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Biomedical subjects

E Aron

Publications and source records attributed to E Aron.

70 records · Page 4Linked to original sources
PubMedDate not supplied

[Electrophysiologic abnormalities in chronic alcoholism, disclosed by the methods of evoked potentials and Hoffman's reflex. Study of a possible metabolic pathogenesis].

During a preliminary study comparing 5 normal subjects and 5 alcoholics (25 experiments) changes in evoked potentials were found in these patients. There was mainly a reduction in these potentials during the first 100 milleseconds following stimulation. Such a reduction generally means a disorder of the arrival of the influx at the level of the cortex and may be found mainly in peripheral nerve involvement. A complementary study of the H reflex (34 experiments) showed that this reflex was affected in 60% of chronic alcoholics whether or not they had liver cirrhosis. The theory according to which the EEG abnormalities observed may be linked to a metabolic disorder of the amino-acids was not confirmed. The changes of the first 100 milleseconds of the evoked potential associated with the change in Hoffman's reflex are in favour of early peripheral involvement even in alcoholics who do not appear to have any peripheral neuritis. These signs are different from those which are observed in marijuana or psylocybine poisoning where the EEG signs are due to central involvement.

Alcoholism↗
PubMedDate not supplied

[Detection of excessive chronic alcoholic consumption and control of withdrawal. Comparative study of respective values of the mean red-cell volume and serum gamma-glutamyl-transferase activity].

The routine detection of chronic alcoholism is necessary during any medical examination whether private or in hospital, or in occupational medicine. The practitionner now has available a simple reliable and cheap test. It consists of the serum estimation of gamma-glutamyl-transferase (gammaGT) and interpretation of the average red cell volume supplied by automatic counting of the red cell. Out of 120 chronic alcoholic subjects ; 67% has a gammaGT increased and 44% had macrocytosis. Under the influence of weaning, there was a rapid fall in gammaGT and a slower reduction in average red cell volume. gammaGT estimation was thus a more sensitive test than M.C.V. for the detection of chronic alcoholics and the control of withdrawal. Its association with the rise in immunoglobulin A-transferrin ratio which we have suggested permits the detection of almost all chronic alcoholics in the population studied.

Acyltransferases↗