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Biomedical subjects

E A Shirokov

Publications and source records attributed to E A Shirokov.

14 recordsLinked to original sources
PubMed1999

[The prevention of stroke: the traditions and the outlook].

The article deals with the clinicians' views on the widely used methods of brain circulation disorders prevention. On their own experience and on the literature data the authors make a conclusion, that insult is being caused by a number of etiological and pathogenic factors. They discuss some methods of hemodynamics reserve estimation and formulate new ideas for the disorders' possible development.

Cerebrovascular Circulation↗
PubMed1998

[Prevention of ischemic stroke and conception of hemodynamic reserve].

Central and cerebral hemodynamics was studied using echocardiography and transcranial dopplerography in 200 poststroke patients over 60 in the course of 5-year follow-up. It was established that cardiac hypodynamic syndrome, i.e. continuous or paroxysmal fall of minute blood volume below 3 l, is the most significant contributing factor in the onset of cerebral ischemia. Drugs are recommended for prevention of ischemic stroke. Those lowering cardiac hemodynamic reserve should be excluded in patients at high risk of acute failure of cerebral circulation.

Angioplasty↗
PubMed1998

[Nimotop: clinical spectrum].

This literature review concerns both well known facts on mechanisms of action of calcium channels blockers and less known effects on different systems of the body. In addition to vascular dilatation, the blockers produce neuroprotective action, promote dysaggregation. Detailed information is given on usage of soluble calcium antagonist-nimotop.

Calcium Channel Blockers↗
PubMed1996

[The pathokinesis of vascular brain lesions].

Pathokinesis as the chain reaction included development and self-regulation of pathological processes which manifested themselves by different forms of cerebrovascular pathology was analysed basing on 5-year follow-up of 200 patients with initial forms of cerebrovascular deficiency and examination of patients with discirculatory encephalopathy (in 100 of them stroke had developed during this time) as well as the data on 873 patients with stroke. Pathokinetic significance of risk factors, conditions predisposing to stroke development and stroke direct reasons are characterised as well as therapy of different intensity. The possibilities of the correction of some pathokinetic mechanisms by means of emergent therapy as well as the role of some uncorrectable factors (biological and situational ones) were defined too. The pathokinetic peculiarities of the main forms of insult were defined more precisely in relation to on the degree of individual compensatory abilities.

Acute Disease↗
PubMed1995

[The basic factors affecting outcomes in strokes].

Outcomes in 1102 patients with 3 main types of stroke have been analysed to determine the significance of basic stroke outcome predictors. They are: type of the stroke, location of the focus, gravity of the patient's condition when the first aid is performed, spectrum of hospital facilities, diseases of the patient before and besides the stroke. A decrease of the mortality rate and optimal level of ADL score after stroke can be provided in cases when intensive care units-general hospitals are the first step of treatment.

Activities of Daily Living↗
PubMed1992

[Revising the principles and improving the methods of differential therapy of ischemic stroke].

In accordance with the clinical and coagulographic data on 172 patients with ischemic brain stroke (IBS), the authors developed a method of the use of some medicamentous agents (heparin, platelet inhibitors, fresh-frozen blood plasma, plasminogen activators, proteolytic enzymes), adapted to concrete characteristics of the coagulation status at different stages of brain infarction formation and permitting the rate of lethal outcomes to be reduced. In disseminated intravascular coagulation seen in patients with the gravest patterns of IBS, heparin may be indicated.

Blood Coagulation↗
PubMed1991

[Diagnosis and treatment of coagulopathic syndromes in ischemic stroke].

A study was made of blood coagulation, physiological anticoagulants and fibrinolysis in 120 elderly patients with cerebrovascular diseases, including 50 subjects in the acute period of ischemic brain stroke. To estimate activation of the fibrinolytic system, the levels of plasminogen and free plasmin were measured. Phasic changes in the system of blood coagulation were detected, variants of antithrombin III depression were delineated, and a relationship was established between the activity of enzymes of the fibrinolytic system and the site of an ischemic focus in the brain. Five coagulopathic syndromes of the acute period of brain stroke were distinguished, the principles of their differentiated treatment were based.

Acute Disease↗