Search PubMed⌕ Search

Biomedical subjects

E Alessi

Publications and source records attributed to E Alessi.

At least 37 records · Page 2Linked to original sources
PubMed1999

Erythema elevatum diutinum and HIV infection: a report of five cases.

Erythema elevatum diutinum (EED) is emerging as a specific HIV-associated dermatosis, 11 cases having so far been reported in the medical literature and five patients with the disease having been seen by us during the last 4 years. As the disease is poorly known, it is easily confused with Kaposi's sarcoma or bacillary angiomatosis, but the histopathological features are diagnostic. EED is considered to be an immune complex-mediated vasculitis. A streptococcal infection seemed to be the trigger factor in four of our patients. Partial control of the cutaneous lesions was achieved by the use of antibiotics.

AIDS-Related Opportunistic Infections↗
PubMed1999

Congenital cutaneous multifocal kaposiform hemangioendothelioma.

Kaposiform hemangioendothelioma is a rare vascular neoplasm in children often associated with Kasabach-Merritt syndrome. The tumor usually presents in retroperitoneal location and is rarely present at birth. Cutaneous lesions manifest after birth and must be clinically differentiated from infantile hemangiomas and diffuse neonatal hemangiomatosis. Histologically, it bears similarities with Kaposi sarcoma. We present a case of congenital cutaneous multifocal kaposiform hemangioendothelioma (KHE).

Antigens, CD34↗
PubMed1999

Dystrophic calcinosis cutis in subacute lupus.

Dystrophic calcinosis cutis is known to be associated with various connective tissue disorders but to the best of our knowledge has never been reported in subacute cutaneous lupus erythematosus (SCLE), a distinctive cutaneous subset in the spectrum of lupus erythematosus. It occurs without calcium and phosphorus metabolic abnormalities and may be localized or generalized. We report a patient with SCLE who developed calcinosis cutis and had normal serum calcium and phosphorus levels and, interestingly, a normal concentration of blood ionized calcium. This latter, which represents the active form in the total amount of blood calcium, is a parameter only rarely assessed in patients with dystrophic calcinosis cutis. Thus, other pathogenic factors should be investigated to clarify the pathophysiology of the dystrophic type of calcification.

Calcinosis↗
PubMed1999

Unilesional follicular mycosis fungoides.

Follicular mycosis fungoides (FMF) is an unusual clinical and histological variant of MF, characterized by selective involvement of hair follicles by atypical lymphocytes. We describe a female patient who had follicular papules located only on the medial aspect of her right thigh. To the best of our knowledge, this patient represents the first reported case of unilesional FMF.

Diagnosis, Differential↗
PubMed1998

Cutaneous apocrine mixed tumor: derived from the apocrine duct of the folliculo-sebaceous-apocrine unit?

We report a case of cutaneous mixed tumor (CMT) composed of tubular branching structures lined by cells with apocrine characteristics. In addition, an apocrine duct in the outer sheath of an hair follicle was connected to the mixed tumor, a previously unreported finding. Follicular and sebaceous differentiation have been described in CMT, leading some observers to suggest the existence of an apocrine type of CMT and its presumed differentiation toward the folliculo-sebaceous-apocrine unit (FSAU). Our case demonstrated continuity of an apocrine duct in the FSAU and lends support to the previous speculations about the histogenesis of apocrine type of CMT.

Apocrine Glands↗
PubMed1998

Cutaneous apocrine mixed tumor: derived from the apocrine duct of the folliculo-sebaceous-apocrine unit?

We report a case of cutaneous mixed tumor (CMT) composed of tubular branching structures lined by cells with apocrine characteristics. In addition, an apocrine duct in the outer sheath of an hair follicle was connected to the mixed tumor, a previously unreported finding. Follicular and sebaceous differentiation have been described in CMT, leading some observers to suggest the existence of an apocrine type of CMT and its presumed differentiation toward the folliculo-sebaceous-apocrine unit (FSAU). Our case demonstrated continuity of an apocrine duct in the FSAU and lends support to the previous speculations about the histogenesis of apocrine type of CMT.

Apocrine Glands↗
PubMed1998

Disseminated histoplasmosis presenting with cutaneous lesions in a patient with acquired immunodeficiency syndrome.

OBJECTIVE: Presentation of a case of disseminated histoplasmosis, observed in a non-endemic area, in which cutaneous lesions and fever were the dominant clinical signs of the infection. CASE: A 54-year-old homosexual man with acquired immunodeficiency syndrome (AIDS) related Kaposi's sarcoma presented with cutaneous lesions and fever due to disseminated histoplasmosis. The patient was successfully treated with itraconazole 200 mg/day. He died after 8 months from AIDS dementia complex: disseminated histoplasmosis relapse was not observed. CONCLUSION: The case shows that infection with Histoplasma capsulatum must be considered by dermatologists in HIV/AIDS patients, even in non-endemic areas.

AIDS-Related Opportunistic Infections↗
PubMed1997

CD30-positive multilobated peripheral T-cell lymphoma primarily involving the subcutaneous tissue.

A 55-year-old woman presented with an inflammatory panniculitis-like plaque on her right thigh. Biopsy disclosed a subcutaneous infiltrate of multilobated T lymphocytes strongly expressing the CD30 antigen. A complete clinical remission was achieved with local radiation therapy, with no evidence of recurrence in 13 months of follow-up. To our knowledge, our patient is the first reported case of CD30-positive multilobated peripheral T-cell lymphoma primarily involving the subcutaneous tissue.

Female↗
PubMed1997

Simultaneous occurrence of multiple trichoblastomas and steatocystoma multiplex.

We present a 55-year old man who, since age 21, progressively developed multiple papules and nodules on the face and upper trunk. Light microscopic examination of some of the neoplasms showed trichoblastomas, while others had histopathological features of trichoepithelioma and steatocystoma. Simultaneous occurrence of multiple trichoblastomas/trichoepitheliomas and steatocystomas, not reported previously, could represent multiple neoplasms involving differentiation toward different components of the folliculosebaceous unit.

Cysts↗
PubMed1997

Clear cell hidradenoma associated with the folliculo-sebaceous-apocrine unit. Histologic study of five cases.

Hidradenomas are benign adnexal neoplasms of uncertain derivation. Although most investigators traditionally have considered these neoplasms to exhibit eccrine differentiation, with only occasional reports supporting apocrine derivation, subdivision of hidradenomas into two groups was recently suggested: those with eccrine differentiation (or poroid hidradenomas) and those exhibiting apocrine differentiation (or clear cell hidradenomas). We have observed five cases of clear cell hidradenomas manifesting unquestionable apocrine characteristics excised from sites other than the axilla, and displaying continuity with the epidermis through follicles. Because of the common embryologic derivation of apocrine glands, sebaceous glands, and hair follicles, and their histologic integration as the folliculo-sebaceous-apocrine unit, these findings suggest a possible origin of certain apocrine hidradenomas from pluripotential germinative cells present in follicles.

Acrospiroma↗
PubMed1997

Multiple apocrine hidrocystomas of the eyelids.

We report a patient with multiple apocrine hidrocystoma (cystadenoma) which was characterized by bilateral distribution of the lesions on the eyelids. The disease is benign, but it may be a marker of two rare inherited disorders, the Schöpf-Schulz-Passarge syndrome and a peculiar form of focal dermal hypoplasia.

Eyelid Neoplasms↗
PubMed1996

Nodular trichoblastoma with adamantinoid features.

We report a cutaneous tumor characterized by follicular differentiation and adamantinoid features that we consider to be part of the histopathologic spectrum of trichoblastoma. Previously, similar lesions have been reported in the medical literature as cutaneous lymphadenoma or lymphoepithelial tumor of the skin.

Antigens, Neoplasm↗
PubMed1996

Lichen myxoedematosus in a patient with AIDS.

We report a patient with acquired immunodeficiency syndrome (AIDS) who developed a widespread papular eruption due to deposition of mucin in the dermis. Paraproteinaemia was demonstrated. Lichen myxoedematosus type 2 was diagnosed. This is the third case of this rare disorder reported in a human immunodeficiency virus (HIV)-seropositive subject.

Acquired Immunodeficiency Syndrome↗
PubMed1995

Lichen striatus--a chameleon: an histopathological and immunohistological study of forty-one cases.

Lichen striatus (LS) is an uncommon dermatosis that generally affects children. The histopathology of LS often shows a polymorphic epidermal reaction process of variable lichenoid and spongiotic changes having no specific histopathological criteria or simulating other diseases. In the present study, we have evaluated the histopathological features of 41 biopsy specimens and the immunohistochemical aspects of 10 cases of LS. In 50% of the cases, we found histopathological and immunopathological features constantly present and allowing a correct diagnosis. In 9 cases, the histopathology was not specific, and in 10 cases, a clear differentiation from other diseases was not possible. Immunohistochemical study demonstrated a CD3+ T-lymphocytic infiltration in which CD8+ cells surrounded necrotic keratinocytes and intraepidermal vesicles filled with Langerhans cells. These findings seem to corroborate the hypothesis that a somatic mutation of a keratinocytic clone could induce an autoimmune response of the host.

Antigens, CD↗
PubMed1995

Tuberculosis verrucosa cutis which remained undiagnosed for forty-three years.

An unusual case of tuberculosis verrucosa cutis of the left lower limb in a 65-year-old woman is reported. The disease, arising on the plantar aspect of the foot in 1950, was correctly diagnosed by culture of Mycobacterium tuberculosis complex from a skin biopsy only in 1993. A spectacular improvement of the cutaneous lesions was achieved using combined therapy with isoniazide, rifampicin, ethambutol and pyrazinamide.

Aged↗