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Biomedical subjects

E Andersen

Publications and source records attributed to E Andersen.

202 records · Page 12Linked to original sources
PubMedDate not supplied

In B-cell chronic lymphocytic leukaemia chromosome 17 abnormalities and not trisomy 12 are the single most important cytogenetic abnormalities for the prognosis: a cytogenetic and immunophenotypic study of 480 unselected newly diagnosed patients.

Of 560 consecutive, newly diagnosed untreated patients with B CLL submitted for chromosome study, G-banded karyotypes could be obtained in 480 cases (86%). Of these, 345 (72%) had normal karyotypes and 135 (28%) had clonal chromosome abnormalities: trisomy 12 (+12) was found in 40 cases, 20 as +12 alone (+12single), 20 as +12 with additional abnormalities (+12complex). Other frequent findings included abnormalities of 14q, chromosome 17, 13q and 6q. The immunophenotype was typical for CLL in 358 patients (CD5+, Slg(weak), mainly FMC7-) and atypical for CLL in 122 patients (25%) (CD5-, or Slg(strong) or FMC7+). Chromosome abnormalities were found significantly more often in patients with atypical (48%) than in patients with typical CLL phenotype (22%) (P < 0.00005). Also +12complex, 14q+, del6q, and abnormalities of chromosome 17 were significantly more frequent in patients with atypical CLL phenotype, whereas +12single was found equally often in patients with typical and atypical CLL phenotype. The cytomorphology of most of the +12 patients was that of classical CLL irrespective of phenotype. In univariate survival analysis the following cytogenetic findings were significantly correlated to a poor prognosis: chromosome 17 abnormalities, 14q+, an abnormal karyotype, +12complex, more than one cytogenetic event, and the relative number of abnormal mitoses. In multivariate survival analysis chromosome 17 abnormalities were the only cytogenetic findings with independent prognostic value irrespective of immunophenotype. We conclude that in patients with typical CLL immunophenotype, chromosome abnormalities are somewhat less frequent at the time of diagnosis than hitherto believed. +12single is compatible with classical CLL, and has no prognostic influence whereas chromosome 17 abnormalities signify a poor prognosis. In patients with an atypical CLL immunophenotype, chromosome abnormalities including +12complex, 14q+, del 6q and chromosome 17 are found in about 50% of the patients, and in particular chromosome 17 abnormalities suggest a poor prognosis.

Aged↗
PubMedDate not supplied

A prospective clinical study evaluating the safety and effectiveness of narrow-diameter threaded implants in the anterior region of the maxilla.

The aim of the present study of single-tooth implants was to compare the success rate and marginal bone resorption of a narrow-diameter self-tapping implant placed in less available bone volume with the standard-diameter self-tapping implant placed in a well-dimensioned alveolar process. A new abutment technique and a different permanent abutment design were also evaluated. Fifty-five patients were included in the study; 27 patients received 28 standard-diameter (3.75-mm) implants, and 28 patients received 32 narrow-diameter (3.25-mm) implants replacing either a central or a lateral incisor in the maxilla. In an attempt to create an ideal emergence profile and to regenerate papillae, individual acrylic resin tooth-shaped temporary abutments were fabricated, based on impressions made immediately following implant placement, and connected to the implant after 6 months. A minimum of 2 months were then allowed before definitive restorative procedures were performed. Impressions were always made at the implant level. Follow-up examinations were performed at 6 months after loading and 1, 2, and 3 years after loading. Two narrow-diameter implants were lost after 6 months, but no other failures were subsequently observed in any of the groups after that. In both groups, marginal bone loss followed the same pattern and was recorded radiographically to be a mean of 0.4 mm from the first to the last examination.

Adolescent↗
PubMedDate not supplied

Morbidity and short term results in a randomised trial of open compared with closed treatment of chronic pilonidal sinus.

OBJECTIVE: To evaluate the morbidity and short term results after open compared with closed treatment of chronic pilonidal sinus. DESIGN: Randomised control trial. SUBJECTS: 120 of 164 patients with chronic pilonidal sinus treated between April 1987 and April 1989. INTERVENTIONS: 60 patients were treated by excision and primary suture, and 60 by excision and open packing. MAIN OUTCOME MEASURES: Incidence of early complications (bleeding that needed treatment, wound breakdown, infection, haematoma, or wound pain), number of postoperative visits required, and length of sick leave taken. RESULTS: Those patients who underwent excision and suture had slightly but not significantly fewer early complications (16/60, 27%, compared with 23/60, 38%). Most of the early complications were the result of infection (8, 13% compared with 18, 30%, respectively). They also required fewer followup visits and less sick leave, and their wounds healed more quickly. At one year the numbers of late complications were 19 (32%) and 14 (23%), respectively. CONCLUSION: Excision and primary closure of chronic pilonidal sinus causes less morbidity and is more cost effective than excision and open packing. We plan a three year follow-up to see if these results are maintained.

Adolescent↗