous immune globulin (IVIG) (1 g/kg/day over two consecutive days). Both children showed marked clinical improvement within 48 hours of the onset of treatment. It is suggested, on the basis of recent case reports, that immunoglobulins may have an important role in the treatment of Guillain-Barre Syndrome.
Child↗
Immune globulin treatment in intractable epilepsy of childhood.
Six children suffering from epilepsy refractory to conventional anti-convulsive therapy were treated with high-dose intravenous immune globulin (IVIG) (200 mg/kg three times per week, repeated after three weeks). In four children clinical and EEG findings markedly improved, while a partial response was noted in the other cases. These results suggest that high-dose intravenous immune globulin may have a beneficial effect in the treatment of intractable epilepsy.
Adolescent↗