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Biomedical subjects

E A Riabinskaia

Publications and source records attributed to E A Riabinskaia.

At least 19 recordsLinked to original sources
PubMed1991

[The habituation of KM-strain rats to the action of an epileptogenic stimulus].

A decrease in the level of epileptic susceptibility to a strong sound which induces the epileptiform seizures has been studied in KM-strain of rats. Reflectory control of seizure activity, i.e. a decrease in their frequency rate has been shown during a prolonged action of the epileptogenic stimulus. The conditions and dynamics of the decreased epileptic susceptibility during systematic presentation of the epileptogenic stimulus have been found to correlate with eight habituation criteria. This effect is identified as habituation to a pathologic action, and its typical features are described. The results characterizing phenomenological similarity of the processes found in experiments and in clinical studies are discussed. The observed blocking of seizures induced by habituation to the sound is treated as shaping of some defensive antiepileptic processes.

Acoustic Stimulation↗
PubMed1985

[Changes in the level of seizure readiness of KM strain rats undergoing systematic stimulation by light and sound].

A possibility of reflex change in the rats seizure activity level of KM line in which an intensive sound causes epileptiform seizures has been studied. Interrupted light stimulation (non-specific for the given form of seizures) does not cause any seizures. It has been found however that the initial presentations of light stimulation favour the increase of seizure activity level in rats. Prolonged systematic stimulation by an intensive sound or by the light + sound complex cause a gradual drop in the seizure activity level. The light cancellation following a prolonged systematic stimulation by light + + sound causes a short-term rise in the seizure activity level.

Acoustic Stimulation↗
PubMedDate not supplied

[The dependence of spatial-motor asymmetry on the nature of the reinforcement].

Spatial-motor asymmetry (SMA) of rats goal-directed running was studied in condition of numerous alternative choices in complex T-maze. In condition of free choices SMA in trained rats depended on reinforcement biological significance, volume and disposition scheme. In condition of non-free choices a change was possible of asymmetry of sequence of goal-directed motor acts adequate to situation, i.e. SMA regulation. Examples of the presence of properties of ego- and allocentric systems in SMA are given. The results of experiments testify to SMA dependence on the motivation of running, to rightfulness of SMA interpretation as behavioural tactics and to non-coming of SMA of goal-directed running to a simple rotation of animals.

Animals↗
PubMedDate not supplied

[A morphofunctional analysis of the participation of the cerebral cortex in the habituation of Krushinskiĭ-Molodkina strain rats to an epileptogenic stimulus].

Systematic action of epileptogenic stimulus (sound) leads to gradual lowering of the level of convulsive readiness (LCR) in rats of KM (Krushinski'i-Molodkina) line to the formation of the habituation, to blocking of convulsive seizures. It is shown that at single action of sound, functional switching-off of the cerebral cortex causes LCR lowering but does not prevent the development of the epileptiform seizure. Alongside with it, in conditions of repeated sound action, functional decortication considerably retards LCR lowering. After cessation of the cortical depression, during which the rats were given systematic sound exposition, sharp LCR lowering takes place. If the habituation has been already formed, then the subsequent switching-off of the cortex does not lead to LCR growth. Ultrastructural characteristics of asymmetric axo-dendritic and axo-spine synapses in the auditory cerebral cortex of KM line rats in the moment of convulsive seizure testifies to their active functioning, while against the background of short-term habituation to epileptogenic stimulus signs of lowering of the efficiency of synaptic transmission are revealed in these synapses. The obtained results allow to suggest that in the rats of KM line the neocortex takes part in antiepileptic defensive reactions, in LCR regulation in connection with formation of the habituation to systematic action of epileptogenic stimulus.

Acoustic Stimulation↗
PubMedDate not supplied

[The volume of reinforcement and the structure of rat behavior in a radial labyrinth].

In rats choice reaction was elaborated in 12 passages radial labyrinth with different volumes of food only in six of twelve passages. Then the conditions were modified: the first group of rats in the beginning of the experiment was placed to another labyrinth sector, and in the second group the food volume was changed in passages. In new situations in animals of both groups the reaction efficiency temporarily decreased, simultaneously the correction of behaviour structure took place. The character of behavioural tactics (tendencies to visit passages with larger food volume at the beginning of the experiment, spatial-motor asymmetry etc.) is described in dynamics of adaptation to new conditions. Factors determining the rats behaviour structure are discussed.

Animals↗
PubMedDate not supplied

[Behavioral tactics of rats receiving unequally distributed reinforcement in a radial maze].

Rats behaviour was studied in 12-arms radial maze with food reinforcement of different volumes presented only in 6 passages. Dynamics of changes is shown in the process of learning both in the preference of the passages with greater volume of reinforcement and in the number of errors, characterizing the working and referent memories. In the trained rats, their behaviour is determined by at least two behavioural tactics: visiting more remote passages and choice in the beginning of the test of more reinforced passages.

Animals↗
PubMedDate not supplied

[Spatial-motor asymmetry in rat behavior].

The experiments were carried out on rats in three different mazes: U-shape, complicated linear and 12-beam radial. Series of tests differed by succession of rats learning in the mazes and the character of reinforcement. Most of the rats manifested a spatial-motor asymmetry (SMA) in all used situations. Under all conditions SMA increased in the process of learning parallel to a decrease of the errors number or the time of the task performing. In the group of rats sequently learning in different mazes, the direction of moving changed with changes in spatial characteristics of the medium. Preliminary training of rats in conditions creating SMA, promoted its acceleration in new conditions. The conclusion is made that the rats have no physiological mechanism which rigidly fixes a single (in all conditions) direction of runs. SMA is considered as a behavioural tactics which is corrected in the process of training and which provides for an adequate behaviour.

Animals↗
PubMedDate not supplied

[Behavioral tactics among rats in a radial maze].

The experiments were carried out on rats of Wistar (W) and Krushinsky-Molodkina (KM) lines, differing in the level of task performance in conditions of multiple choice of food sources in a 12ray radial symmetrical maze. It is shown that in the radial maze, the rats of both lines use a number of behavioural tactics. To determine the influence of changes of environmental spatial characteristics while preserving the main experimental strategy--never revisit the places of reinforcement,--on the peculiarities of tactics manifestations maze modifications were elaborated. Besides the environmental procedure was changed. Under all conditions the rats of W line solved the task. According to the situation, they either preserved former tactics or developed some new ones. The rats of KM line could not solve the task in changed conditions. In most sessions, appearance or absence of given tactics was not adequate to new conditions. The presence of the necessary tactics not always facilitated the task solving. Thus, for the realization of adequate reactions, the presence of necessary tactics is not sufficient: their "tuning" is needed depending on situation. The possibility is supposed of genetic determination of rats ability to some tactics. However, it is emphasized, that tactics are not strongly fixed, as their realization depends on environmental conditions.

Animals↗
PubMedDate not supplied

[Asymmetry of movement direction as a tactic in the feeding behavior of rats].

The sign and degree of spatial-motor asymmetry in rats were studied in conditions both of spontaneous or signalled choice in an U-maze and spontaneous multiple choice in a radial labyrinth. It was shown that during investigation of a new environment, motor asymmetry in rats was feebly expressed in all conditions of experiments, irrespective of the labyrinth scheme and experimental procedures. In the process of training, adequate behaviour was formed and in some conditions a distinctly expressed spatial asymmetry appeared, while in other cases it was absent. Apparently, while investigating an "unknown" situation (where rats can move rightwards and leftwards), the strategy of "displacement" is characteristic of them. Later the rate of asymmetry manifestation depends on concrete spatial and temporal characteristics of already "familiar" surroundings.

Animals↗
PubMedDate not supplied

[Training of rats of the Wistar and Krushinskii-Molodkinaia lines in a radial maze].

The experiments were conducted on rats of Wistar (W) and Krushinsky--Molodkina (KM) (with audiogenic epilepsy) lines in 12-rays radial-symmetrical labyrinth. The trained rats of W line made less erroneous (repeated) visits to the labyrinth corridors than the rats of KM line. The corridors repeatedly visited by the rats of W line were more frequently situated near the unvisited corridors. No definite sequence of corridors' visiting by the rats of both lines was observed; still there was a tendency to choose corridors the most remoted from each other. This tendency intensified in the process of training. This is considered as one of tactics of rats' behaviour, providing for adequate reactions in definite surrounding conditions.

Animals↗