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Biomedical subjects

E Andersen

Publications and source records attributed to E Andersen.

At least 163 records · Page 9Linked to original sources
PubMed1981

Macular function in typical and reticular retinoschisis.

Fifty-three patients with typical and reticular degenerative retinoschisis were evaluated. They demonstrated a corrected visual acuity of 20/20 except when some independent and unrelated ophthalmic condition was present. With a special protocol of test procedures, macular function in nine degenerative retinoschisis patients was found not significantly different from macular function in nine control patients. Macular function prognosis associated with degenerative retinoschisis is favorable, and implications for differential diagnosis are presented.

Aged↗
PubMed1981

Modification of the platelet suspension immunofluorescence test.

This study reports two modifications of the Platelet Suspension Immunofluorescence Test which make it more convenient to use for the rapid identification of platelet-specific antibodies and for screening individuals if platelet donors of a particular type are urgently required. Platelets frozen both before and after paraformaldehyde (PFA) fixation were compared with fresh PFA-fixed platelets using anti-PLA1 and anti-HLA antisera. Further, a comparison was made between the results of the test when performed in tissue culture trays or in tubes as originally described. Platelets, prefixed with PFA and then frozen appeared similar in all respects to fresh PFA-fixed platelets with no loss of antigenicity and no non-specific fluorescence. Although platelets fixed after frozen storage were also satisfactory, they were less convenient to use and lost some brilliance in staining. When the test was performed in tissue culture trays, there was no loss in sensitivity, and the volume of antiserum used was halved. However, the main advantage was the efficiency and ease with which the test could be performed, especially when handling large numbers of samples.

Antibodies↗
PubMed1981

Risk factors in multiple sclerosis: tuberculin reactivity, age at measles infection, tonsillectomy and appendectomy.

The purpose of the present study was to investigate whether risk of multiple sclerosis (MS) is associated with the occurrence of viral or bacterial diseases, with vaccinations, or with operative events during childhood. Our reference population was 198,000 persons recorded in the register of school health records from the Copenhagen council. We compared 92 MS patients contained in the register with matched controls from the register, three for each patients. Risk of MS was inversely associated with a positive tuberculin skin test at age 7 years, i.e. with exposure to tuberculosis before the age of 7, possibly also with the occurrence of measles infection before age 7 (not statistically significant). Disease risk was not significantly related to other viral or bacterial infections of childhood, nor to routine vaccinations, tonsillectomy, adenoidectomy or appendectomy. Our findings suggest a difference between MS patients and controls with respect to environment before school age, the former being less exposed to air-borne infections.

Adenoidectomy↗
PubMed1980

Risk of multiple sclerosis inversely associated with birth order position.

The aim of this study was to ascertain whether there is an association between risk of multiple sclerosis (MS) and birth order position. Our reference population was 198,000 persons born in the period 1930-50 and recorded in the register of school health records from the school health service of the Copenhagen council. We compared 46 persons from the register who had developed MS with matched controls from the register, three for each case. An inverse association between risk of MS and birth order position was found. Early birth orders tend to delay exposure to an infectous agent from early childhood to a later age. Therefore, our finding supports the hypothesis that MS is causally related to an infection that is inapparent when it occurs in early childhood, while infection later in life may result in severe disease

Birth Order↗
PubMed1980

A case of cold haemoglobinuria with later sarcoidosis. Treatment with plasmapheresis and immunosuppressiva.

A case of severe but transient haemolytic disease occurring after a febrile episode is described. The thermal amplitude of the haemolysin was high during the acute phase, since the autoantibody fixed complement at 31 degrees C. After 4 months complement fixation could exclusively be demonstrated at 4 degrees C. The patient was treated in a room heated to 30-32 degrees C. The treatment consisted of prednisone and azathioprine and during the acute phase plasmapheresis was attempted in order to reduce the antibody concentration. However, the haemolysis decreased when the thermal amplitude of the antibody diminished. 1 year after termination of therapy, she developed sarcoidosis.

Adult↗
PubMed1980

Acute myeloblastic leukaemia in sarcoidosis treated with methotrexate.

A 60-year-old man with sarcoidosis of skin and knee joints was treated with prednisone and methotrexate (MTX). A total of 590 mg MTX was given over two periods each of 3 months duration. 4 1/2 years after the first MTX dose he developed acute myeloid leukaemia. Only one more case of acture myeloid leukaemia following MTX treatment for a benign disease has been described, and until further cases have been reported the correlation might be considered a matter of simple coincidence.

Blood Cell Count↗
PubMed1980

Procarbazine-induced skin reactions in Hodgkin's disease and other malignant lymphomas.

A total of 44 patients with Hodgkin's disease and 23 patients with non-Hodgkin malignant lymphoma were treated with MOPP-combination chemotherapy. 4 patients with Hodgkin's disease and 8 with non-Hodgkin lymphoma developed urticaria or maculo-papular rash. This frequency of hypersensitivity reactions is higher than that expected from the few cases reported in the literature.

Drug Hypersensitivity↗
PubMed1980

Radiotherapy versus radiotherapy plus chemotherapy in stages I and II Hodgkin's disease. A prospective, randomized study by the Danish National Hodgkin Study Group, LYGRA.

In a multi-centre study in which data from all Danish Hodgkin patients have been registered since 1971, all patients in supradiaphragmatic stages I or II, as confirmed by staging laparotomy, were randomized to either radiotherapy (RT) to supra- and infradiaphragmatic lymph node regions (total nodal irradiation, TNI), or RT to a mantle field followed by 6 cycles of MOPP combination chemotherapy (RT+CT). Interim results up to July 1979, when 237 patients had entered the study, showed a treatment failure rate of 19/117 in the TNI group and 4/120 in the RT+CT group (P less than 0.05). 19 of the 23 relapsing patients were under the age of 40, and 14 in the TNI group and 3 in the RT+CT group belonged to stage II. 13 patients had nodular sclerosis, 9 had mixed cellularity and 1 had lymphocytic predominance histology. 12 of 19 relapsing patients in the TNI group had hilar or mediastinal involvement as against 51 of the 117 patients in the entire group. Most of the TNI failures could be retreated, and as yet there is no difference in the overall survival.

Adolescent↗
PubMed1980

Age-dependent variations in serum 1,25-dihydroxyvitamin D in childhood.

Circulating 1,25-dihydroxyvitamin D (1,25-(OH)2D) was measured in 87 children aged 3 months to 15 years, and in 11 adolescents 16-19 years of age. A positive correlation to growth velocity was observed, indicating that the biologically active vitamin D metabolite is an important physiological factor in the regulation of growth and development of the skeleton.

Adolescent↗
PubMed1978

Lymphocytotoxic antibodies and bone marrow grafts from HLA-identical siblings. I. HLA antibodies.

In a series of 30 bone marrow grafts (in 29 recipients) from HLA-identical siblings for aplastic anemia, no correlation was demonstrated between rejection and pregraft HLA antibodies (P greater than 0.50). However, after grafting, HLA antibodies persisted in nine cases and graft rejection occurred, whereas in all but one of the remaining eight cases the HLA antibodies disappeared and a permanent engraftment was observed (P = 0.0008). These results suggest a relationship between engraftment and persistence or disappearance of HLA antibodies as an indication of the level of immunosuppression obtained with the conditioning regimen.

Antibody Formation↗
PubMed1978

Pre-morbid factors in Hodgkin's disease. I. Birth weight and growth pattern from 8 to 14 years of age.

The risk of Hodgkin's disease (HD) in young adults is correlated to height. This association indicates an etiologic factor acting during growth. Our aim was to evaluate the importance of growth pattern as a risk factor in HD. The register of records from the school health service of the Copenhagen Council was scrutinized in order to find Danes with HD born between 1930 and 1950. Whenever possible, three matched controls (comparable in respect to socio-economic status) were selected from the register for each case. The material consisted of 63 cases and 183 controls. Information regarding height, weight and birth weight was obtained from the school health records. The patients were taller than controls at 8, 10, 12 and 14 years of age. The birth weight was available in 33 cases and 99 controls, and was higher in the former (median 3.50 kg) than in the latter (median 3.30 kg) (P less than 0.01). Our findings suggest the existence of either a risk factor associated with rapid growth or a protective factor connected with slow growth, effective even before birth.

Adolescent↗
PubMed1978

An HLA map of Europe.

HLA--A and B antigen frequencies from 65 different population samples (61 European and 4 non-European) have been tabulated. Pairwise genetic distances were calculated between some of the populations using HLA--A and B data. The distances obtained with these two series were very strongly correlated. Distances obtained with ABO blood groups (in part of the material) showed weaker but still highly significant correlation with those obtained from combined HLA--A and B data. In general, neighbouring countries had low distances, and of the populations studied, Essen would represent the 'middle' population in Europe. The supposedly inbred population of Sardinia showed the highest distances. The data may be useful for comparison in new HLA studies and can be used for further phylogenic studies.

ABO Blood-Group System↗