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Biomedical subjects

E Andersen

Publications and source records attributed to E Andersen.

At least 109 records · Page 6Linked to original sources
PubMed1989

[The occurrence of denticles in the craniums of Norwegian Samis (Lapps)].

The purpose of the present radiologic study was to establish prevalence and distribution of pulp stones in mandibular premolars and molars in skulls of Norwegian Samis. The results were compared to those of previous investigations of ancient Eskimos, medieval Norsemen from Greenland, Danish Stone Age People and ancient Nubians. Forty-eight dentitions were radiographed and pulp stones recorded according to number and location within the teeth. Twenty-six percent of the Samis exhibited pulp stones. Molars showed a significantly higher prevalence of pulp stones than did premolars. The giant pulp calcifications described previously were limited to first and second molars. Pulp stones were located in pulp chambers only. Symmetric occurrence of pulp stones was common in contralateral teeth. Further epidemiologic studies of pulp stones in ethnic groups are needed.

Dental Pulp Calcification↗
PubMed1989

Acute psychotic disorders treated with 5% zuclopenthixol acetate in 'Viscoleo' ('Cisordinol-Acutard'), a global assessment of the clinical effect: an open multi-centre study.

In an open clinical multi-centre trial carried out in five Danish psychiatric departments, patients suffering from acute psychosis including mania or exacerbation of chronic psychosis were given injections of 5% zuclopenthixol acetate in 'Viscoleo'. The object of the trial was to evaluate the treatment by means of a global assessment of the severity of the psychosis, the therapeutic effect and the side-effects. The results showed that the treatment was rapidly effective in reducing the severity of psychotic symptoms combined with an advantageous unspecific sedation. The side-effect profile was similar to that after other neuroleptics. Special attention should be paid, however, to a possible occurrence of acute dystonia which was observed particularly in young men with acute psychosis.

Acute Disease↗
PubMed1989

Temperatures measured during reaming of the femoral neck and head. A preliminary report.

Thermal injury is a well-known complication during mechanical manipulation of cortical bone. In order to investigate the magnitude of the problem in relation to cancellous bone, the temperature elevation in the head of the femur during reaming for a sliding screw osteosynthesis was measured in ten patients. Temperatures in excess of 50 degrees for a duration of more than one minute were found within approximately 2 mm from the periphery of the reamer. This finding implies that the thread of the screw will be placed in an osteonecrotic zone.

Aged↗
PubMed1989

Gastric banding in the treatment of morbid obesity. Factors influencing immediate and long-term results.

Gastric banding for morbid obesity was performed on 73 patients between April 1983 and December 1986. Early complications occurred in 16% and late complications in 15% of the cases. A second operation was performed on 12 patients, with removal of the band in 11 (15%). Initial weight loss was rapid. Re-examination of 67 patients indicated that this initial loss was followed by a time-related weight gain. Weight reduction occurred as a fairly constant proportion of preoperative weight, irrespective of the degree of obesity. Weight loss to body mass index less than or equal to 30 seems to be a realistic expectation only for moderately overweight patients, not for the hyperobese. Older patients had least weight loss. The data suggest that dietary restrictions will still be needed after gastric banding.

Adult↗
PubMed1988

Garden's classification of femoral neck fractures. An assessment of inter-observer variation.

Radiographs of 100 randomly chosen femoral neck fractures were assessed by eight observers using Garden's classification. The radiographs were classified identically by all eight in only 22 cases. Another 45 cases were classified by some observers as undisplaced fractures (Stages 1 and 2) and by others as displaced fractures (Stages 3 and 4). Between the different observers the number of displaced fractures varied from 63 to 89. These results show that observers had a relatively poor ability to delineate the various stages of Garden's classification.

Femoral Neck Fractures↗
PubMed1988

Within month variability in use of soup kitchens in New York State. p4.

This paper describes the variation in use of soup kitchens throughout the month using data from the New York State Nutritional Surveillance Program. Excluding November, December, and May, when holiday meals created a different pattern of use, number of meals served in soup kitchens generally increased toward the end of the month, averaging 43 per cent higher for Upstate and 14 per cent higher for New York City in the last week as compared to the first week of the month. The overall increase throughout the month and difference in the magnitude of increase between Upstate and New York City corresponds to the timing of income maintenance benefits distribution. Distribution of most public assistance benefits occurs at the beginning of each month in Upstate, whereas it is staggered in New York City throughout the month.

Food Services↗
PubMed1988

Phase I study of 4-demethoxydaunorubicin by oral route in patients with advanced cancer.

In a phase I trial 4-demethoxydaunorubicin (4-dm DNR) was administered as oral capsules once a week to 51 adults with advanced mainly gastrointestinal solid tumors. No fatal toxicity was observed at doses up to 25.0 mg/m2. Dose-limiting granulocytopenia and non-hematologic toxicity developed at dosages greater than or equal to 22.5 mg/m2. No response to the therapy was observed. The plasma concentrations of 4-dm DNR were measured in 4 of the patients.

Administration, Oral↗
PubMed1988

CHOP versus prednisolone + chlorambucil in chronic lymphocytic leukemia (CLL): preliminary results of a randomized multicenter study.

Five hundred and fifty consecutive patients with newly diagnosed B-CLL have been registered and classified in a Danish multicenter study. The study includes a protocol for primary treatment of patients in stage B or C (at diagnosis or after demonstrated progression), below 76 years of age, and without complicating serious disease. Until now 144 such patients have been randomized to either prednisolone (PRD) plus chlorambucil (CLB) 5 days every 4 weeks or monthly intensive CHOP treatment. Twenty-nine percent of the treated patients achieved CR on PRD + CLB versus 63% on CHOP (p less than 0.005). No response was found in 29% versus 18%, respectively (NS). A significant difference in survival between patients achieving CR, PR and NR was also demonstrated, whereas to date no difference in survival could be demonstrated between the two regimens. The toxicity was limited, and only 2 treatment-related deaths occurred in approximately 700 CHOP treatment series.

Adult↗
PubMed1988

The CLL2 study: preliminary results of flow cytometry immunophenotyping in the first 500 patients.

In the period 1984-1987, 500 consecutive, newly diagnosed patients with chronic lymphocytic leukaemia (CLL) have been registered in the still open Danish CLL2-study. As part of patient work-up, the immunological phenotype was established in all patients by immunofluorescence microscopy, and in 458 patients also by flow cytometry, with a panel of polyclonal and monoclonal antibodies. The majority of cases exhibited a CD5-pos, SmIgMD-pos phenotype with faint SmIg-fluorescence, and there is as yet no significant difference in survival between SmIgD-pos and SmIgD-neg cases. Seventy cases were FMC7-pos, a marker associated with a higher B-cell differentiation, and this was significantly correlated with stronger SmIg fluorescence intensity and splenomegaly (Rai stage II). The survival of the FMC7-pos patients was not significantly different from that of the FMC7-neg. Thus, in this preliminary phenotype analysis of the first 500 patients in the CLL2 study, no important prognostic subgroups were detected, although this might be due to the still short observation time (median observation time 532 days).

Denmark↗
PubMed1987

Oral ftorafur versus intravenous 5-fluorouracil. A comparative study in patients with colorectal cancer.

The toxicities of oral Ftorafur (1 g/m2/day 1-21) and intravenous 5-fluorouracil (5-FU) (500 mg/m2/day 1-5) were compared in a prospective randomized study in patients with colorectal cancer. The treatment courses were repeated every 6th week. Leucopenia was more common after 5-FU. Leucocyte nadir in connection with first treatment cycle was on average seen on day 15 in patients receiving 5-FU and on day 28 in patients receiving Ftorafur. Significantly more patients on 5-FU developed stomatitis. There was no difference in the number of patients with diarrhea or nausea/vomiting. Median survival and response rates were not significantly different after the two treatment schedules.

Administration, Oral↗
PubMed1987

Fixation of displaced femoral neck fractures. A comparison between sliding screw plate and four cancellous bone screws.

In a prospective, randomized trial, 104 consecutive patients with displaced femoral neck fractures were allocated either to fixation with a sliding screw plate or 4 ASIF cancellous bone screws. The patients were reexamined at fixed intervals to determine the time of union. The 2-year-cumulated rate of union was 64 per cent in the plate group and 84 per cent in the screw group.

Adult↗
PubMed1986

Periaqueductal gray and cerebral cortex modulate responses of medial thalamic neurons to noxious stimulation.

The response of medial thalamic neurons to noxious peripheral stimulation were studied with intracellular recording methods in the cat. Electrical stimulation of the contralateral forepaw produced an EPSP-IPSP sequence followed by rebound excitation in these medial thalamic neurons. Action potentials appeared with the initial EPSP or with the rebound excitation. The mean latency to onset was 15 ms for the EPSP and 33 ms for IPSP. In contrast, electrical stimulation of the PAG or of the pericruciate cerebral cortex produced large IPSPs in the medial thalamic neurons. When PAG or cortex stimulation were paired with noxious stimulation, both the PAG and cortex responses predominated over the noxious response. This shows that the PAG and the cerebral cortex have the capabilities of influencing the responses of the medial thalamus to noxious stimulation. The medial thalamus is part of the relay system which sends information about noxious stimulation to the cerebral cortex where the noxious information reaches conscious awareness, so influencing the message at the level of the medial thalamus would probably alter the conscious perception of pain. The data suggest the existence of an ascending pain modulation system from the midbrain to the thalamus and also suggests a mechanism of cortical control over pain perception.

Animals↗
PubMed1986

Treatment of lateral instability of the ankle--a new modification of the Evans repair.

A modification of the Evans repair using only half of the peroneus brevis tendon was applied in the treatment of 34 patients with chronic functional lateral instability of the ankle. With a median follow-up of 25 months, 32 patients were examined. Functional stability was achieved in all but one patient. This modification of Evans' repair is recommended, as it is technically easy, gives good functional stability, and has the theoretical advantage of saving an important pronator of the foot.

Adolescent↗
PubMed1986

Plica mediopatellaris--arthroscopic resection under local anesthesia.

A consecutive series of 28 patients (31 knees) with a symptomatic mediopatellar plica without concomitant lesions excised arthroscopically under local anaesthesia in the outpatient department is described. The results were classified as excellent or good in 26/31 cases after a median follow-up period of 15 months. It is concluded that excising a fibrosed mediopatellar plica large enough to cover the medial femoral condyle during flexion is followed by good results; local anaesthesia is sufficient and economical, and arthroscopic excision under local anaesthesia carries a low morbidity.

Adolescent↗