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Biomedical subjects

E Andersson

Publications and source records attributed to E Andersson.

At least 127 records · Page 7Linked to original sources
PubMed1987

A follow-up study of leg and foot ulcer patients.

Three hundred and fifty patients treated in 1980 at the Department of Dermatology for leg and foot ulcers were asked to come for an interview concerning the development of their ulcerations up to the end of 1983. Forty-five of 186 patients were free from ulcers from 1981 to 1983. Thirty patients had leg ulcers continuously throughout the period and their ulcers were not healed at any time. Ninety-six patients had died during the follow-up period, and the total mortality rate compared to an age-matched population was shown to be approximately doubled for both men and women. When analysing the causes of death, it was found that the ischemic heart disease mortality rate was twice that of the age-matched population but the mortality rate for malignant diseases was about the same.

Adult↗
PubMed1984

Leg and foot ulcers. An epidemiological survey.

Medical records for leg and foot ulcer patients have been investigated, 1377 patients were found. The median age for women was 76 years and for men 70 years. Totally there was a majority of women, 61%. The age specific frequencies for leg and foot ulcer patients did however not differ between men and women. Thirty percent of all patients had ulcers on the feet only. The ratio between men and women for feet ulcers was 1:1. Men got their feet ulcers 5-10 years earlier than women. Seventeen percent of all patients had ulcers on the medial side of the calf only. Seventy percent of these patients were women. A rough estimate of the prevalence of leg and foot ulcer patients was made to between 0.2-0.4% of the whole population. The involvement of different medical disciplines in the care of leg and foot ulcer patients in Gothenburg is reported.

Adult↗
PubMed1983

Muscular high-energy phosphates and red-cell 2,3-DPG in post-traumatic hypophosphataemia. An experimental study in pigs.

The relationship between post-traumatic hypophosphataemia, muscular high-energy phosphates (HEP) and red-cell 2,3-diphosphoglycerate (2,3-DPG) were studied in an experimental trauma model. Twenty-three anaesthetized pigs were submitted to trauma and observed for 72 hours. In group I (n = 10) and group II (n = 6) major trauma was inflicted with a high-energy missile. No phosphate supplement was given in group I, but group II pigs received 20 mmol phosphate/24 hours parenterally. Group III (n = 7) sustained only minor trauma, consisting of tracheotomy and catheterization of artery, vein and bladder, and received no phosphate in the post-trauma observation period. Reduction of serum phosphate was found in all groups after trauma. In skeletal muscle, decreased levels of HEP were observed after major trauma, whether or not phosphate supplement was given. Following minor trauma there was no alteration of muscle HEP. In red-cells, 2,3-DPG decreased slightly only after major trauma in pigs without phosphate supplement. Conclusions from the study were that hypophosphataemia was associated with cellular metabolic disturbance only after major trauma. In red-cells this disturbance seemed to be prevented by administration of phosphate. In skeletal muscle the phosphate supplement could not prevent fall in HEP levels, possibly because of a post-traumatic insulin resistance in muscle tissue, which may prevent uptake of phosphate into muscle cells.

Animals↗
PubMed1980

Long-term treatment of hypertension with labetalol.

The effect of long-term treatment with labetalol was evaluated in an open clinical investigation in a total of 32 patients (15 women, 17 men), mean age 56 years (range 18-81 years). Labetalol was used in a mean daily dose of 1356 mg (range 400-3000 mg) either as mono-therapy or in combination with other drugs. Twenty-three patients were treated for more than six months, with a mean period of treatment of forty months. Thirteen of these 23 patients continue on treatment with a mean period of treatment of fifty-one months (range 6-65 months). This study does not lend support to the idea of tolerance developing to the effects of labetalol. There were no signs of liver, kidney or bone marrow involvement, and there were no changes in the retina. In 13 of the 32 patients the treatment was discontinued following subjective complaints possibly induced by the drug, partly orthostatic hypotension, and partly side effects probably related to the beta- adrenoceptor blocking effect of labetalol. Until the incidence of subjective side effects has been carefully evaluated labetalol will be used with reservations, especially as a first choice in the treatment of hypertension.

Adolescent↗
PubMed1978

Intellectual functioning in a 70-year-old urban population.

A subsample of 229 persons from the population study "70-year-olds in Gothenburg" was studied with different intelligence tests. The non-response was 15%, and another 4% refused to take part in the psychological examination or had handicaps which made the performance of all or some of the tests impossible. Measurements were made of verbal meaning (SRB1), reasoning (SRB2), spatial ability (SRB3), perceptual speed (Ps-if) and logical thinking and observation (Raven's Coloured Progressive Matrices). There were no differences in the tests between men and women except with Raven's Coloured Progressive Matrices, where the men had a better score. Amongst the women, those who had received a longer education had a better score compared with those who had had less education. Norm-tables for the different tests are presented. As far as could be judged from cross-sectional comparisons the average general cognitive capability was good, even though the 70-year-olds to a higher degree were suffering from mental disorders than younger individuals and more often were living in social situations that could have influenced basic physical and mental functions. The perceptual speed was the only ability that showed a marked change at the age of 70.

Age Factors↗
PubMed1976

Acute effect of intravenous labetalol in the treatment of systemic arterial hypertension.

1 The acute anti-hypertensive effect of intravenously administered labetalol, a combined alpha- and beta-adrenoreceptor antagonist, has been assessed in a pilot study involving 17 hypertensive patients. 2 In 11 patients with mild to moderately severe hypertension, there was a decrease in mean arterial pressure (24 mmHg) after a single intravenous dose of 50 mg labetalol. The peak response occurred approximately 4 min after administration of the drug. 3 In six patients with severe hypertension, there was a reduction in mean arterial pressure of 19 mmHg, but this was achieved after a further 50-mg dose administered 30 min after the initial injection. 4 In neither group was there any clinically significant decrease in heart rate, and drug-related side-effects were insignificant. 5 Labetalol reduced the blood pressure when administered intravenously and thus merits further investigation as a treatment for acute hypertensive crises.

Acute Disease↗