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Biomedical subjects

E Astorri

Publications and source records attributed to E Astorri.

At least 55 records · Page 3Linked to original sources
PubMed1986

Left ventricular diastolic filling rate assessed by gated radionuclide angiography in patients with coronary artery disease.

This study was undertaken to determine the significance of diastolic left ventricular function in 26 normal subjects and in 74 patients with coronary artery disease (CAD). Gated radionuclide left ventriculography in supine position and left anterior oblique projection was performed at rest in both groups considered and during exercise in 11 normal subjects and in 35 patients with CAD. Compared with the normal subjects, the group of patients with CAD showed lower values of global and regional ejection fraction as well as of peak ejection and filling rates. 33 patients with CAD, presenting an ejection fraction greater than 54%, showed similar values of global and regional ejection fraction, compared with the group of normal subjects, while peak filling rate was significantly lower. During exercise peak filling rate significantly increased in normal subjects and in patients with CAD; this increase was constant and similar in the various subgroups considered among patients with CAD. We conclude that peak filling rate represents a more sensitive index than ejection fraction in evaluating left ventricular function in patients with CAD, as shown by the comparison between normal subjects and patients with CAD, who had an ejection fraction greater than 54%.

Adult↗
PubMed1980

[Computer analysis of the vectorcardiogram].

A computer method analysing Frank VCG recorded on rest and on exertion, is presented. Electrical noises due to exercise are eliminated by averaging 8 complexes. The pattern-recognition of every wave is carried out by analysing a particular function obtained by translating the X, Y, Z leads on the line joining the T-P, P-Q, ST and subsequent T-P segment. The following parameters are evaluated: maximal and mean vector, linear, areolar and tangential (our original method) spatial velocity, half-area vector, area described by the spatial vector and oriented according to X, Y, Z polarity.

Diagnosis, Computer-Assisted↗
PubMed1980

[The atrial vectorcardiogram at rest and during exercise. Comparison, by computerized analysis, of normal subjects and patients with mitral stenosis].

This study on rest and exercise atrial vectorcardiogram (Frank method) was carried out on a group of 27 healthy volunteers (Group A) and on a group of 24 patients with mitral stenosis (Group B). All 51 subjects were women. Our original program was performed using a Hewlett Packard 2100 computer. The pattern recognition of every wave was carried out by analysing a particular function obtained by translating the X, Y, Z leads on the line joining the T-P, P-Q, ST segments. In the group B on rest a significant correlation between atrial vectorcardiogram parameters and pulmonary capillary wedge pressure was not present. Between both group A and B the vectorcardiographic data were greatly superposables. It is difficult, because of the great interindividual variability of results obtained, to have very discriminant vectorcardiographic parameters between group A and group B on rest and during exercise, performed in the supine position with a bicycle ergometer. In the both groups A and B the exercise induces a significant increase of spatial magnitude of maximal P xyz vector (max P xyz) and maximal P amplitude on frontal and sagittal planes, with P loop shifting towards a vertical position. The following significant results were observed only in group B of mitral patients: 1) an increase of P wave duration; 2) an increase of the interval between the two peaks of P wave (measurable only in group B); 3) an increase in the amplitude and backward rotation of max P xyz azimuth and of the maximal vector backward directed on horizontal (H) plane; 4) an increase of P loop linear, tangential and areolar velocities. The P loop anterior and posterior area on H plane and of the spatial P xyz vectors changes during exercise were directionally similar in the normal group and in the patients with mitral stenosis. These results suggest a little diagnostic power of the P wave area changes during exercise. In both groups maximal atrial T vector increases with exertion, but only in group B migrates backward on H plane, suggesting an atrial gradient directed towards the left atrium.

Adult↗
PubMed1979

Bioavailability and related heart function index of digoxin capsules and tablets in cardiac patients.

A loading dose of digoxin (750 microgram) in two commercial formulations was administered to 14 patients with heart disease according to a crossover design. One formulation consisted of soft gelatin capsules containing a solution of digoxin; the other formulation was compressed tablets. All parameters investigated, i.e., serum peak height, time of the peak, area under the serum level--time curve (AUC), and area above the Q--S2I (electromechanical systole) decrease (obtained from polycardiographic evaluation), showed better bioavailability of digoxin capsules than tablets, averaging 36.3%. The better bioavailability of digoxin capsules than tablets seems to be more evident in heart disease patients than that encountered previously in healthy subjects. The AUC and the area above the Q-S2I decrease were linearly correlated only with digoxin capsules.

Adult↗