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Biomedical subjects

E Barbu

Publications and source records attributed to E Barbu.

46 records · Page 3Linked to original sources

[Group tuberculous contamination in preschoolers].

The study of a new collective tuberculosis contamination is proper for us to report news about the antituberculosis fight. In 1997, an ill teacher with cavity produced 19 cases of tuberculin turnings in a class with 25 children, but none of them had tuberculosis. We tried to find an explanation. We studied another 3 epidemiological events. In 1970, a teacher from Holbav produced 80 tuberculin turnings with 42 ill children. In Săcele another teacher with cavity produced 39 tuberculin turnings with 5 ill children. In Prejmer, in 1988 a sick child with cavity made himself 28 tuberculin turnings with a single case of illness. We tried to explain these differences: similar sources (patients with cavities) and the same conditions of illness but different effects. Our epidemiological investigations showed that in Holbav only 3.6% of children had BCG vaccine; in Săcele were 18%; in Prejmer were 98%; in Codlea 96%. BCG vaccination prevents tuberculosis. But in this case is another problem, did all the tuberculin turnings signify a virulent infection? After a year when we tested again the children, we found that for 58% of tuberculin turnings the reaction diminished considerably. We consider that, this is the particularity of the evolution of the postvaccinal allergy. We conclude that hyperreactivity may be a transitory exacerbation of the postvaccinal allergy and not an evidence of the infection. BCG vaccination reduces the risk of tuberculosis even when the infection is important and virulent.

BCG Vaccine↗

[HIV infection case finding in children hospitalized in a pediatric pneumophthisiology department].

The study deals with HIV infection in children admitted to the "Phthisiopediatrics" Department of Braşov Hospital. They represent about 1% of the hospitalized cases (5 of 564). Considering, however, the age group of interest (0-5 years), they constitute 4.6% of hospitalized cases. Four of the five children were born in 1989, and all of them show a rather rich pathological history, with many hospitalizations in pediatrics departments, treatments by injections and even transfusions (2 cases). Vertical transmission being excluded--the respective mothers were negative at testing--the iatrogenic infection seems most probable. Together with the study on AgHBs carriers, where the results were similar, the present study made us think over the elementary prophylaxis measures in current medical practice.

AIDS-Related Opportunistic Infections↗

[The clinical, radiological and therapeutic aspects of endotracheobronchial foreign bodies in children].

During about 30 years of activity in the Bronchology room of the Phthisiopediatrics Unit-Braşov, 87 children having inhaled a foreign body (FB) in their airways were assisted. A number of 85 of them were solved through endoscopic interventions, performed by simple or complex (with ORL and intensive care) teams. The 85 FB were mostly (55) of vegetable nature (grains of beam and maize, seeds of pumpkin and sun flower), fragments of bone (10), of metal (10), and of plastic (8). FB localisation was: tracheal (30), in the right side bronchi (31), and left ones (26). Infancy was quite often interested: 60 children under 3 years of age and 9 aged less than 1 year. Clinical-radiological manifestation of FB were grouped in: without clearcut syndrome, well tolerated; with a clinical picture of acute pneumonia; with syndrome of complete or incomplete ("with valve") obstruction. Early diagnosis and prompt endoscopy solving prevent immediate or late complications.

Acute Disease↗

[Suppressive effect of synthetic polypeptide GT on the induction of delayed-type hypersensitivity to a complex GT + methylated bovine serum albumin (author's transl)].

Delayed-type hypersensitivity (DTH) to the random copolymers poly(Glu50Tyr50) (GT) or poly(Glu60Ala30Tyr10) (GAT) could be produced in BALB/c mice when the polymers were injected complexed to a methylated bovine serum albumin (mBSA). The pretreatment with GT or with mBSA 4 days before the immunisation with the complex GT-mBSA suppressed the induction of the DTH to both GT and mBSA moieties of the GT-mBSA complex. A similar pretreatment with GAT had no suppressor effect on the induction of DTH to GT-mBSA. Injection of cyclophosphamide 2 days before or 2 days after the pretreatment with GT eliminated the suppressor effect of GT on the induction of DTH with the complex GT-mBSA.

Animals↗

[Study of alpha 1-antitrypsin and alpha 2-macroglobulin in workers exposed to byssinogenic dusts].

The level of IgG, IgA, IgM, alpha1-antitrypsin and alpha2-macroglobulin was determined by radial immunodiffusion in 27 workmen in the flax processing industry, exposed to the risk of byssinosis and 33 retired workmen with a diagnosis of byssinosis. The control lot included 26 blood donors. A significant increase in IgM, alpha1-antitrypsin and alpha2-macroglobulin levels was noted in the active workmen; the increase was not significant in the retired workmen. The high IgM levels was brought about by the immunological processes taking place under the influence of the antigenic components of the dust inhaled; the increase in antitrypsin and alpha2-macroglobulin was considered as an acute protein reaction to the presence of inflammatory proteases.

Byssinosis↗