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Biomedical subjects

E Anton

Publications and source records attributed to E Anton.

52 records · Page 3Linked to original sources
PubMed1965

Nuclear mitochondria?

Recognizable mitochondria were detected in the nucleus of a leukemic cell. It is suggested that passage through enlarged nuclear pores, incorporation within a pinched off invagination, or inclusion within the nuclear envelope at telophase may have been responsible for this unusual event.

Animals↗
PubMedDate not supplied

Differential sensitivity of DBA/2 and C57BL/6 mice to cyclophosphamide.

Early and delayed toxicity of a single dose of 300 mg kg-1 cyclophosphamide (CP) was investigated in male DBA/2 and C57BL/6 mice. Early toxicity (up to 30 days after CP administration) resulted in 36.6% lethality in DBA/2 and no mortality in C57BL/6 mice. Delayed toxicity (after 30 days) occurred primarily in DBA/2 mice, resulting in a survival of 3% in DBA/2 and 93% in C57BL/6 mice on day 125 after CP administration. Early modifications brought about by CP in erythrocytes and leucocytes, and spleen and liver indexes (mg organ g-1 body wt.) were rather similar in DBA/2 and C57BL/6 strains. However, CP treatment caused a profound cell depletion in DBA/2 bone marrow owing, in part, to the fact that the number of cells in bone marrow of normal DBA/2 mice was much lower than that in normal C57BL/6 mice. Furthermore, the thymus index (mg organ g-1 body wt.) decreased sooner in DBA/2 than in C57BL/6 animals and no sign of recovery was evident in the former even after 10 days, whereas recovery in the latter started on day 5 after injection. Differential sensitivity of DBA/2 and C57BL/6 strains to CP could be due to differences in activation and/or inactivation of the drug, or to the increased effect of CP on DBA/2 bone marrow resulting in damage to pre-T cells that normally participate in thymus recovery.

Animals↗
PubMedDate not supplied

[CA 15-3 and CEA markers - prognostic factors in breast cancer].

For the increasing of sensibility and specificity in the monitoring of the diagnosis and treatment of breast cancer it is used the simultaneous determination of two tumoral markers: CA 15-3 and CEA. This study try to demonstrate the grade of involvement in diagnostic and screening. We have determinate CA 15-3 and CEA in 73 serum samples. The correlation between the stage of malignancies and CA 15-3 levels was relieved in the second section of this study. The third section follow up the dynamic evolution of CA 15-3 marker in pre- and postoperator (14 days) stages obtaining a decreasing of CA 15-3 level. The obtained results for CEA does not establish any clinical rules in order to compare with the CA 15-3 level and disease stages. The easy-used and non-invasive determination, the early increasing of it's level and it's preservation recommend glycoprotein CA 15-3 like an current clinical instrument.

Breast Neoplasms↗
PubMedDate not supplied

[Gastroesophageal reflux disease in pregnancy].

Gastroesophageal reflux disease (GERD) symptoms are common in pregnancy, occurring in approximately 45% to 80% of pregnant women. Although the symptoms associated with reflux in pregnancy are similar to those described in the nonpregnant state, some of the etiologies are distinct due to hormonal fluctuations and other physiologic changes often associated with pregnancy. Diagnostic tools and therapeutic regimens that might be used without hesitation in the nonpregnant patient must be given with cautious consideration in the gravid patient due to potential fetal risks. Pregnant patients with symptomatic GERD should be managed aggressively with lifestyle modification and dietary changes. Antacids and antacids/alginic acids combination or sucralfate should be considered first-line medical therapy; treatment with cimetidine or ranitidine should be considered; these H2 receptor antagonists are preferred during pregnancy. Proton-pump inhibitors should be used with caution because little human experience is available.

Anti-Ulcer Agents↗
PubMedDate not supplied

[Gastroesophageal reflux during pregnancy: 24-hour esophageal ph monitoring].

Gastroesophageal reflux (GER) occurs in 30-50% of all pregnancies. The progressive rise in plasma progesterone has been suggested as a possible mediator of GER during pregnancy. Recent advances in technology have made it possible to detect GER through monitoring of esophageal pH for prolonged periods, including sleep. 24-hour pH monitoring is the proper method for diagnosing GER in pregnant women. If 24-hour esophageal pH monitoring is to be a useful diagnostic tool, it must reliably discriminate GER patients despite daily variations in distal esophageal acid exposure. To address this issue, we studied 62 women (30 healthy non-pregnant women without GER symptoms and 32 pregnant women with GER symptoms-heartburn, acid regurgitation) with 24-hour esophageal pH monitoring. Intrasubject reproducibility of three pH parameters to discriminate the presence of abnormal acid reflux was determined (DeMeester score, Kaye score, circadian one hour diagram for pH < 4). Each patient was interviewed, using a reliable questionnaire detailing individual habits, life style characteristics and symptoms, at four time points during the first, second, third trimesters of pregnancy and post-partum period. Symptoms of GER are common in pregnancy and although GER rarely endangers maternal or fetal health, it can significantly affect patient comfort and quality of life. We conclude: 1. GER is almost constantly present during pregnancy, increasing with gestational age. 2. The most important pH--parameter is DeMcester score. 3. Heartburn disappear after delivery. 4. 24-hour esophageal pH monitoring is the gold standard for measuring acid exposure and is a reproducible test for the diagnosis of GER in pregnancy.

Adult↗
PubMedDate not supplied

[Hormonal influence on gastrointestinal reflux during pregnancy].

UNLABELLED: Gastroesophageal reflux (GER) occurs in 30-50% of all pregnancies. The progressive rise in plasma progesterone has been suggested as a possible mediator of GER during pregnancy. It is not known whether progesterone, at physiological concentrations, has an effect on acid contact time. The study includes 70 women--50 pregnant and 20 non pregnant healthy menstruating female volunteers. We used immunoenzymatic tests for determination of estradiol, progesterone and beta HCG hormones during pregnancy. The 50 pregnant women with GER symptoms heartburn, acid regurgitations had increased levels of steroid hormones. 24-h ambulatory esophageal pH monitoring and serum progesterone levels were determined in 20 healthy women known to have normal menstrual cycles. All tests were performed during the follicular phase days 2-7 and the luteal phase days 22-28 of one or two consecutive menstrual cycles. The fluctuations in progesterone levels across the normal menstrual cycle have no significant impact on 24-h ambulatory pH parameters. CONCLUSIONS: Progesterone, at physiological concentrations, does not predispose to GER in healthy menstruating women. Thus, it is likely that if progesterone, with or without estrogen, contributes to GER in pregnancy, this effect takes place only at the high concentrations observed during this condition. After delivery, GER disappear with decreasing hormonal levels and uterine volume.

Adolescent↗
PubMedDate not supplied

[Cervugid ovules in cervico-vaginal infections and cervix uteri precancerous conditions treatment].

UNLABELLED: This medicine was authorized by the National Drug Agency (ANM, Bucureşti) in 2001. PURPOSE: To evaluate the effectiveness and the tolerance to Cervugid-ovules, a preparation that combines the polyvalent local antiinflammatory action of chloramphenicol, metronidazole and nystatin with the effect of hydrocortisone acetate, an unspecific anti-inflammatory agent; they all are embedded in a Lipex-403, semisynthetic fat. MATERIALS AND METHODS: The evaluation of 500 patients ages between 15 and 85 years with genital infections, registered in the files of "Cl. II Obst. and Gynecology" of the Cuza-Vodă Hospital from Iaşi has been studied. We studied the subjective manifestations (local discomfort and pelvic pains, local burning and dryness,vulvovaginal itching and dyspareunia) and objective manifestations (vaginal and cervical secretion, the cytotest performed and colored though the Papanicolaou method and reported in the Bethesda system). RESULTS AND DISCUSSION: Healing of the subjective symptoms in 98%, healing of the leukorrhea--as a main objective symptom--in 95%; The Bethesda system cytotest was one of the inflammatory type in the most of the cases and there wew found in 85 cases: 6 ASCUS, 41 LSIL, and 37 HSIL. The use of Cervugid had a healing response in most of the cases when used in acute and chronic cervico-vaginal inflammatory processes. Cervugid may be considered as an important agent in the treatment of the precancerous affections af the cervix uteri on the following reasons: zhe cure of the infections caused by chlamydia, involved in the etiology of cervical neoplasms, the cure of the HPV infection under episome form, classified in the Bethesda system within the ASCUS, AGUS or LSIL classes. When the cytotest was in the HSIL class, a conization in the LLETZ method was performed. CONCLUSIONS: Cervugid is conceived for those three main categories of pathogenic factors related to the etiology of cervico-vaginitis: microbia germs, protozoa and mycosis. In addition, it is active on chlamydia and mycoplasms, always sensitive to chloramphenicol therapy. That is why Cervugid with in local administration is indicated in the microbial, trichomoniasis and mycotic vaginitis caused by one category of pathogenic agents or by associated forms, in cervicitis, in the pelvic inflammatory processes (pelvic congestion, metritis, adnexitis, and inflammatory processes associated with benign or malignant tumors of the genital apparatus). The results obtained proved that Cervugid is highly effective medicine.

Administration, Intravaginal↗
PubMedDate not supplied

[Significance of hysteroscopy in the diagnosis and treatment of infertility].

Hysteroscopy is an excellent additional instrument for evaluating the uterine characteristics in infertile women. Retrospective study analyses the importance of hysteroscopy in diagnostic and treatment of infertility. Patients were selected from 1st Clinic of Obstetrics and Gynecology Iaşi during 1997 and 2004. Study group included 602 hysteroscopy performed in our clinic with 480 cases of infertility. 28.9% were primary infertility and 49.1% were secondary infertility, rest of percentage been intrauterine synechia, septum, polyps and foreign bodies. Polyp ablation located near the tubal ostia (50 cases), synechia repair (90 cases), were the most common operative procedures. Good results in removal of foreign bodies (16 cases) were obtained pregnancy rate more than 75%. Operative hysteroscopy is similar to diagnostic hysteroscopy except that a ideal hysteroscope is used to allow operating instruments such as scissors, biopsy forceps, electrosurgical or laser instruments, and graspers to be placed into the uterine cavity through a channel in the operative hysteroscope. Fibroids, synechia, and polyps can be removed from inside the uterus. Congenital abnormalities, such as uterine septum, may also be corrected through the hysteroscope.

Female↗
PubMedDate not supplied

[The prevention of urinary tract injuries in obstetrics].

The aim of this study was to warn young obstetricians of the traumatic injuries to the urinary tract in their daily practice. After a short description of the changes that occur in pregnancy and puerperium at the urinary tract, we present "details" of some methods in order to avoid the urethral, bladder and ureteral injuries during vaginal delivery and some obstetric procedures (caesarean section, hysterectomy). This article represents a small and useful guide for young obstetricians in order to avoid unpleasant situations that can occur in their obstetric practice.

Cesarean Section↗
PubMedDate not supplied

[Peritoneal suture vs. non-suture at caesarean section].

UNLABELLED: To assess intraoperative, early and late postoperative morbidity followings non-closure of parietal and visceral peritoneum during caesarean section as compared to usual peritonization. Two groups of 40 pregnant women each were randomized to either closure (n = 40) or non closure (n = 40). Statistical analysis compared intraoperative and postoperative outcome between the two groups. RESULTS: There was significant reduction in operating and anesthesia time, febrile morbidity, return of bowel function and period of hospitalization among the non closure group. Peritoneal adhesions and upward displacement of bladder were more frequently noted during a subsequent caesarean in the closure group. Non closure of the peritoneum during caesarean section is a shorter, simpler, cost effective procedure associated with lesser febrile morbidity and hospitalization, early return of bowel function, reduced frequency of the postoperative adhesions and upward displacement of bladder.

Adult↗