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Biomedical subjects

E B Mazo

Publications and source records attributed to E B Mazo.

At least 19 recordsLinked to original sources
PubMed2006

[Diagnosis of arteriogenic erectile dysfunction at the level of primary health care].

AIM: To study relations between endothelial function of the brachial and cavernous arteries (BA and CA). MATERIAL AND METHODS: The trial was made in 148 males with erectile dysfunction (ED) aged 21 to 80 years (a mean age 52.6 years) and 40 males aged 24 to 76 years (a mean age 50.2 years) with normal erection (the control group). A pathogenetic form of ED was determined in each patient. CA endothelium function was estimated in the patients and controls by an original technique of ultrasonic investigation of postcompression changes in CA diameter. Such changes were also estimated for BA diameter. RESULTS: The correlation analysis of BA and CA endothelial function has not found significant correlations between BA and CA endothelial functions both in the groups and in all the examinees. Prevalence of systemic endothelial dysfunction in the controls and patients with psychogenic, neurogenic and vein-occusive ED was maximum 30% while in arteriogenic ED endothelial dysfunction was discovered in all the examinees. CONCLUSION: In diagnosis of arteriogenic ED the study of BA endothelial function can not adequately replace such of CA, but the presence of BA endothelial dysfunction may be associated with CA endothelial dysfunction.

Adult↗
PubMed2005

[Prostanorm in the treatment of chronic non-infectious prostatitis].

AIM: To try efficacy of prostanorm against chronic non-infectious prostatitis (CNIP). MATERIAL AND METHODS: Forty two 25 to 48 year old patients with CNIP received prostanorm treatment: 2 tablets, 3 times a day 30 min before meal or 40 min after meal for 6 weeks. RESULTS: Prostanorm relieved symptoms significantly and improved quality of life, reduced prostatic size, increased maximal volumic speed of urine flow according to uroflowmetry. CONCLUSION: Prostanorm is an effective and safe drug for treatment of patients with CNIP.

Adult↗
PubMed2004

[Use of alpha-adrenoblockers in therapy of benign prostatic hyperplasia in patients with arterial hypertension].

AIM: To compare efficacy and tolerance of tonocardin (doxazosin) and omnik (tamsulosin) in the treatment of benign prostatic hyperplasia (BPH) in hypertensive patients. MATERIAL AND METHODS: Group 1 patients (n = 115, age 44-81 years) with BPH and mild or moderate arterial hypertension (AH) treated with one antihypertensive drug (ACE inhibitor--48, calcium antagonist--26, beta-blocker--22, diuretic--19) were given tonocardin in a single daily dose from 1 to 4 mg for 12 weeks. Group 2 patients (n = 30, age 67-81 years) with BPH and severe AH treated with two antihypertensive drugs and more were given omnik in a single daily dose 0.4 mg for 12 weeks. RESULTS: In group 1, tonocardin treatment resulted in lowering of a total symptoms score by IPSS scale from 17.5 +/- 3.6 to 14.7 +/- 1.3 points, of quality of life from 4.3 +/- 0.7 to 3.9 +/- 0.3, in a rise of maximal velocity of urine flow (Qmax) from 7.8 +/- 1.2 to 9.4 +/- 0.6 ml/s; residual urine (R) reduced from 112.4 +/- 8.6 to 64.5 +/- 10.2 ml). Systolic arterial pressure went down from 150.5 +/- 13 to 139.8 +/- 13.3 mm Hg, diastolic pressure fell from 86.9 +/- 6.1 to 80.8 +/- 7.1 mm Hg. In group 2, omnik resulted in IPSS scale points lowering from 17.7 +/- 3.5 to 15 +/- 1.1, QOL from 4.5 +/- 0.2 to 3.8 +/- 0.2, Qmax from 7.4 +/- 1.1 to 9.2 +/- 0.5 ml/s, R from 107.5 +/- 12.7 to 63.4 +/- 9.7 ml. Arterial pressure did not change much. CONCLUSION: Tonocardin and omnik are effective and safe not only in the treatment of BPH but also of BPH combination with AH.

Administration, Oral↗
PubMed2002

[Diagnostic and prognostic value of quantitative monitoring of prostate specific antigen in blood serum and urine from patients with prostate cancer after radical prostatectomy].

AIM: To study values of prostate-specific antigen (PSA) in the blood serum and urine before and after massage of the prostatic bed in patients with prostatic cancer (PC) after radical prostatectomy. MATERIAL AND METHODS: Changes in serum and urine PSA concentrations were followed up in 17 patients with PC (T2-3N0M0) 14 months (4-24 mon) after radical prostatectomy. Control examinations were made once a month. MRT or CT and osteoscintigraphy were made in suspected recurrence and/or metastases of PC. RESULTS: There were no changes in PSA consentrations in the serum and urine before and after the massage of prostatic bed in 10 of 17 patients. In 3 patients PSA concentrations in blood and serum increased after the massage, in one of them blood levels of PSA after the massage went up 5 months after PSA increase in the urine. In 4 of 17 patients urine PSA levels increased after the massage, the blood levels remaining the same. CONCLUSION: Follow-up measurements of blood and urinary levels in PC patients after radical prostatectomy before and following massage of the prostatic bed allow detection of prostatic PSA-positive cells which were not removed at surgery. We suggest that these cells may be the basis of recurrent disease.

Humans↗
PubMed2002

[Features of BCG-therapy in treating patients with superficial bladder cancer].

AIM: To specify features of BCG-therapy which may predict effectiveness of the treatment and optimize the treatment regimen. MATERIAL AND METHODS: Intravesical immunotherapy with imuron (a 6-week course) was conducted in 62 patients with superficial cancer of the urinary bladder who had undergone surgical treatment and were prognostically poor. 51 patients of group 1 received maintenance therapy as 3 weekly instillations each 3 months for the first year followed by once in 6 months. 11 patients of group 2 received single monthly instillations. All the patients registered their complaints, measured body temperature with fixation of maximal value. The diagnosis of the recurrence was made with control cystoscopy carried out each 3 months in the first postoperative year and later once in 6 months. RESULTS: Recurrent tumors were observed in 25 (49%) and 7 (63.6%) patients of groups 1 and 2, respectively. Side effects (high body temperature, dysuria and macrohematuria) were reported in group 1 during basic treatment. Side effects occurred also in maintenance. They were more pronounced than in group 2. CONCLUSION: Intravesical BCG-therapy causes cystitis considered a normal reaction to treatment. Fever indicates an inflammatory reaction which is rather a positive sign of immune reaction and may serve a prognostic factor.

BCG Vaccine↗
PubMed2002

[A new approach to raising the efficiency of drug therapy for erectile dysfunction].

AIM: To try combined treatment of erectile dysfunction with viagra and alprostadil in case of failure of their monotherapy; to compare effectiveness of viagra in dynamics of treatment, in various doses and dose adjustment. MATERIAL AND METHODS: 82 patients with ED of different genesis received a course of intracavernous injections of alprostadil followed by a course of viagra; 25 patients received combined treatment with alprostadil and viagra. Each course lasted for 3 months. Viagra efficiency was also assessed in long-term use (12 months) and different initial doses (50 or 100 mg). RESULTS: Monotherapy with alprostadil or viagra was effective in 73.2 and 75.6% patients, respectively. Their combination was more beneficial--88.0%. When used for a long time, viagra lost efficiency in psychogenic ED by 17.7%, in organic ED--by 16.9%. In an initial viagra dose 50 mg efficiency reached 70.3%, 100 mg--80.0%. CONCLUSION: Combined treatment of ED is a method of choice in monotherapy failure and in severe ED. Lowering of viagra efficiency in long-term administration may be explained by disappearance of placebo effect.

Adult↗
PubMed1997

[The treatment of patients with benign prostatic hyperplasia using the selective alpha-blocker alfuzosin].

40 patients with benign prostatic hyperplasia (BPH) were treated with the alpha-blocker alfuzosin which was administered per os twice a day in a dose 5 mg. The treatment brought about a decrease of the mean symptom score from 19.6 to 12.2, of quality of life from 5.2 to 2.1, of residual urine from 152 to 82 ml. Mean and maximal urinary flow rates rose by 35 and 45%, respectively. The level of prostate-specific antigen over the treatment course did not change. The findings of the trial evidence for high efficacy of alfuzosin in the treatment of urination disorders in BPH patients.

Adrenergic alpha-Antagonists↗
PubMed1996

[The use of serpens for treating patients with benign prostatic hyperplasia].

320 mg of serpense was given daily to 24 patients with benign prostatic hyperplasia (BPH) for 2 months. Control check-ups were performed each 30 days. The effect was judged by the patient's condition (I-PSS), quality of life, residual urine, the gland size, urodynamic picture and level of prostatic specific antigen (PSA). The response of BPH to serpense was noticeable, especially at the first stage of the disease (66.7%). Reduced serum PSA in serpense-treated patients may be explained by peripheral selective inhibition of 5 alpha-reductase or, rather, by anti-inflammatory action of the drug. Antidropsical and antiinflammatory actions of serpense suggest its possible efficacy in chronic prostatitis.

Aged↗
PubMed1994

[Left-side varicocele and infertility: diagnosis and treatment].

Eighty-four patients with left varicocele were subjected to complex examination to identify the causes of disturbed spermatogenesis. It was found that not only the testis but the adrenal also is involved in the pathological process in varicocele caused by venous renal hypertension. Changes of venous hemodynamics in the left adrenal lead to activation of steroidogenesis in its cortex and, consequently, to impairment of spermatogenesis in both testes. As the result of the study a new method for the treatment of sterility in patients with left varicocele was suggested, namely, X-ray-guided endovascular occlusion of the central vein of the left adrenal. Tentative evaluation of the results of the intervention gives hope of its efficacy.

Adolescent↗
PubMed1990

[Diagnosis and roentgeno-endovascular treatment of patients with renin-dependent arterial hypertension and secondary aldosteronism without damage to the main renal arteries].

Bilateral electrocoagulation of the central veins of the adrenals (ECVA) was performed in 13 patients with stable and malignant arterial hypertension (AH). The renin-dependent character of AH was supported by positive reaction of arterial pressure (AP) to the test dose of captopril (25 mg). The vasorenal origin of the impairment was excluded on the basis of the peripheral captopril test findings, pharmacorenography with captopril. Bilateral ECVA was done during angiography. The manipulation turned out technically successful in 11 left (85%) and 9 right (70%) adrenals. The AP began lowering from the first days of the intervention and got stabilized by day 4 to 5. There was a significant decline of AP within the observation period up to 1 year and a reduction of the elevated aldosterone content and plasma renin activity with the content of ACTH being unchanged. After the manipulation 2 patients could fully discontinue the intake of hypotensive drugs. In 11 patients, the dose of the drugs could be reduced.

Adrenal Glands↗
PubMed1989

The role of impairment of adrenal mineraloglucocorticoid function in the development of infertility in varicocele patients.

The study was aimed at the understanding of pathophysiological mechanisms of the impairment of spermatogenesis in varicocele patients. The crucial role of tension increase in the venous plexus of the spermatic cord in spermatogenesis damage in the testis on the varicocele side and absence of any effect of haemodynamic abnormalities on spermatogenesis in the complementary testis has been determined. Retrograde blood flow through the central vein of the left adrenal gland in varicocele has been evidenced by X-ray examination. The role of this phenomenon in the changes of functional activity of the adrenal gland is discussed. Results of the study of functional status of adrenal glands revealed their tendency to provide hyperactivity in synthesis of mineraloglucocorticoids. Correlation between cortisol level in peripheral blood and percentage of abnormal sperm in ejaculate was shown. This fact supported the idea about the existence of a causal interrelationship between abnormalities in the functional status of adrenal glands and development of infertility in varicocele patients.

Adolescent↗